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Erschienen in: Comparative Clinical Pathology 2/2017

04.03.2016 | Review Article

Herbal remedies against gastric cancer in experimental rats

verfasst von: Aidin Shojaee Tabrizi, Marjan Mohammadi

Erschienen in: Comparative Clinical Pathology | Ausgabe 2/2017

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Abstract

Gastric cancer is the fourth most prevalent cancer worldwide, which claims more than 700,000 lives every year. However, the current chemical and surgical management of this mortal cancer remains far from successful. A recent safe approach to preventing or treating tumorigenesis has been the re-introduction of traditional herbal medicine, taking advantage of efficient, yet natural healthy products. In this review, we have focused on a number of such popular agents, mostly introduced by the Traditional Chinese medicine (TCM), which have exhibited highly significant preventive/therapeutic effects against various gastric pathologies, ranging from gastritis to premalignant lesions and confirmed malignancies, in experimental rats. The underlying mechanisms of action seem to concentrate on shifting the balance between in vivo oxidant and anti-oxidant activities. In addition, the existing reports on the potential toxicity of these compounds, as well as their interactions with chemical drugs, have been presented. However, far more details are required to recommend herbal medicine as an effective and reliable plan of action in gastric cancer management.
Literatur
Zurück zum Zitat Abdullaev FI (1994) Inhibitory effect of crocetin on intracellular nucleic acid and protein synthesis in malignant cells. Toxicol Lett 70:243–251CrossRefPubMed Abdullaev FI (1994) Inhibitory effect of crocetin on intracellular nucleic acid and protein synthesis in malignant cells. Toxicol Lett 70:243–251CrossRefPubMed
Zurück zum Zitat Alavizadeh SH, Hosseinzadeh H (2014) Bioactivity assessment and toxicity of crocin: a comprehensive review. Food Chem Toxicol 64:65–80CrossRefPubMed Alavizadeh SH, Hosseinzadeh H (2014) Bioactivity assessment and toxicity of crocin: a comprehensive review. Food Chem Toxicol 64:65–80CrossRefPubMed
Zurück zum Zitat Bagchi D, Swaroop A, Preuss HG, Bagchi M (2014) Free radical scavenging, antioxidant and cancer chemoprevention by grape seed proanthocyanidin: an overview. Mut Res 768:69–73CrossRef Bagchi D, Swaroop A, Preuss HG, Bagchi M (2014) Free radical scavenging, antioxidant and cancer chemoprevention by grape seed proanthocyanidin: an overview. Mut Res 768:69–73CrossRef
Zurück zum Zitat Bathaie SZ, Hoshyar R, Miri H, Sadeghizadeh M (2013) Anticancer effects of crocetin in both human adenocarcinoma gastric cancer cells and rat model of gastric cancer. Biochem Cell Biol 91:397–403CrossRefPubMed Bathaie SZ, Hoshyar R, Miri H, Sadeghizadeh M (2013) Anticancer effects of crocetin in both human adenocarcinoma gastric cancer cells and rat model of gastric cancer. Biochem Cell Biol 91:397–403CrossRefPubMed
Zurück zum Zitat Chen H-J, Shih C-K, Hsu H-Y, Chiang W (2010) Mast cell-dependent allergic responses are inhibited by ethanolic extract of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) testa. J Agric Food Chem 58:2596–2601CrossRefPubMed Chen H-J, Shih C-K, Hsu H-Y, Chiang W (2010) Mast cell-dependent allergic responses are inhibited by ethanolic extract of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) testa. J Agric Food Chem 58:2596–2601CrossRefPubMed
Zurück zum Zitat Chen H-H, Chen Y-T, Huang Y-W, Tsai H-J, Kuo C-C (2012) 4-Ketopinoresinol, a novel naturally occurring ARE activator, induces the Nrf2/HO-1 axis and protects against oxidative stress-induced cell injury via activation of PI3K/AKT signaling. Free Radic Biol Med 52:1054–1066CrossRefPubMed Chen H-H, Chen Y-T, Huang Y-W, Tsai H-J, Kuo C-C (2012) 4-Ketopinoresinol, a novel naturally occurring ARE activator, induces the Nrf2/HO-1 axis and protects against oxidative stress-induced cell injury via activation of PI3K/AKT signaling. Free Radic Biol Med 52:1054–1066CrossRefPubMed
Zurück zum Zitat Chung C-P et al (2011) Gastroprotective activities of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on the growth of the stomach cancer AGS cell line and indomethacin-induced gastric ulcers. J Agric Food Chem 59:6025–6033CrossRefPubMed Chung C-P et al (2011) Gastroprotective activities of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on the growth of the stomach cancer AGS cell line and indomethacin-induced gastric ulcers. J Agric Food Chem 59:6025–6033CrossRefPubMed
Zurück zum Zitat Crew KD, Neugut AI (2006) Epidemiology of gastric cancer. World J Gastroenterol WJG 12:354–362CrossRefPubMed Crew KD, Neugut AI (2006) Epidemiology of gastric cancer. World J Gastroenterol WJG 12:354–362CrossRefPubMed
Zurück zum Zitat Dhar A et al (2009) Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model. Mol Cancer Ther 8:315–323CrossRefPubMed Dhar A et al (2009) Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model. Mol Cancer Ther 8:315–323CrossRefPubMed
Zurück zum Zitat Draudin-Krylenko V, Bukin I, Levchuk A, Davéĭ F (1991) Potential cancer-protective effect of beta-carotene in experimental stomach carcinogenesis. Vopr Med Khim 38:36–39 Draudin-Krylenko V, Bukin I, Levchuk A, Davéĭ F (1991) Potential cancer-protective effect of beta-carotene in experimental stomach carcinogenesis. Vopr Med Khim 38:36–39
Zurück zum Zitat Dreosti IE, Wargovich MJ, Yang C (1997) Inhibition of carcinogenesis by tea: the evidence from experimental studies. Crit Rev Food Sci Nutr 37:761–770CrossRefPubMed Dreosti IE, Wargovich MJ, Yang C (1997) Inhibition of carcinogenesis by tea: the evidence from experimental studies. Crit Rev Food Sci Nutr 37:761–770CrossRefPubMed
Zurück zum Zitat Ekambaram G, Rajendran P, Magesh V, Sakthisekaran D (2008) Naringenin reduces tumor size and weight lost in N-methyl-N′-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats. Nutr Res 28:106–112CrossRefPubMed Ekambaram G, Rajendran P, Magesh V, Sakthisekaran D (2008) Naringenin reduces tumor size and weight lost in N-methyl-N′-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats. Nutr Res 28:106–112CrossRefPubMed
Zurück zum Zitat Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127:2893–2917CrossRefPubMed Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127:2893–2917CrossRefPubMed
Zurück zum Zitat Giridharan VV, Thandavarayan RA, Mani V, Ashok Dundapa T, Watanabe K, Konishi T (2011) Ocimum sanctum Linn. leaf extracts inhibit acetylcholinesterase and improve cognition in rats with experimentally induced dementia. J Med Food 14:912–919CrossRefPubMed Giridharan VV, Thandavarayan RA, Mani V, Ashok Dundapa T, Watanabe K, Konishi T (2011) Ocimum sanctum Linn. leaf extracts inhibit acetylcholinesterase and improve cognition in rats with experimentally induced dementia. J Med Food 14:912–919CrossRefPubMed
Zurück zum Zitat Hannum SM (2004) Potential impact of strawberries on human health: a review of the science. Crit Rev Food Sci Nutr 44:1–17CrossRefPubMed Hannum SM (2004) Potential impact of strawberries on human health: a review of the science. Crit Rev Food Sci Nutr 44:1–17CrossRefPubMed
Zurück zum Zitat Hu P, Wargovich M (1989) Effect of diallyl sulfide on MNNG-induced nuclear aberrations and ornithine decarboxylase activity in the glandular stomach mucosa of the Wistar rat. Cancer Lett 47:153–158CrossRefPubMed Hu P, Wargovich M (1989) Effect of diallyl sulfide on MNNG-induced nuclear aberrations and ornithine decarboxylase activity in the glandular stomach mucosa of the Wistar rat. Cancer Lett 47:153–158CrossRefPubMed
Zurück zum Zitat Huang M-T et al (1992) Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin. Carcinogenesis 13:947–954CrossRefPubMed Huang M-T et al (1992) Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin. Carcinogenesis 13:947–954CrossRefPubMed
Zurück zum Zitat Huang D-W, Chung C-P, Kuo Y-H, Lin Y-L, Chiang W (2009a) Identification of compounds in adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) seed hull extracts that inhibit lipopolysaccharide-induced inflammation in RAW 264.7 macrophages. J Agric Food Chem 57:10651–10657CrossRefPubMed Huang D-W, Chung C-P, Kuo Y-H, Lin Y-L, Chiang W (2009a) Identification of compounds in adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) seed hull extracts that inhibit lipopolysaccharide-induced inflammation in RAW 264.7 macrophages. J Agric Food Chem 57:10651–10657CrossRefPubMed
Zurück zum Zitat Huang D-W, Kuo Y-H, Lin F-Y, Lin Y-L, Chiang W (2009b) Effect of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) Testa and its phenolic components on Cu2+-treated low-density lipoprotein (LDL) oxidation and lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 macrophages. J Agric Food Chem 57:2259–2266CrossRefPubMed Huang D-W, Kuo Y-H, Lin F-Y, Lin Y-L, Chiang W (2009b) Effect of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) Testa and its phenolic components on Cu2+-treated low-density lipoprotein (LDL) oxidation and lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 macrophages. J Agric Food Chem 57:2259–2266CrossRefPubMed
Zurück zum Zitat Huang W-Y, H-c Z, W-x L, C-y L (2012) Survey of antioxidant capacity and phenolic composition of blueberry, blackberry, and strawberry in Nanjing. J Zhejiang Univ Sci B 13:94–102CrossRefPubMedPubMedCentral Huang W-Y, H-c Z, W-x L, C-y L (2012) Survey of antioxidant capacity and phenolic composition of blueberry, blackberry, and strawberry in Nanjing. J Zhejiang Univ Sci B 13:94–102CrossRefPubMedPubMedCentral
Zurück zum Zitat Huang H-C, Hsieh W-Y, Niu Y-L, Chang T-M (2014) Inhibitory effects of Adlay extract on melanin production and cellular oxygen stress in B16F10 melanoma cells. Int J Mol Sci 15:16665–16679CrossRefPubMedPubMedCentral Huang H-C, Hsieh W-Y, Niu Y-L, Chang T-M (2014) Inhibitory effects of Adlay extract on melanin production and cellular oxygen stress in B16F10 melanoma cells. Int J Mol Sci 15:16665–16679CrossRefPubMedPubMedCentral
Zurück zum Zitat Hyun TK, Kim J-S (2009) The pharmacology and clinical properties of Kalopanax pictus. J Med Plants Res 3:613–620 Hyun TK, Kim J-S (2009) The pharmacology and clinical properties of Kalopanax pictus. J Med Plants Res 3:613–620
Zurück zum Zitat Iwasaki Y, Matsui T, Arakawa Y (2004) The protective and hormonal effects of proanthocyanidin against gastric mucosal injury in Wistar rats. J Gastroenterol 39:831–837CrossRefPubMed Iwasaki Y, Matsui T, Arakawa Y (2004) The protective and hormonal effects of proanthocyanidin against gastric mucosal injury in Wistar rats. J Gastroenterol 39:831–837CrossRefPubMed
Zurück zum Zitat Jiang XY, Qian LP, Zheng XJ, Xia YY, JIANG YB, Sun DY (2009) Interventional effect of Ginkgo biloba extract on the progression of gastric precancerous lesions in rats. J Dig Dis 10:293–299CrossRefPubMed Jiang XY, Qian LP, Zheng XJ, Xia YY, JIANG YB, Sun DY (2009) Interventional effect of Ginkgo biloba extract on the progression of gastric precancerous lesions in rats. J Dig Dis 10:293–299CrossRefPubMed
Zurück zum Zitat Jones RC, Sugie S, Braley J, Weisburger JH (1989) Dietary beta-carotene in rat models of gastrointestinal cancer. J Nutr 119:508–514PubMed Jones RC, Sugie S, Braley J, Weisburger JH (1989) Dietary beta-carotene in rat models of gastrointestinal cancer. J Nutr 119:508–514PubMed
Zurück zum Zitat Kanwar J, Mujtaba Taskeen IM, Huo C, Chan TH, Dou QP (2012) Recent advances on tea polyphenols. Front Biosci (Elite ed) 4:111–131CrossRef Kanwar J, Mujtaba Taskeen IM, Huo C, Chan TH, Dou QP (2012) Recent advances on tea polyphenols. Front Biosci (Elite ed) 4:111–131CrossRef
Zurück zum Zitat Katiyar S, Mukhtar H (1996) Tea in chemoprevention of cancer. Int J Oncol 8:221–238PubMed Katiyar S, Mukhtar H (1996) Tea in chemoprevention of cancer. Int J Oncol 8:221–238PubMed
Zurück zum Zitat Kato I, Tominaga S, Matsuura A, Yoshii Y, Shirai M, Kobayashi S (1990) A comparative case control study of colorectal cancer and adenoma. Cancer Sci 81:1101–1108 Kato I, Tominaga S, Matsuura A, Yoshii Y, Shirai M, Kobayashi S (1990) A comparative case control study of colorectal cancer and adenoma. Cancer Sci 81:1101–1108
Zurück zum Zitat Ko JK, Leung CC (2010) Ginger extract and polaprezinc exert gastroprotective actions by anti-oxidant and growth factor modulating effects in rats. J Gastroenterol Hepatol 25:1861–1869CrossRefPubMed Ko JK, Leung CC (2010) Ginger extract and polaprezinc exert gastroprotective actions by anti-oxidant and growth factor modulating effects in rats. J Gastroenterol Hepatol 25:1861–1869CrossRefPubMed
Zurück zum Zitat Kuo C-C, Chen H-H, Chiang W (2012) Adlay (薏苡 yì yĭ;“soft-shelled job’s tears”; the seeds of Coix lachryma-jobi L. var. ma-yuen Stapf) is a potential cancer chemopreventive agent toward multistage carcinogenesis processes. J Tradit Complement Med 2:267–275CrossRefPubMedPubMedCentral Kuo C-C, Chen H-H, Chiang W (2012) Adlay (薏苡 yì yĭ;“soft-shelled job’s tears”; the seeds of Coix lachryma-jobi L. var. ma-yuen Stapf) is a potential cancer chemopreventive agent toward multistage carcinogenesis processes. J Tradit Complement Med 2:267–275CrossRefPubMedPubMedCentral
Zurück zum Zitat Li Y, Hu Y, Shi S, Jiang L (2014) Evaluation of antioxidant and immuno-enhancing activities of Purslane polysaccharides in gastric cancer rats. Int J Biol Macromol 68:113–116CrossRefPubMed Li Y, Hu Y, Shi S, Jiang L (2014) Evaluation of antioxidant and immuno-enhancing activities of Purslane polysaccharides in gastric cancer rats. Int J Biol Macromol 68:113–116CrossRefPubMed
Zurück zum Zitat Li J, Jiang K, Zhao F (2015) Oxymatrine suppresses proliferation and facilitates apoptosis of human ovarian cancer cells through upregulating microRNA-29b and downregulating matrix metalloproteinase-2 expression. Molecular medicine reports 12:5369–5374PubMed Li J, Jiang K, Zhao F (2015) Oxymatrine suppresses proliferation and facilitates apoptosis of human ovarian cancer cells through upregulating microRNA-29b and downregulating matrix metalloproteinase-2 expression. Molecular medicine reports 12:5369–5374PubMed
Zurück zum Zitat Liu Y, Xu Y, Ji W, Li X, Sun B, Gao Q, Su C (2014) Anti-tumor activities of matrine and oxymatrine: literature review. Tumor Biol 35:5111–5119CrossRef Liu Y, Xu Y, Ji W, Li X, Sun B, Gao Q, Su C (2014) Anti-tumor activities of matrine and oxymatrine: literature review. Tumor Biol 35:5111–5119CrossRef
Zurück zum Zitat Liu N, Sun B, Wu P, Wei X (2015a) Chemopreventive effects of Azadirachta indica on cancer marker indices and ultrastructural changes during 1, 2-dimethylhydrazine-induced colon carcinogenesis in rats. Cell biochemistry and biophysics:1–6 Liu N, Sun B, Wu P, Wei X (2015a) Chemopreventive effects of Azadirachta indica on cancer marker indices and ultrastructural changes during 1, 2-dimethylhydrazine-induced colon carcinogenesis in rats. Cell biochemistry and biophysics:1–6
Zurück zum Zitat Liu Y, Wang J, Wang W, Zhang H, Zhang X, Han C (2015b) The chemical constituents and pharmacological actions of Cordyceps sinensis. Evidence-Based Complement Altern Med. doi:10.1155/2015/575063 Liu Y, Wang J, Wang W, Zhang H, Zhang X, Han C (2015b) The chemical constituents and pharmacological actions of Cordyceps sinensis. Evidence-Based Complement Altern Med. doi:10.​1155/​2015/​575063
Zurück zum Zitat Lopes-da-Silva F, de Pascual-Teresa S, Rivas-Gonzalo J, Santos-Buelga C (2002) Identification of anthocyanin pigments in strawberry (cv Camarosa) by LC using DAD and ESI-MS detection. Eur Food Res Technol 214:248–253CrossRef Lopes-da-Silva F, de Pascual-Teresa S, Rivas-Gonzalo J, Santos-Buelga C (2002) Identification of anthocyanin pigments in strawberry (cv Camarosa) by LC using DAD and ESI-MS detection. Eur Food Res Technol 214:248–253CrossRef
Zurück zum Zitat Lu B, Xu L, Yu L, Zhang L (2008) Extract of radix curcumae prevents gastric cancer in rats. Digestion 77:87–91CrossRefPubMed Lu B, Xu L, Yu L, Zhang L (2008) Extract of radix curcumae prevents gastric cancer in rats. Digestion 77:87–91CrossRefPubMed
Zurück zum Zitat Lu B, Yu L, Xu L, Chen H, Zhang L, Zeng Y (2010) The effects of radix curcumae extract on expressions of VEGF, COX-2 and PCNA in gastric mucosa of rats fed with MNNG. Curr Pharm Biotechnol 11:313–317CrossRefPubMed Lu B, Yu L, Xu L, Chen H, Zhang L, Zeng Y (2010) The effects of radix curcumae extract on expressions of VEGF, COX-2 and PCNA in gastric mucosa of rats fed with MNNG. Curr Pharm Biotechnol 11:313–317CrossRefPubMed
Zurück zum Zitat Lu J-J, Dang Y-Y, Huang M, Xu W-S, Chen X-P, Wang Y-T (2012) Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae—a review. J Ethnopharmacol 143:406–411CrossRefPubMed Lu J-J, Dang Y-Y, Huang M, Xu W-S, Chen X-P, Wang Y-T (2012) Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae—a review. J Ethnopharmacol 143:406–411CrossRefPubMed
Zurück zum Zitat Magesh V, Singh JPV, Selvendiran K, Ekambaram G, Sakthisekaran D (2006) Antitumour activity of crocetin in accordance to tumor incidence, antioxidant status, drug metabolizing enzymes and histopathological studies. Mol Cell Biochem 287:127–135CrossRefPubMed Magesh V, Singh JPV, Selvendiran K, Ekambaram G, Sakthisekaran D (2006) Antitumour activity of crocetin in accordance to tumor incidence, antioxidant status, drug metabolizing enzymes and histopathological studies. Mol Cell Biochem 287:127–135CrossRefPubMed
Zurück zum Zitat Manikandan P, Vidjaya LP, Prathiba D, Nagini S (2008) Combinatorial chemopreventive effect of Azadirachta indica and Ocimum sanctum on oxidant-antioxidant status, cell proliferation, apoptosis and angiogenesis in a rat forestomach carcinogenesis model. Singap Med J 49:814–822 Manikandan P, Vidjaya LP, Prathiba D, Nagini S (2008) Combinatorial chemopreventive effect of Azadirachta indica and Ocimum sanctum on oxidant-antioxidant status, cell proliferation, apoptosis and angiogenesis in a rat forestomach carcinogenesis model. Singap Med J 49:814–822
Zurück zum Zitat Marchbank T, Ojobo E, Playford CJ, Playford RJ (2011) Reparative properties of the traditional Chinese medicine Cordyceps sinensis (Chinese caterpillar mushroom) using HT29 cell culture and rat gastric damage models of injury. Br J Nutr 105:1303–1310CrossRefPubMed Marchbank T, Ojobo E, Playford CJ, Playford RJ (2011) Reparative properties of the traditional Chinese medicine Cordyceps sinensis (Chinese caterpillar mushroom) using HT29 cell culture and rat gastric damage models of injury. Br J Nutr 105:1303–1310CrossRefPubMed
Zurück zum Zitat Mei Y, Wei D, Liu J (2005) Modulation effect of tea polyphenol toward N-methyl-N′-nitro-N-nitrosoguanidine-induced precancerous gastric lesion in rats. J Nutr Biochem 16:172–177CrossRefPubMed Mei Y, Wei D, Liu J (2005) Modulation effect of tea polyphenol toward N-methyl-N′-nitro-N-nitrosoguanidine-induced precancerous gastric lesion in rats. J Nutr Biochem 16:172–177CrossRefPubMed
Zurück zum Zitat Mohammad Alizadeh A et al (2015) Chemoprotection of MNNG-initiated gastric cancer in rats using Iranian propolis. Arch Iranian Med(AIM) 18:18–23 Mohammad Alizadeh A et al (2015) Chemoprotection of MNNG-initiated gastric cancer in rats using Iranian propolis. Arch Iranian Med(AIM) 18:18–23
Zurück zum Zitat Murugan RS, Mohan KVPC, Uchida K, Hara Y, Prathiba D, Nagini S (2007) Modulatory effects of black tea polyphenols on oxidant–antioxidant profile and expression of proliferation, apoptosis, and angiogenesis-associated proteins in the rat forestomach carcinogenesis model. J Gastroenterol 42:352–361CrossRefPubMed Murugan RS, Mohan KVPC, Uchida K, Hara Y, Prathiba D, Nagini S (2007) Modulatory effects of black tea polyphenols on oxidant–antioxidant profile and expression of proliferation, apoptosis, and angiogenesis-associated proteins in the rat forestomach carcinogenesis model. J Gastroenterol 42:352–361CrossRefPubMed
Zurück zum Zitat Narisawa T, Fukaura Y (1993) A very low dose of green tea polyphenols in drinking water prevents N-methyl-N-nitrosourea-induced colon carcinogenesis in F344 rats. Jpn J Cancer Res 84:1007–1009CrossRefPubMed Narisawa T, Fukaura Y (1993) A very low dose of green tea polyphenols in drinking water prevents N-methyl-N-nitrosourea-induced colon carcinogenesis in F344 rats. Jpn J Cancer Res 84:1007–1009CrossRefPubMed
Zurück zum Zitat Paul R, Prasad M, Sah NK (2011) Anticancer biology of Azadirachta indica L (neem): a mini review. Cancer Biol Ther 12:467–476CrossRefPubMed Paul R, Prasad M, Sah NK (2011) Anticancer biology of Azadirachta indica L (neem): a mini review. Cancer Biol Ther 12:467–476CrossRefPubMed
Zurück zum Zitat Poma A, Fontecchio G, Carlucci G, Chichiricco G (2012) Anti-inflammatory properties of drugs from saffron crocus. Antiinflamm Antiallergy Agents Med Chem 11:37–51CrossRefPubMed Poma A, Fontecchio G, Carlucci G, Chichiricco G (2012) Anti-inflammatory properties of drugs from saffron crocus. Antiinflamm Antiallergy Agents Med Chem 11:37–51CrossRefPubMed
Zurück zum Zitat Posadzki P, Watson L, Ernst E (2013) Herb–drug interactions: an overview of systematic reviews. Br J Clin Pharmacol 75:603–618PubMedPubMedCentral Posadzki P, Watson L, Ernst E (2013) Herb–drug interactions: an overview of systematic reviews. Br J Clin Pharmacol 75:603–618PubMedPubMedCentral
Zurück zum Zitat Shi X-Y, Zhao F-Z, Dai X, Ma L-S, Dong X-Y, Fang J (2002) Effect of jianpiyiwei capsule on gastric precancerous lesions in rats. World J Gastroenterol 8:608–612CrossRefPubMedPubMedCentral Shi X-Y, Zhao F-Z, Dai X, Ma L-S, Dong X-Y, Fang J (2002) Effect of jianpiyiwei capsule on gastric precancerous lesions in rats. World J Gastroenterol 8:608–612CrossRefPubMedPubMedCentral
Zurück zum Zitat Sohn YA et al (2015) Protective effect of liriodendrin isolated from Kalopanax pictus against gastric injury. Biomol Ther 23:53–59CrossRef Sohn YA et al (2015) Protective effect of liriodendrin isolated from Kalopanax pictus against gastric injury. Biomol Ther 23:53–59CrossRef
Zurück zum Zitat Tao L, Zhou L, Zheng L, Yao M (2006) Elemene displays anti-cancer ability on laryngeal cancer cells in vitro and in vivo. Cancer Chemother Pharmacol 58:24–34CrossRefPubMed Tao L, Zhou L, Zheng L, Yao M (2006) Elemene displays anti-cancer ability on laryngeal cancer cells in vitro and in vivo. Cancer Chemother Pharmacol 58:24–34CrossRefPubMed
Zurück zum Zitat Tomita H et al (2008) Preventive effect of fermented brown rice and rice bran on N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats. Oncol Rep 19:11–15PubMed Tomita H et al (2008) Preventive effect of fermented brown rice and rice bran on N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats. Oncol Rep 19:11–15PubMed
Zurück zum Zitat Toreti VC, Sato HH, Pastore GM (2013) Park YK (2013) Recent progress of propolis for its biological and chemical compositions and its botanical origin. Evidence-Based Complement Altern Med. doi:10.1155/2013/697390 Toreti VC, Sato HH, Pastore GM (2013) Park YK (2013) Recent progress of propolis for its biological and chemical compositions and its botanical origin. Evidence-Based Complement Altern Med. doi:10.​1155/​2013/​697390
Zurück zum Zitat Tseng T-H, Chu C-Y, Huang J-M, Shiow S-J, Wang C-J (1995) Crocetin protects against oxidative damage in rat primary hepatocytes. Cancer Lett 97:61–67CrossRefPubMed Tseng T-H, Chu C-Y, Huang J-M, Shiow S-J, Wang C-J (1995) Crocetin protects against oxidative damage in rat primary hepatocytes. Cancer Lett 97:61–67CrossRefPubMed
Zurück zum Zitat Tsuboi K et al (2014) Zerumbone inhibits tumor angiogenesis via NF-κB in gastric cancer. Oncol Rep 31:57–64PubMed Tsuboi K et al (2014) Zerumbone inhibits tumor angiogenesis via NF-κB in gastric cancer. Oncol Rep 31:57–64PubMed
Zurück zum Zitat Wang G et al (2005) Antitumor effect of β-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death. Cell Mol Life Sci CMLS 62:881–893CrossRefPubMed Wang G et al (2005) Antitumor effect of β-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death. Cell Mol Life Sci CMLS 62:881–893CrossRefPubMed
Zurück zum Zitat Wang Z, Hasegawa J, Wang X, Matsuda A, Tokuda T, Miura N, Watanabe T (2011) Protective effects of ginger against aspirin-induced gastric ulcers in rats. Yonago acta medica 54:11–19PubMedPubMedCentral Wang Z, Hasegawa J, Wang X, Matsuda A, Tokuda T, Miura N, Watanabe T (2011) Protective effects of ginger against aspirin-induced gastric ulcers in rats. Yonago acta medica 54:11–19PubMedPubMedCentral
Zurück zum Zitat Wang L, Sun J, Yi Q, Wang X, Ju X (2012) Protective effect of polyphenols extract of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on hypercholesterolemia-induced oxidative stress in rats. Molecules 17:8886–8897CrossRefPubMed Wang L, Sun J, Yi Q, Wang X, Ju X (2012) Protective effect of polyphenols extract of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on hypercholesterolemia-induced oxidative stress in rats. Molecules 17:8886–8897CrossRefPubMed
Zurück zum Zitat Wang B, Han Q, Zhu Y (2015) Oxymatrine inhibited cell proliferation by inducing apoptosis in human lung cancer A549 cells. Bio-Med Mater Eng 26:165–172CrossRef Wang B, Han Q, Zhu Y (2015) Oxymatrine inhibited cell proliferation by inducing apoptosis in human lung cancer A549 cells. Bio-Med Mater Eng 26:165–172CrossRef
Zurück zum Zitat Werba PJ et al (2015) Overview of green tea interaction with cardiovascular drugs. Curr Pharm Des 21:1213–1219CrossRefPubMed Werba PJ et al (2015) Overview of green tea interaction with cardiovascular drugs. Curr Pharm Des 21:1213–1219CrossRefPubMed
Zurück zum Zitat Wu C, Huang W, Guo Y, Xia P, Sun X, Pan X, Hu W (2015) Oxymatrine inhibits the proliferation of prostate cancer cells in vitro and in vivo. Mol Med Rep 11:4129–4134PubMedPubMedCentral Wu C, Huang W, Guo Y, Xia P, Sun X, Pan X, Hu W (2015) Oxymatrine inhibits the proliferation of prostate cancer cells in vitro and in vivo. Mol Med Rep 11:4129–4134PubMedPubMedCentral
Zurück zum Zitat Xu Q, Jin X, Ran Z, Yang C, Xiao S (2007) Chemopreventive effect of oxymatrine on N-methyl-N'-nitro-N-nitrosoguanidine induced gastrointestinal cancer: experiment with rats. Zhonghua yi xue za zhi 87:855–858PubMed Xu Q, Jin X, Ran Z, Yang C, Xiao S (2007) Chemopreventive effect of oxymatrine on N-methyl-N'-nitro-N-nitrosoguanidine induced gastrointestinal cancer: experiment with rats. Zhonghua yi xue za zhi 87:855–858PubMed
Zurück zum Zitat Yamane T et al (1995) Inhibition of N-methyl-N′-nitro-N-nitrosoguanidine-induced carcinogenesis by (−)-epigallocatechin gallate in the rat glandular stomach. Cancer Res 55:2081–2084PubMed Yamane T et al (1995) Inhibition of N-methyl-N′-nitro-N-nitrosoguanidine-induced carcinogenesis by (−)-epigallocatechin gallate in the rat glandular stomach. Cancer Res 55:2081–2084PubMed
Zurück zum Zitat Yance DR, Sagar SM (2006) Targeting angiogenesis with integrative cancer therapies. Integr Cancer Ther 5:9–29CrossRefPubMed Yance DR, Sagar SM (2006) Targeting angiogenesis with integrative cancer therapies. Integr Cancer Ther 5:9–29CrossRefPubMed
Zurück zum Zitat Yang W, Li W, Chen J, Chen X (2007) [Preventive effects of 4 Se-enriched plants on rat stomach cancer induced by MNNG--1. Inhibitary effects of different selenium resources on rat aneuploid cell incidence in mucosal epithelium of gastric antrum]. Wei sheng yan jiu. J Hygiene Res 36:612–614 Yang W, Li W, Chen J, Chen X (2007) [Preventive effects of 4 Se-enriched plants on rat stomach cancer induced by MNNG--1. Inhibitary effects of different selenium resources on rat aneuploid cell incidence in mucosal epithelium of gastric antrum]. Wei sheng yan jiu. J Hygiene Res 36:612–614
Zurück zum Zitat Yang CS, Wang X, Lu G, Picinich SC (2009) Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nat Rev Cancer 9:429–439CrossRefPubMedPubMedCentral Yang CS, Wang X, Lu G, Picinich SC (2009) Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nat Rev Cancer 9:429–439CrossRefPubMedPubMedCentral
Zurück zum Zitat Yu F, Gao J, Zeng Y, Liu CX (2011) Effects of adlay seed oil on blood lipids and antioxidant capacity in hyperlipidemic rats. J Sci Food Agric 91:1843–1848CrossRefPubMed Yu F, Gao J, Zeng Y, Liu CX (2011) Effects of adlay seed oil on blood lipids and antioxidant capacity in hyperlipidemic rats. J Sci Food Agric 91:1843–1848CrossRefPubMed
Zurück zum Zitat Zaghlool SS, Shehata BA, Abo-Seif AA, El-Latif HAA (2015) Protective effects of ginger and marshmallow extracts on indomethacin-induced peptic ulcer in rats. J Natur Sci biology Med 6:421–428CrossRef Zaghlool SS, Shehata BA, Abo-Seif AA, El-Latif HAA (2015) Protective effects of ginger and marshmallow extracts on indomethacin-induced peptic ulcer in rats. J Natur Sci biology Med 6:421–428CrossRef
Metadaten
Titel
Herbal remedies against gastric cancer in experimental rats
verfasst von
Aidin Shojaee Tabrizi
Marjan Mohammadi
Publikationsdatum
04.03.2016
Verlag
Springer London
Erschienen in
Comparative Clinical Pathology / Ausgabe 2/2017
Print ISSN: 1618-5641
Elektronische ISSN: 1618-565X
DOI
https://doi.org/10.1007/s00580-016-2239-8

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