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03.08.2020 | Brief Report

Hepatitis D virus seroprevalence in Egyptian HBsAg-positive children: a single-center study

verfasst von: Hanan M. Fouad, Amal Ahmed, Ehab Mahfouz Reyad, Sanaa Mohammed ElSadek, Rania Abdelmonem Khattab, Dalia Ali El Damasy

Erschienen in: Archives of Virology | Ausgabe 10/2020

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Abstract

In this study, we investigated the seroprevalence of anti-hepatitis D virus (HDV) antibodies in hepatitis B surface antigen (HBsAg)-positive children after 25 years of obligatory vaccination of infants against hepatitis B virus. This cross-sectional study included 120 treatment-naïve HBsAg-positive children, with a male-to-female ratio of 1.8:1 and a mean age of 7.8 ± 3.8 years (range, 1-17 years). Mothers were positive for HBsAg in 96.6% of the cases. HBeAg-positive chronic infection was observed in 60% of the cases, HBeAg-positive chronic hepatitis in 12.5%, and HBeAg-negative chronic infection in 26.7%. Anti-HDV antibodies were not detected in any of the cases. Thus, there is a lack of anti-HDV antibodies in HBsAg-positive children, despite the current burden in adults.
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Metadaten
Titel
Hepatitis D virus seroprevalence in Egyptian HBsAg-positive children: a single-center study
verfasst von
Hanan M. Fouad
Amal Ahmed
Ehab Mahfouz Reyad
Sanaa Mohammed ElSadek
Rania Abdelmonem Khattab
Dalia Ali El Damasy
Publikationsdatum
03.08.2020
Verlag
Springer Vienna
Erschienen in
Archives of Virology / Ausgabe 10/2020
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-020-04757-6

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