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Current Hepatology Reports
Erschienen in: Current Hepatology Reports 4/2017

24.10.2017 | Drug-Induced Liver Injury (F Bessone and R Andrade, Section Editors)

Hepatotoxicity in Patients with Metabolic Syndrome: Causes and Consequences

verfasst von: Jose Ignacio Vargas, Juan Pablo Arab, Fernando Bessone, Maria Isabel Lucena, Raul J. Andrade, Marco Arrese

Erschienen in: Current Hepatology Reports | Ausgabe 4/2017

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Abstract

Purpose of Review

The purpose of this review was to analyze the current evidence regarding the incidence, mechanisms, and outcomes of drug-induced liver injury (DILI) and hepatotoxicity in patients with metabolic syndrome and nonalcoholic fatty liver disease.

Recent Findings

DILI is a complex clinical entity. Although uncommon, its incidence and diagnosis have been rising in recent years as basic research and clinical databases provide information about its etiology, clinical course, and prognosis. The prevalence of metabolic syndrome and non-alcoholic fatty liver disease is on the rise in western countries. Recently, features of the metabolic syndrome have been identified as factors affecting the phenotype and evolution of DILI, both in pre-clinical and clinical research.

Summary

In the present review, we summarize current evidence regarding the influence of features of metabolic syndrome in the presentation, clinical course, and prognosis of DILI.
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Metadaten
Titel
Hepatotoxicity in Patients with Metabolic Syndrome: Causes and Consequences
verfasst von
Jose Ignacio Vargas
Juan Pablo Arab
Fernando Bessone
Maria Isabel Lucena
Raul J. Andrade
Marco Arrese
Publikationsdatum
24.10.2017
Verlag
Springer US
Erschienen in
Current Hepatology Reports / Ausgabe 4/2017
Elektronische ISSN: 2195-9595
DOI
https://doi.org/10.1007/s11901-017-0380-8

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