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Erschienen in: Virchows Archiv 1/2018

26.05.2018 | Review and Perspectives

Hepatocellular nodules in vascular liver diseases

verfasst von: Christine Sempoux, Charles Balabaud, Valérie Paradis, Paulette Bioulac-Sage

Erschienen in: Virchows Archiv | Ausgabe 1/2018

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Abstract

Hepatocellular nodules have been recognized in vascular liver diseases for a long time and mostly described and studied in the imaging literature. Some confusions in their identification and overlap in their definitions exist, especially in this specific clinical context. Pathology descriptions report the development of nodular regenerative hyperplasia, large regenerative nodule, and focal nodular hyperplasia, as adaptive responses of the liver parenchyma to the modified blood flow. True neoplastic hepatocellular nodules such as hepatocellular adenoma and hepatocellular carcinoma can also appear, mainly in Budd-Chiari syndrome, and have to be correctly diagnosed. This is more difficult for the radiologist in these diseased livers, leading more frequently to perform liver biopsies. We describe the histology of each type of well-differentiated hepatocellular nodules and provide some clues for their differential diagnosis. A review of the literature gives an historical perspective of the problem and enlightens the frequency and the subtypes of hepatocellular nodules found in the most common vascular liver diseases.
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Metadaten
Titel
Hepatocellular nodules in vascular liver diseases
verfasst von
Christine Sempoux
Charles Balabaud
Valérie Paradis
Paulette Bioulac-Sage
Publikationsdatum
26.05.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Virchows Archiv / Ausgabe 1/2018
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-018-2373-6

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