Erschienen in:
01.06.2005 | Poster Presentation
Hereditary breast cancer – a spectrum of pathogenic mutations and unknown variants of BRCA1 and BRCA2 genes in the Czech Republic: efficiency of testing and clinical follow-up
verfasst von:
L Foretova, M Lukesova, P Vasickova, M Navratilova, H Pavlu, J Kuklova, V Urbankova, D Hanouskova, B Dvorackova, E Machackova
Erschienen in:
Breast Cancer Research
|
Sonderheft 2/2005
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Excerpt
Germline mutations in the highly penetrant cancer susceptibility genes BRCA1 and BRCA2 cause genetic predisposition to breast and ovarian cancers. Molecular genetic testing of pathogenic mutations in these two genes is an effective method for breast cancer risk prediction. Genetic counselling and testing has been provided to high-risk women in our institute since 1997. Until now 589 probands (580 women and nine men) with breast/ovarian cancer have been tested for BRCA1/2 germline mutations. …