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28.07.2022 | Short Communication

Hepatocellular carcinoma and solid pseudopapillary neoplasm of the pancreas complicating familial adenomatous polyposis: two cases and review of the literature

verfasst von: Jessica El Halabi, Lisa LaGuardia, R. Matthew Walsh, Choon Hyuck David Kwon, K. V. Narayanan Menon, David Liska, Carol A. Burke

Erschienen in: Familial Cancer | Ausgabe 1/2023

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Abstract

Familial adenomatous polyposis (FAP) is characterized by colorectal polyposis and extracolonic tumors. Adenocarcinoma of the pancreas and hepatocellular carcinoma are rare in FAP. In this case series, we describe a mother and daughter with FAP who developed a hepatocellular carcinoma and solid pseudopapillary neoplasm of the pancreas, respectively.
Literatur
1.
Zurück zum Zitat Half E, Bercovich D, Rozen P (2009) Familial adenomatous polyposis. Orphanet J Rare Dis 4(1):1–23CrossRef Half E, Bercovich D, Rozen P (2009) Familial adenomatous polyposis. Orphanet J Rare Dis 4(1):1–23CrossRef
2.
Zurück zum Zitat Anaya DA, Chang GJ, Rodriguez-Bigas MA (2008) Extracolonic manifestations of hereditary colorectal cancer syndromes. Clin Colon Rectal Surg 21(04):263–272CrossRef Anaya DA, Chang GJ, Rodriguez-Bigas MA (2008) Extracolonic manifestations of hereditary colorectal cancer syndromes. Clin Colon Rectal Surg 21(04):263–272CrossRef
3.
Zurück zum Zitat McGlynn KA, Petrick JL, El-Serag HB (2021) Epidemiology of hepatocellular carcinoma. Hepatology 73:4–13CrossRef McGlynn KA, Petrick JL, El-Serag HB (2021) Epidemiology of hepatocellular carcinoma. Hepatology 73:4–13CrossRef
4.
Zurück zum Zitat Herbst DA, Reddy KR (2012) Risk factors for hepatocellular carcinoma. Clin Liver Dis 1(6):180–182CrossRef Herbst DA, Reddy KR (2012) Risk factors for hepatocellular carcinoma. Clin Liver Dis 1(6):180–182CrossRef
5.
Zurück zum Zitat Syngal S, Brand RE, Church JM, Giardiello FM, Hampel HL, Burt RW (2015) ACG clinical guideline: genetic testing and management of hereditary gastrointestinal cancer syndromes. Am J Gastroenterol 110(2):223CrossRef Syngal S, Brand RE, Church JM, Giardiello FM, Hampel HL, Burt RW (2015) ACG clinical guideline: genetic testing and management of hereditary gastrointestinal cancer syndromes. Am J Gastroenterol 110(2):223CrossRef
6.
Zurück zum Zitat Veale A (1965) Intestinal polyposis. Eugenics Lab. Memoirs, Series 40. Cambridge University Press, London Veale A (1965) Intestinal polyposis. Eugenics Lab. Memoirs, Series 40. Cambridge University Press, London
7.
Zurück zum Zitat Zeze F, Ohsato K, Mitani H, Ohkuma R, Koide O (1983) Hepatocellular carcinoma associated with familial polyposis of the colon. Dis Colon Rectum 26(7):465–468CrossRef Zeze F, Ohsato K, Mitani H, Ohkuma R, Koide O (1983) Hepatocellular carcinoma associated with familial polyposis of the colon. Dis Colon Rectum 26(7):465–468CrossRef
8.
Zurück zum Zitat Laferla G, Kaye S, Crean G (1988) Hepatocellular and gastric carcinoma associated with familial polyposis coli. J Surg Oncol 38(1):19–21CrossRef Laferla G, Kaye S, Crean G (1988) Hepatocellular and gastric carcinoma associated with familial polyposis coli. J Surg Oncol 38(1):19–21CrossRef
9.
Zurück zum Zitat Van Steenbergen W, Fevery J, De Groote J, Baert A, Desmet V, Van Eyken P (1989) Hepatocellular carcinoma in a case of familial polyposis coli. Am J Gastroenterol 84(9):1120–1121 Van Steenbergen W, Fevery J, De Groote J, Baert A, Desmet V, Van Eyken P (1989) Hepatocellular carcinoma in a case of familial polyposis coli. Am J Gastroenterol 84(9):1120–1121
10.
Zurück zum Zitat Spigelman A, Farmer K, James M, Richman P, Phillips R (1991) Tumours of the liver, bile ducts, pancreas and duodenum in a single patient with familial adenomatous polyposis. J Br Surg 78(8):979–980CrossRef Spigelman A, Farmer K, James M, Richman P, Phillips R (1991) Tumours of the liver, bile ducts, pancreas and duodenum in a single patient with familial adenomatous polyposis. J Br Surg 78(8):979–980CrossRef
11.
Zurück zum Zitat Gruner BA, DeNapoli TS, Andrews W, Tomlinson G, Bowman L, Weitman SD (1998) Hepatocellular carcinoma in children associated with gardner syndrome or familial adenomatous polyposis. J Pediatr Hematol Oncol 20(3):274–278CrossRef Gruner BA, DeNapoli TS, Andrews W, Tomlinson G, Bowman L, Weitman SD (1998) Hepatocellular carcinoma in children associated with gardner syndrome or familial adenomatous polyposis. J Pediatr Hematol Oncol 20(3):274–278CrossRef
12.
Zurück zum Zitat Paulson S, Patel C, Patel H (2016) From the gut to the liver: another organ to watch in FAP patients. Case reports in pathology 2016 Paulson S, Patel C, Patel H (2016) From the gut to the liver: another organ to watch in FAP patients. Case reports in pathology 2016
13.
Zurück zum Zitat Law JK, Ahmed A, Singh VK et al (2014) A systematic review of solid-pseudopapillary neoplasms: are these rare lesions? Pancreas 43(3):331CrossRef Law JK, Ahmed A, Singh VK et al (2014) A systematic review of solid-pseudopapillary neoplasms: are these rare lesions? Pancreas 43(3):331CrossRef
14.
Zurück zum Zitat Papavramidis T, Papavramidis S (2005) Solid pseudopapillary tumors of the pancreas: review of 718 patients reported in English literature. J Am Coll Surg 200(6):965–972CrossRef Papavramidis T, Papavramidis S (2005) Solid pseudopapillary tumors of the pancreas: review of 718 patients reported in English literature. J Am Coll Surg 200(6):965–972CrossRef
15.
Zurück zum Zitat Song H, Dong M, Zhou J, Sheng W, Zhong B, Gao W (2017) Solid pseudopapillary neoplasm of the pancreas: clinicopathologic feature, risk factors of malignancy, and survival analysis of 53 cases from a single center. BioMed Res Int 2017:1–7CrossRef Song H, Dong M, Zhou J, Sheng W, Zhong B, Gao W (2017) Solid pseudopapillary neoplasm of the pancreas: clinicopathologic feature, risk factors of malignancy, and survival analysis of 53 cases from a single center. BioMed Res Int 2017:1–7CrossRef
16.
Zurück zum Zitat Mao C, Guvendi M, Domenico DR, Kim K, Thomford NR, Howard JM (1995) Papillary cystic and solid tumors of the pancreas: a pancreatic embryonic tumor? Studies of three cases and cumulative review of the world’s literature. Surgery 118(5):821–828CrossRef Mao C, Guvendi M, Domenico DR, Kim K, Thomford NR, Howard JM (1995) Papillary cystic and solid tumors of the pancreas: a pancreatic embryonic tumor? Studies of three cases and cumulative review of the world’s literature. Surgery 118(5):821–828CrossRef
17.
Zurück zum Zitat Groen EJ, Roos A, Muntinghe FL et al (2008) Extra-intestinal manifestations of familial adenomatous polyposis. Ann Surg Oncol 15(9):2439–2450CrossRef Groen EJ, Roos A, Muntinghe FL et al (2008) Extra-intestinal manifestations of familial adenomatous polyposis. Ann Surg Oncol 15(9):2439–2450CrossRef
18.
Zurück zum Zitat Ruo L, Coit DG, Brennan MF, Guillem JG (2002) Long-term follow-up of patients with familial adenomatous polyposis undergoing pancreaticoduodenal surgery. J Gastrointest Surg 6(5):671–675CrossRef Ruo L, Coit DG, Brennan MF, Guillem JG (2002) Long-term follow-up of patients with familial adenomatous polyposis undergoing pancreaticoduodenal surgery. J Gastrointest Surg 6(5):671–675CrossRef
19.
Zurück zum Zitat Farahmand F, Shoaran M, Fariborzi M, Ashjaei B, Monajemzadeh M, Mehdizadeh M (2012) Pancreatic pseudopapillary tumor in association with colonic polyposis. J Med Med Sci 3:447–451 Farahmand F, Shoaran M, Fariborzi M, Ashjaei B, Monajemzadeh M, Mehdizadeh M (2012) Pancreatic pseudopapillary tumor in association with colonic polyposis. J Med Med Sci 3:447–451
20.
Zurück zum Zitat Inoue T, Nishi Y, Okumura F et al (2015) Solid pseudopapillary neoplasm of the pancreas associated with familial adenomatous polyposis. Intern Med 54(11):1349–1355CrossRef Inoue T, Nishi Y, Okumura F et al (2015) Solid pseudopapillary neoplasm of the pancreas associated with familial adenomatous polyposis. Intern Med 54(11):1349–1355CrossRef
21.
Zurück zum Zitat Naoi D, Koinuma K, Sasanuma H et al (2021) Solid-pseudopapillary neoplasm of the pancreas in a patient with familial adenomatous polyposis: a case report. Surg Case Rep 7(1):1–6CrossRef Naoi D, Koinuma K, Sasanuma H et al (2021) Solid-pseudopapillary neoplasm of the pancreas in a patient with familial adenomatous polyposis: a case report. Surg Case Rep 7(1):1–6CrossRef
22.
Zurück zum Zitat Miller J (2001) Protein family review the wnts. Gene 1:15 Miller J (2001) Protein family review the wnts. Gene 1:15
23.
Zurück zum Zitat Terris B, Pineau P, Bregeaud L et al (1999) Close correlation between β-catenin gene alterations and nuclear accumulation of the protein in human hepatocellular carcinomas. Oncogene 18(47):6583–6588CrossRef Terris B, Pineau P, Bregeaud L et al (1999) Close correlation between β-catenin gene alterations and nuclear accumulation of the protein in human hepatocellular carcinomas. Oncogene 18(47):6583–6588CrossRef
24.
Zurück zum Zitat de La Coste A, Romagnolo B, Billuart P et al (1998) Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas. Proc Natl Acad Sci 95(15):8847–8851CrossRef de La Coste A, Romagnolo B, Billuart P et al (1998) Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas. Proc Natl Acad Sci 95(15):8847–8851CrossRef
Metadaten
Titel
Hepatocellular carcinoma and solid pseudopapillary neoplasm of the pancreas complicating familial adenomatous polyposis: two cases and review of the literature
verfasst von
Jessica El Halabi
Lisa LaGuardia
R. Matthew Walsh
Choon Hyuck David Kwon
K. V. Narayanan Menon
David Liska
Carol A. Burke
Publikationsdatum
28.07.2022
Verlag
Springer Netherlands
Erschienen in
Familial Cancer / Ausgabe 1/2023
Print ISSN: 1389-9600
Elektronische ISSN: 1573-7292
DOI
https://doi.org/10.1007/s10689-022-00305-0

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