Skip to main content
Erschienen in: InFo Hämatologie + Onkologie 5/2020

17.05.2020 | Herpesviren | Zertifizierte Fortbildung

Risiko bei HIV, Immunsuppression und Transplantationen

Opportunistische Infektionen durch humane Herpesviren*

verfasst von: Niklas Floß, Sebastian Dolff

Erschienen in: InFo Hämatologie + Onkologie | Ausgabe 5/2020

Einloggen, um Zugang zu erhalten

Auszug

Nicht nur infolge einer HIV-Erkrankung, sondern auch aufgrund einer Immunsuppression nach der Transplantation von allogenen Stammzellen oder Organen oder infolge einer onkologischen Therapie steigt das Risiko für eine Infektion mit Herpesviren. Lesen Sie in der folgenden Übersicht, was Sie zur Prophylaxe, Diagnostik und Therapie wissen müssen.
Literatur
1.
Zurück zum Zitat Fishman JA. Infection in Organ Transplantation. Am J Transplant. 2017;17(4):856-79 Fishman JA. Infection in Organ Transplantation. Am J Transplant. 2017;17(4):856-79
2.
Zurück zum Zitat Hellenbrand W et al. Seroprevalence of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in former East and West Germany, 1997-1998. Eur J Clin Microbiol Infect Dis. 2005;24(2):131-5 Hellenbrand W et al. Seroprevalence of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in former East and West Germany, 1997-1998. Eur J Clin Microbiol Infect Dis. 2005;24(2):131-5
3.
Zurück zum Zitat Kusne S et al. Herpes simplex virus hepatitis after solid organ transplantation in adults. J Infect Dis. 1991;163(5):1001-7 Kusne S et al. Herpes simplex virus hepatitis after solid organ transplantation in adults. J Infect Dis. 1991;163(5):1001-7
4.
Zurück zum Zitat Anderson NW et al. Light microscopy, culture, molecular, and serologic methods for detection of herpes simplex virus. J Clin Microbiol. 2014;52(1):2-8 Anderson NW et al. Light microscopy, culture, molecular, and serologic methods for detection of herpes simplex virus. J Clin Microbiol. 2014;52(1):2-8
5.
Zurück zum Zitat Gershon AA et al. A model of Lytic, latent, and reactivating Varicella-zoster virus infections in isolated enteric neurons. J Infect Dis. 2008;197 Suppl 2:S61-5 Gershon AA et al. A model of Lytic, latent, and reactivating Varicella-zoster virus infections in isolated enteric neurons. J Infect Dis. 2008;197 Suppl 2:S61-5
6.
Zurück zum Zitat Watson CPN et al. Postherpetic neuralgia: further post-mortem studies of cases with and without pain. Pain. 1991;44(2):105-17 Watson CPN et al. Postherpetic neuralgia: further post-mortem studies of cases with and without pain. Pain. 1991;44(2):105-17
7.
Zurück zum Zitat Elliott KJ. Taxonomy and mechanisms of neuropathic pain. Semin Neurol. 1994;14(3):195-205 Elliott KJ. Taxonomy and mechanisms of neuropathic pain. Semin Neurol. 1994;14(3):195-205
8.
Zurück zum Zitat Schmader K et al. Herpes zoster in older adults. Clin Infect Dis. 2001;32(10):1481-6 Schmader K et al. Herpes zoster in older adults. Clin Infect Dis. 2001;32(10):1481-6
9.
Zurück zum Zitat Buchbinder SP et al. Herpes zoster and human immunodeficiency virus infection. J Infect Dis. 1992;166(5):1153-6 Buchbinder SP et al. Herpes zoster and human immunodeficiency virus infection. J Infect Dis. 1992;166(5):1153-6
10.
Zurück zum Zitat Chen SY et al. Incidence of herpes zoster in patients with altered immune function. Infection. 2014;42(2):325-34 Chen SY et al. Incidence of herpes zoster in patients with altered immune function. Infection. 2014;42(2):325-34
11.
Zurück zum Zitat Rullán M et al. Efficacy of gabapentin for prevention of postherpetic neuralgia: study protocol for a randomized controlled clinical trial. Trials. 2017;18(1):24 Rullán M et al. Efficacy of gabapentin for prevention of postherpetic neuralgia: study protocol for a randomized controlled clinical trial. Trials. 2017;18(1):24
12.
Zurück zum Zitat Liesegang TJ. Herpes zoster ophthalmicus natural history, risk factors, clinical presentation, andmorbidity. Ophthalmology. 2008;115(2 Suppl):S3-12 Liesegang TJ. Herpes zoster ophthalmicus natural history, risk factors, clinical presentation, andmorbidity. Ophthalmology. 2008;115(2 Suppl):S3-12
13.
Zurück zum Zitat Fleisher G et al. Life-threatening complications of varicella. Am J Dis Child. 1981;135(10):896-9 Fleisher G et al. Life-threatening complications of varicella. Am J Dis Child. 1981;135(10):896-9
14.
Zurück zum Zitat De Jong MD et al. Molecular diagnosis of visceral herpes zoster. Lancet. 2001;357(9274):2101-2 De Jong MD et al. Molecular diagnosis of visceral herpes zoster. Lancet. 2001;357(9274):2101-2
15.
Zurück zum Zitat Stranska R et al. Routine use of a highly automated and internally controlled real-time PCR assay for the diagnosis of herpes simplex and varicella-zoster virus infections. J Clin Virol. 2004;30(1):39-44 Stranska R et al. Routine use of a highly automated and internally controlled real-time PCR assay for the diagnosis of herpes simplex and varicella-zoster virus infections. J Clin Virol. 2004;30(1):39-44
16.
Zurück zum Zitat https://www.onkopedia.com/de/onkopedia/guidelines/antivirale-prophylaxe/@@guideline/html/index.html abgerufen am 24. April 2020 https://www.onkopedia.com/de/onkopedia/guidelines/antivirale-prophylaxe/@@guideline/html/index.html abgerufen am 24. April 2020
17.
Zurück zum Zitat Mikulska M et al. ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Agents targeting lymphoid cells surface antigens [I]: CD19, CD20 and CD52). Clin Microbiol Infect. 2018;24 Suppl 2:S71-S82 Mikulska M et al. ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Agents targeting lymphoid cells surface antigens [I]: CD19, CD20 and CD52). Clin Microbiol Infect. 2018;24 Suppl 2:S71-S82
18.
Zurück zum Zitat Murawski N et al. Anti-infective prophylaxis with aciclovir and cotrimoxazole to reduce the rate of infections and therapy-associated deaths in elderly patients with DLBCL undergoing R-CHOP immunochemotherapy. J Clin Oncol. 2017;35(15_suppl):7539 Murawski N et al. Anti-infective prophylaxis with aciclovir and cotrimoxazole to reduce the rate of infections and therapy-associated deaths in elderly patients with DLBCL undergoing R-CHOP immunochemotherapy. J Clin Oncol. 2017;35(15_suppl):7539
19.
Zurück zum Zitat Pfreundschuh M et al. Optimization of rituximab for the treatment of diffuse large B-cell lymphoma (II): extended rituximab exposure time in the SMARTE-R-CHOP-14 trial of the german high-grade non-Hodgkin lymphoma study group. J Clin Oncol. 2014;32(36):4127-33 Pfreundschuh M et al. Optimization of rituximab for the treatment of diffuse large B-cell lymphoma (II): extended rituximab exposure time in the SMARTE-R-CHOP-14 trial of the german high-grade non-Hodgkin lymphoma study group. J Clin Oncol. 2014;32(36):4127-33
20.
Zurück zum Zitat Maschmeyer G et al. Infections associated with immunotherapeutic and molecular targeted agents in hematology and oncology. A position paper by the European Conference on Infections in Leukemia (ECIL). Leukemia. 2019;33(4):844-62 Maschmeyer G et al. Infections associated with immunotherapeutic and molecular targeted agents in hematology and oncology. A position paper by the European Conference on Infections in Leukemia (ECIL). Leukemia. 2019;33(4):844-62
21.
Zurück zum Zitat Yakoub-Agha I et al. Management of adults and children undergoing chimeric antigen receptor T-cell therapy: best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE). Haematologica. 2020;105(2):297-316 Yakoub-Agha I et al. Management of adults and children undergoing chimeric antigen receptor T-cell therapy: best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE). Haematologica. 2020;105(2):297-316
22.
Zurück zum Zitat Ullmann AJ et al. Infectious diseases in allogeneic haematopoietic stem cell transplantation: prevention and prophylaxis strategy guidelines 2016. Ann Hematol. 2016;95(9):1435-55 Ullmann AJ et al. Infectious diseases in allogeneic haematopoietic stem cell transplantation: prevention and prophylaxis strategy guidelines 2016. Ann Hematol. 2016;95(9):1435-55
23.
Zurück zum Zitat Robert-Koch-Institut. Mitteilung der Ständigen Impfkommission (STIKO) beim RKI. Wissenschaftliche Begründung zur Empfehlung einer Impfung mit dem Herpes zoster-subunit-Totimpfstoff. Epid Bull. 2018;(50):541-66 Robert-Koch-Institut. Mitteilung der Ständigen Impfkommission (STIKO) beim RKI. Wissenschaftliche Begründung zur Empfehlung einer Impfung mit dem Herpes zoster-subunit-Totimpfstoff. Epid Bull. 2018;(50):541-66
24.
Zurück zum Zitat Crawford DH. Biology and disease associations of Epstein-Barr virus. Philos Trans R Soc Lond B Biol Sci. 2001;356(1408):461-73 Crawford DH. Biology and disease associations of Epstein-Barr virus. Philos Trans R Soc Lond B Biol Sci. 2001;356(1408):461-73
25.
Zurück zum Zitat Hanto DW. Classification of Epstein-Barr virus-associated posttransplant lymphoproliferative diseases: implications for understanding their pathogenesis and developing rational treatment strategies. Annu Rev Med. 1995;46:381-94 Hanto DW. Classification of Epstein-Barr virus-associated posttransplant lymphoproliferative diseases: implications for understanding their pathogenesis and developing rational treatment strategies. Annu Rev Med. 1995;46:381-94
26.
Zurück zum Zitat Capello D et al. Analysis of immunoglobulin heavy and light chain variable genes in post-transplant lymphoproliferative disorders. Hematol Oncol. 2006;24(4):212-9 Capello D et al. Analysis of immunoglobulin heavy and light chain variable genes in post-transplant lymphoproliferative disorders. Hematol Oncol. 2006;24(4):212-9
27.
Zurück zum Zitat Wagner HJ et al. Patients at risk for development of posttransplant lymphoproliferative disorder: Plasma versus peripheral blood mononuclear cells as material for quantification of Epstein-Barr viral load by using real-time quantitative polymerase chain reaction. Transplantation. 2001;72(6):1012-9 Wagner HJ et al. Patients at risk for development of posttransplant lymphoproliferative disorder: Plasma versus peripheral blood mononuclear cells as material for quantification of Epstein-Barr viral load by using real-time quantitative polymerase chain reaction. Transplantation. 2001;72(6):1012-9
28.
Zurück zum Zitat Enders G et al. Zytomegalievirus- (CMV-)Durchseuchung und Häufigkeit von CMV-Primärinfektionen bei schwangeren Frauen in Deutschland. Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz. 2003;46(5):426-32 Enders G et al. Zytomegalievirus- (CMV-)Durchseuchung und Häufigkeit von CMV-Primärinfektionen bei schwangeren Frauen in Deutschland. Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz. 2003;46(5):426-32
29.
Zurück zum Zitat Heinzerling L et al. Checkpoint-Inhibitoren: Diagnostik und Therapie von Nebenwirkungen. Dtsch Arztebl Int. 2019;116(8):119-126 Heinzerling L et al. Checkpoint-Inhibitoren: Diagnostik und Therapie von Nebenwirkungen. Dtsch Arztebl Int. 2019;116(8):119-126
30.
Zurück zum Zitat Kotton CN et al. The third international consensus guidelines on the management of Cytomegalovirus in solid-organ transplantation. Transplantation. 2018;102(6):900-31 Kotton CN et al. The third international consensus guidelines on the management of Cytomegalovirus in solid-organ transplantation. Transplantation. 2018;102(6):900-31
31.
Zurück zum Zitat Chou S. Newer methods for diagnosis of cytomegalovirus infection. Rev Infect Dis. 1990;12 Suppl 7:S727-36 Chou S. Newer methods for diagnosis of cytomegalovirus infection. Rev Infect Dis. 1990;12 Suppl 7:S727-36
32.
Zurück zum Zitat Gilbert C, Boivin G. Human cytomegalovirus resistance to antiviral drugs. Antimicrob Agents Chemother. 2005;49(3):873-83 Gilbert C, Boivin G. Human cytomegalovirus resistance to antiviral drugs. Antimicrob Agents Chemother. 2005;49(3):873-83
33.
Zurück zum Zitat Le Page AK et al. Clinical aspects of cytomegalovirus antiviral resistance in solid organ transplant recipients. Clin Infect Dis. 2013;56(7):1018-29 Le Page AK et al. Clinical aspects of cytomegalovirus antiviral resistance in solid organ transplant recipients. Clin Infect Dis. 2013;56(7):1018-29
34.
Zurück zum Zitat Witzke O, Hauser IA, Bartels M et al (2012) Valganciclovir prophylaxis versus preemptive therapyincytomegalovirus-positiverenalallograft recipients: 1-year results of a randomized clinical trial. Transplantation 93:61-68 Witzke O, Hauser IA, Bartels M et al (2012) Valganciclovir prophylaxis versus preemptive therapyincytomegalovirus-positiverenalallograft recipients: 1-year results of a randomized clinical trial. Transplantation 93:61-68
35.
Zurück zum Zitat Witzke O et al. Valganciclovir prophylaxis versus preemptive therapy in Cytomegalovirus-positive renal Allograft recipients: long-term results after 7 years of a randomized clinical trial. Transplantation. 2018;102(5):876-82 Witzke O et al. Valganciclovir prophylaxis versus preemptive therapy in Cytomegalovirus-positive renal Allograft recipients: long-term results after 7 years of a randomized clinical trial. Transplantation. 2018;102(5):876-82
36.
Zurück zum Zitat Marty FM et al. Letermovir prophylaxis for Cytomegalovirus in Hematopoietic-cell transplantation. N Engl J Med. 2017;377(25):2433-444 Marty FM et al. Letermovir prophylaxis for Cytomegalovirus in Hematopoietic-cell transplantation. N Engl J Med. 2017;377(25):2433-444
37.
Zurück zum Zitat Bowman LJ et al. Letermovir for the management of cytomegalovirus infection. Expert Opin Investig Drugs. 2017;26(2):235-241 Bowman LJ et al. Letermovir for the management of cytomegalovirus infection. Expert Opin Investig Drugs. 2017;26(2):235-241
38.
Zurück zum Zitat Maertens J et al. Maribavir for Preemptive Treatment of Cytomegalovirus Reactivation. N Engl J Med. 2019;381(12):1136-47 Maertens J et al. Maribavir for Preemptive Treatment of Cytomegalovirus Reactivation. N Engl J Med. 2019;381(12):1136-47
39.
Zurück zum Zitat Agut H, Bonnafous P, Gautheret-Dejean A (2017) Update on infections with human herpesviruses 6A, 6B, and 7. Med Mal Infect. 2017;47(2):83-91 Agut H, Bonnafous P, Gautheret-Dejean A (2017) Update on infections with human herpesviruses 6A, 6B, and 7. Med Mal Infect. 2017;47(2):83-91
40.
Zurück zum Zitat Eliassen E et al. Human Herpesvirus 6 and malignancy: a review. Front Oncol. 2018;8:512 Eliassen E et al. Human Herpesvirus 6 and malignancy: a review. Front Oncol. 2018;8:512
41.
Zurück zum Zitat Cesarman E et al. Kaposi sarcoma. Nat Rev Dis Primers. 2019;5(1):9 Cesarman E et al. Kaposi sarcoma. Nat Rev Dis Primers. 2019;5(1):9
Metadaten
Titel
Risiko bei HIV, Immunsuppression und Transplantationen
Opportunistische Infektionen durch humane Herpesviren*
verfasst von
Niklas Floß
Sebastian Dolff
Publikationsdatum
17.05.2020
Verlag
Springer Medizin
Erschienen in
InFo Hämatologie + Onkologie / Ausgabe 5/2020
Print ISSN: 2662-1754
Elektronische ISSN: 2662-1762
DOI
https://doi.org/10.1007/s15004-020-8095-3

Weitere Artikel der Ausgabe 5/2020

InFo Hämatologie + Onkologie 5/2020 Zur Ausgabe