Hepatitis E virus subtype 3f infections: rare but increasingly identified in Japan
- 01.12.2025
- Brief Report
- Verfasst von
- Tatsunori Nakano
- Hiroshi Okano
- Satoko Uraki
- Takahiro Ono
- Atsuya Shimizu
- Masaharu Takahashi
- Shigeo Nagashima
- Kazumoto Murata
- Hiroaki Okamoto
- Erschienen in
- Archives of Virology | Ausgabe 12/2025
Abstract
Forty-two human-derived hepatitis E virus subtype 3f (HEV-3f) strains, identified in Japan between 1998 and 2024, were analyzed based on their genome sequences. Fourteen strains in the Kanto region and two in Mie Prefecture exhibited close genetic relatedness to each other but were distinct from European HEV-3f strains, suggesting possible endemic circulation in Japan. Conversely, seven strains from individuals without a history of travel shared identical nucleotide sequences with European HEV-3f, suggesting that these infections were potentially linked to imported pork. Comprehensive molecular and epidemiological studies are needed to clarify the relative contributions of local zoonotic transmission from domestic or wild animals versus foodborne introduction via imported pork products.
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- Titel
- Hepatitis E virus subtype 3f infections: rare but increasingly identified in Japan
- Verfasst von
-
Tatsunori Nakano
Hiroshi Okano
Satoko Uraki
Takahiro Ono
Atsuya Shimizu
Masaharu Takahashi
Shigeo Nagashima
Kazumoto Murata
Hiroaki Okamoto
- Publikationsdatum
- 01.12.2025
- Verlag
- Springer Vienna
- Erschienen in
-
Archives of Virology / Ausgabe 12/2025
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798 - DOI
- https://doi.org/10.1007/s00705-025-06467-3
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