Skip to main content
Erschienen in: Zeitschrift für Herz-,Thorax- und Gefäßchirurgie 2/2023

24.03.2023 | Herzunterstützungssystem | CME

Der Patient am linksventrikulären Assist Device

Spezielle Aspekte der medizinischen Versorgung außerhalb der Herzchirurgie

verfasst von: PD Dr. Jasmin S. Hanke, Dr. Ali Saad Merzah, Jashar Arfai, Prof. Dr. Axel Haverich, Prof. Dr. Jan D. Schmitto, Dr. Günes Dogan

Erschienen in: Zeitschrift für Herz-,Thorax- und Gefäßchirurgie | Ausgabe 2/2023

zum CME-Kurs Einloggen, um Zugang zu erhalten

Zusammenfassung

Herzunterstützungssysteme der neuesten Generation ermöglichen heutzutage erfolgreiche Therapiezeiten von mehreren Jahren. Eine große Anzahl der Patienten wird mittlerweile nicht mehr mit dem Ziel der Überbrückung bis zur Herztransplantation, sondern mit einer dauerhaften Therapie, „destination therapy“, versorgt. Trotz medizinischer und technischer Verbesserungen bleibt die Behandlung von Patienten mit einem Herzunterstützungssystem außerhalb herzchirurgischer Einheiten aufgrund der häufig bestehenden Multimorbidität sowie hämodynamischer und technischer Besonderheiten weiterhin eine Herausforderung. Die enge Anbindung an ein interdisziplinäres Team aus spezialisierten Ärzten und Kunstherzkoordinatoren gewährleistet eine lebenslange Unterstützung bei der medizinischen Versorgung dieser Patienten.
Literatur
1.
Zurück zum Zitat Deutsche Gesellschaft für Kardiologie (DGK) Deutscher Herzbericht 2019 Deutsche Gesellschaft für Kardiologie (DGK) Deutscher Herzbericht 2019
2.
Zurück zum Zitat Kaduszkiewicz H, Gerste B, Eisele M et al (2014) Herzinsuffizienz: Epidemiologie und Versorgung. In: Klauber J, Günster C, Gerste B et al (Hrsg) Schwerpunkt: Depression. Schattauer, Stuttgart, 209–229 Kaduszkiewicz H, Gerste B, Eisele M et al (2014) Herzinsuffizienz: Epidemiologie und Versorgung. In: Klauber J, Günster C, Gerste B et al (Hrsg) Schwerpunkt: Depression. Schattauer, Stuttgart, 209–229
3.
Zurück zum Zitat McDonagh TA, Metra M, Adamo M et al (2021) 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J 42:3599–3726PubMedCrossRef McDonagh TA, Metra M, Adamo M et al (2021) 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J 42:3599–3726PubMedCrossRef
4.
5.
Zurück zum Zitat Deutsche Herzstiftung (2019) Leben mit einem Kunstherz Deutsche Herzstiftung (2019) Leben mit einem Kunstherz
6.
Zurück zum Zitat Potapov EV, Antonides C, Crespo-Leiro MG et al (2019) EACTS expert consensus on long-term mechanical circulatory support. Eur J Cardiothorac Surg 2019(56):230–270CrossRef Potapov EV, Antonides C, Crespo-Leiro MG et al (2019) EACTS expert consensus on long-term mechanical circulatory support. Eur J Cardiothorac Surg 2019(56):230–270CrossRef
7.
Zurück zum Zitat Rose EA, Gelijns AC, Moskowitz AJ et al (2001) Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) Study Group. Long-term use of a left ventricular assist device for end-stage heart failure. N Engl J Med 345(20):1435–1443PubMedCrossRef Rose EA, Gelijns AC, Moskowitz AJ et al (2001) Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) Study Group. Long-term use of a left ventricular assist device for end-stage heart failure. N Engl J Med 345(20):1435–1443PubMedCrossRef
8.
Zurück zum Zitat Schmitto JD, Hanke JS, Rojas S et al (2015) Circulatory support exceeding five years with a continuous-flow left ventricular assist device for advanced heart failure patients. J Cardiothorac Surg 10:107PubMedPubMedCentralCrossRef Schmitto JD, Hanke JS, Rojas S et al (2015) Circulatory support exceeding five years with a continuous-flow left ventricular assist device for advanced heart failure patients. J Cardiothorac Surg 10:107PubMedPubMedCentralCrossRef
9.
Zurück zum Zitat Bundesärztekammer (Hrsg) (2021) Richtlinie gem. § 16 Abs. 1 S. 1 Nrn. 2 u. 5 TPG für die Wartelistenführung und Organvermittlung zur Herz- und Herz-Lungen-Transplantation. Dtsch Arztebl 118(35–36):A-1614/B-1338 Bundesärztekammer (Hrsg) (2021) Richtlinie gem. § 16 Abs. 1 S. 1 Nrn. 2 u. 5 TPG für die Wartelistenführung und Organvermittlung zur Herz- und Herz-Lungen-Transplantation. Dtsch Arztebl 118(35–36):A-1614/B-1338
10.
Zurück zum Zitat Mehra MR, Canter CE, Hannan MM et al (2016) The 2016 International Society for Heart Lung Transplantation listing criteria for heart transplantation: a 10-year update. J Heart Lung Transplant 35(1):1–23PubMedCrossRef Mehra MR, Canter CE, Hannan MM et al (2016) The 2016 International Society for Heart Lung Transplantation listing criteria for heart transplantation: a 10-year update. J Heart Lung Transplant 35(1):1–23PubMedCrossRef
11.
Zurück zum Zitat Lee SJ, Kim KH, Hong SK et al (2017) Evaluation of a heart transplant candidate. Curr Cardiol Rep 19(12):133PubMedCrossRef Lee SJ, Kim KH, Hong SK et al (2017) Evaluation of a heart transplant candidate. Curr Cardiol Rep 19(12):133PubMedCrossRef
12.
Zurück zum Zitat de By TMMH, Schoenrath F, Veen KM et al (2022) The European registry for patients with mechanical circulatory support of the European association for cardio-thoracic surgery: third report. Eur J Cardiothorac Surg 62(1):ezac32PubMedCrossRef de By TMMH, Schoenrath F, Veen KM et al (2022) The European registry for patients with mechanical circulatory support of the European association for cardio-thoracic surgery: third report. Eur J Cardiothorac Surg 62(1):ezac32PubMedCrossRef
13.
Zurück zum Zitat Shah P, Yuzefpolskaya M, Hickey GW et al (2022) Twelfth interagency registry for mechanically assisted circulatory support report: readmissions after left ventricular assist device. Ann Thorac Surg 113(3):722–737PubMedPubMedCentralCrossRef Shah P, Yuzefpolskaya M, Hickey GW et al (2022) Twelfth interagency registry for mechanically assisted circulatory support report: readmissions after left ventricular assist device. Ann Thorac Surg 113(3):722–737PubMedPubMedCentralCrossRef
16.
Zurück zum Zitat Gummert JF, Haverich A, Schmitto JD (2019) Dtsch Arztebl Int 116:843–848PubMed Gummert JF, Haverich A, Schmitto JD (2019) Dtsch Arztebl Int 116:843–848PubMed
17.
Zurück zum Zitat Kim YK, Balcetis N, Novitch R et al (2020) Risk factors of readmission to acute care hospital among individuals with heart failure and left ventricular assist device (LVAD) at inpatient rehabilitation setting (STROBE compliant article). Medicine 99(52):e23618PubMedPubMedCentralCrossRef Kim YK, Balcetis N, Novitch R et al (2020) Risk factors of readmission to acute care hospital among individuals with heart failure and left ventricular assist device (LVAD) at inpatient rehabilitation setting (STROBE compliant article). Medicine 99(52):e23618PubMedPubMedCentralCrossRef
18.
Zurück zum Zitat Vidula H, Takeda K, Estep JD et al (2022) Hospitalization patterns and impact of a magnetically-levitated left ventricular assist device in the MOMENTUM 3 trial. JACC Heart Fail 10(7):470–481PubMedCrossRef Vidula H, Takeda K, Estep JD et al (2022) Hospitalization patterns and impact of a magnetically-levitated left ventricular assist device in the MOMENTUM 3 trial. JACC Heart Fail 10(7):470–481PubMedCrossRef
19.
Zurück zum Zitat Beetz O, Bajunaid A, Meißler L et al (2020) Abdominal surgery in patients with ventricular assist devices: a single-center report. ASAIO J 66(8):890–898PubMedCrossRef Beetz O, Bajunaid A, Meißler L et al (2020) Abdominal surgery in patients with ventricular assist devices: a single-center report. ASAIO J 66(8):890–898PubMedCrossRef
20.
Zurück zum Zitat McElderry B, Alvarez P, Hanna M et al (2022) Outcomes of bariatric surgery in patients with left ventricular assist device. J Heart Lung Transplant 41(7):914–918PubMedCrossRef McElderry B, Alvarez P, Hanna M et al (2022) Outcomes of bariatric surgery in patients with left ventricular assist device. J Heart Lung Transplant 41(7):914–918PubMedCrossRef
21.
Zurück zum Zitat Eghrari AO, Rivers RJ, Alkharashi M et al (2014) Cataract surgery in patients with left ventricular assist device support. J Cataract Refract Surg 40(4):675–678PubMedCrossRef Eghrari AO, Rivers RJ, Alkharashi M et al (2014) Cataract surgery in patients with left ventricular assist device support. J Cataract Refract Surg 40(4):675–678PubMedCrossRef
22.
Zurück zum Zitat Mentias A, Briasoulis A, Vaughan Sarrazin MS et al (2020) Trends, Perioperative adverse events, and survival of patients with left ventricular assist devices undergoing Noncardiac surgery. JAMA Netw Open 3(11):e2025118PubMedPubMedCentralCrossRef Mentias A, Briasoulis A, Vaughan Sarrazin MS et al (2020) Trends, Perioperative adverse events, and survival of patients with left ventricular assist devices undergoing Noncardiac surgery. JAMA Netw Open 3(11):e2025118PubMedPubMedCentralCrossRef
24.
Zurück zum Zitat Schmid C, Tjan TD, Etz C et al (2005) First clinical experience with the Incor left ventricular assist device. J Heart Lung Transplant 24(9):1188–1194PubMedCrossRef Schmid C, Tjan TD, Etz C et al (2005) First clinical experience with the Incor left ventricular assist device. J Heart Lung Transplant 24(9):1188–1194PubMedCrossRef
25.
Zurück zum Zitat Wieselthaler GM, O Driscoll G, Jansz P et al (2010) Initial clinical experience with a novel left ventricular assist device with a magnetically levitated rotor in a multi-institutional trial. J Heart Lung Transplant 29(11):1218–1225PubMedCrossRef Wieselthaler GM, O Driscoll G, Jansz P et al (2010) Initial clinical experience with a novel left ventricular assist device with a magnetically levitated rotor in a multi-institutional trial. J Heart Lung Transplant 29(11):1218–1225PubMedCrossRef
26.
Zurück zum Zitat Rogers JG, Pagani FD, Tatooles AJ et al (2017) Intrapericardial left ventricular assist device for advanced heart failure. N Engl J Med 376:451–460PubMedCrossRef Rogers JG, Pagani FD, Tatooles AJ et al (2017) Intrapericardial left ventricular assist device for advanced heart failure. N Engl J Med 376:451–460PubMedCrossRef
27.
Zurück zum Zitat Schmitto JD, Hanke JS, Rojas SV et al (2015) First implantation in man of a new magnetically levitated left ventricular assist device (HeartMate III). J Heart Lung Transplant 34(6):858–860PubMedCrossRef Schmitto JD, Hanke JS, Rojas SV et al (2015) First implantation in man of a new magnetically levitated left ventricular assist device (HeartMate III). J Heart Lung Transplant 34(6):858–860PubMedCrossRef
28.
Zurück zum Zitat Mehra MR, Uriel N, Naka Y et al (2019) A fully magnetically levitated left ventricular assist device-final report. N Engl J Med 380:1618–1627PubMedCrossRef Mehra MR, Uriel N, Naka Y et al (2019) A fully magnetically levitated left ventricular assist device-final report. N Engl J Med 380:1618–1627PubMedCrossRef
29.
Zurück zum Zitat Hanke JS, Dogan G, Zoch A et al (2018) One-year outcomes with the HeartMate 3 left ventricular assist device. J Thorac Cardiovasc Surg 156(2):662–669PubMedCrossRef Hanke JS, Dogan G, Zoch A et al (2018) One-year outcomes with the HeartMate 3 left ventricular assist device. J Thorac Cardiovasc Surg 156(2):662–669PubMedCrossRef
30.
Zurück zum Zitat Netuka I, Sood P, Pya Y et al (2015) Fully magnetically levitated left ventricular assist system for treating advanced HF: a multicenter study. J Am Coll Cardiol 66(23):2579–2589PubMedCrossRef Netuka I, Sood P, Pya Y et al (2015) Fully magnetically levitated left ventricular assist system for treating advanced HF: a multicenter study. J Am Coll Cardiol 66(23):2579–2589PubMedCrossRef
31.
Zurück zum Zitat Mariani S, Hanke JS, Li T et al (2019) Device profile of the heartware HVAD system as a bridge-to-transplantation in patients with advanced heart failure: overview of its safety and efficacy. Expert Rev Med Devices 16(12):1003–1015PubMedCrossRef Mariani S, Hanke JS, Li T et al (2019) Device profile of the heartware HVAD system as a bridge-to-transplantation in patients with advanced heart failure: overview of its safety and efficacy. Expert Rev Med Devices 16(12):1003–1015PubMedCrossRef
32.
Zurück zum Zitat Molina EJ, Shah P, Kiernan MS et al (2021) The society of thoracic surgeons Intermacs 2020 annual report. Ann Thorac Surg 111:778–792PubMedCrossRef Molina EJ, Shah P, Kiernan MS et al (2021) The society of thoracic surgeons Intermacs 2020 annual report. Ann Thorac Surg 111:778–792PubMedCrossRef
33.
Zurück zum Zitat Zhigalov K, Van den Eynde J, Chrosch T et al (2021) Outcomes of left ventricular assist device implantation for advanced heart failure in critically ill patients (INTERMACS 1 and 2): a retrospective study. Artif Organs 45(7):706–716PubMedCrossRef Zhigalov K, Van den Eynde J, Chrosch T et al (2021) Outcomes of left ventricular assist device implantation for advanced heart failure in critically ill patients (INTERMACS 1 and 2): a retrospective study. Artif Organs 45(7):706–716PubMedCrossRef
34.
Zurück zum Zitat Schmitto JD, Mariani S, Li T et al (2021) Five-year outcomes of patients supported with HeartMate 3: a single-centre experience. Eur J Cardiothorac Surg 59(6):1155–1163PubMedCrossRef Schmitto JD, Mariani S, Li T et al (2021) Five-year outcomes of patients supported with HeartMate 3: a single-centre experience. Eur J Cardiothorac Surg 59(6):1155–1163PubMedCrossRef
35.
Zurück zum Zitat Gross C, Schima H, Schlöglhofer T et al (2020) Continuous LVAD monitoring reveals high suction rates in clinically stable outpatients. Artif Organs 44(7):E251–E262PubMedPubMedCentralCrossRef Gross C, Schima H, Schlöglhofer T et al (2020) Continuous LVAD monitoring reveals high suction rates in clinically stable outpatients. Artif Organs 44(7):E251–E262PubMedPubMedCentralCrossRef
36.
Zurück zum Zitat Feldman D, Pamboukian SV, Teuteberg JJ et al (2013) The 2013 International Society for Heart and Lung Transplantation Guidelines for mechanical circulatory support: executive summary. J Heart Lung Transplant 32(2):157–187PubMedCrossRef Feldman D, Pamboukian SV, Teuteberg JJ et al (2013) The 2013 International Society for Heart and Lung Transplantation Guidelines for mechanical circulatory support: executive summary. J Heart Lung Transplant 32(2):157–187PubMedCrossRef
37.
Zurück zum Zitat Pilarczyk K, Boeken U, Beckmann A et al (2020) Empfehlungen zum Notfallmanagement von Patienten mit permanenten Herzunterstützungssystemen : Konsensuspapier der DGTHG, DIVI, DGIIN, DGAI, DGINA, DGfK und DGK [Recommendations for emergency management of patients with permanent mechanical circulatory support : Consensus statement of DGTHG, DIVI, DGIIN, DGAI, DGINA, DGfK and DGK]. Anaesthesist 69(4):238–253 (German)PubMedCrossRef Pilarczyk K, Boeken U, Beckmann A et al (2020) Empfehlungen zum Notfallmanagement von Patienten mit permanenten Herzunterstützungssystemen : Konsensuspapier der DGTHG, DIVI, DGIIN, DGAI, DGINA, DGfK und DGK [Recommendations for emergency management of patients with permanent mechanical circulatory support : Consensus statement of DGTHG, DIVI, DGIIN, DGAI, DGINA, DGfK and DGK]. Anaesthesist 69(4):238–253 (German)PubMedCrossRef
38.
Zurück zum Zitat Rame JE, Pagani FD, Kiernan MS et al (2021) Evolution of late right heart failure with left ventricular assist devices and association with outcomes. J Am Coll Cardiol 78(23):2294–2308PubMedCrossRef Rame JE, Pagani FD, Kiernan MS et al (2021) Evolution of late right heart failure with left ventricular assist devices and association with outcomes. J Am Coll Cardiol 78(23):2294–2308PubMedCrossRef
39.
Zurück zum Zitat Long B, Robertson J, Koyfman A et al (2019) Left ventricular assist devices and their complications: a review for emergency clinicians. Am J Emerg Med 37(8):1562–1570PubMedCrossRef Long B, Robertson J, Koyfman A et al (2019) Left ventricular assist devices and their complications: a review for emergency clinicians. Am J Emerg Med 37(8):1562–1570PubMedCrossRef
40.
Zurück zum Zitat Hwang KY, Hwang NC (2018) Facilitating noncardiac surgery for the patient with left ventricular assist device: a guide for the anesthesiologist. Ann Card Anaesth 21(4):351–362PubMedPubMedCentralCrossRef Hwang KY, Hwang NC (2018) Facilitating noncardiac surgery for the patient with left ventricular assist device: a guide for the anesthesiologist. Ann Card Anaesth 21(4):351–362PubMedPubMedCentralCrossRef
41.
Zurück zum Zitat Hickey KT, Colombo PC, Naka Y et al (2020) Atrial fibrillation is associated with recurrent ventricular arrhythmias after LVAD implant: incidence and impact in a consecutive series. J Cardiovasc Transl Res 13(2):199–203PubMedCrossRef Hickey KT, Colombo PC, Naka Y et al (2020) Atrial fibrillation is associated with recurrent ventricular arrhythmias after LVAD implant: incidence and impact in a consecutive series. J Cardiovasc Transl Res 13(2):199–203PubMedCrossRef
42.
Zurück zum Zitat Mott IH, Poulsen SH, Løgstrup BB (2020) Awake and aware with ongoing ventricular fibrillation during LVAD treatment: is it possible? BMJ Case Rep 13(4):e234527PubMedPubMedCentralCrossRef Mott IH, Poulsen SH, Løgstrup BB (2020) Awake and aware with ongoing ventricular fibrillation during LVAD treatment: is it possible? BMJ Case Rep 13(4):e234527PubMedPubMedCentralCrossRef
43.
Zurück zum Zitat Nathan S, Ghotra AS, Rajagopal K et al (2020) Left ventricular assist device outflow graft obstruction: a case series. ASAIO J 66(6):657–662PubMedCrossRef Nathan S, Ghotra AS, Rajagopal K et al (2020) Left ventricular assist device outflow graft obstruction: a case series. ASAIO J 66(6):657–662PubMedCrossRef
45.
Zurück zum Zitat Mehra MR, Salerno C, Naka Y et al (2018) A tale of the twist in the outflow graft: an analysis from the MOMENTUM 3 trial. J Heart Lung Transplant 37(11):1281–1284PubMedCrossRef Mehra MR, Salerno C, Naka Y et al (2018) A tale of the twist in the outflow graft: an analysis from the MOMENTUM 3 trial. J Heart Lung Transplant 37(11):1281–1284PubMedCrossRef
46.
Zurück zum Zitat Potapov EV, Netuka I, Kaufmann F et al (2018) Strategy for surgical correction and mitigation of outflow graft twist with a centrifugal-flow left ventricular assist system. J Heart Lung Transplant 37(5):670–673PubMedCrossRef Potapov EV, Netuka I, Kaufmann F et al (2018) Strategy for surgical correction and mitigation of outflow graft twist with a centrifugal-flow left ventricular assist system. J Heart Lung Transplant 37(5):670–673PubMedCrossRef
47.
Zurück zum Zitat Asawaeer M, Kadir S, Albulushi A et al (2020) Left ventricular assist device outflow cannula obstruction: importance of multimodality imaging. JACC Case Rep 2(10):1454–1456PubMedPubMedCentralCrossRef Asawaeer M, Kadir S, Albulushi A et al (2020) Left ventricular assist device outflow cannula obstruction: importance of multimodality imaging. JACC Case Rep 2(10):1454–1456PubMedPubMedCentralCrossRef
48.
Zurück zum Zitat Imamura T, Narang N, Kim G et al (2021) Impact of worsening of aortic insufficiency during HeartMate 3 LVAD support. Artif Organs 45(3):297–302PubMedCrossRef Imamura T, Narang N, Kim G et al (2021) Impact of worsening of aortic insufficiency during HeartMate 3 LVAD support. Artif Organs 45(3):297–302PubMedCrossRef
49.
Zurück zum Zitat Naganuma M, Akiyama M, Sasaki K et al (2021) Aortic insufficiency causes symptomatic heart failure during left ventricular assist device support. Tohoku J Exp Med 255(3):229–237PubMedCrossRef Naganuma M, Akiyama M, Sasaki K et al (2021) Aortic insufficiency causes symptomatic heart failure during left ventricular assist device support. Tohoku J Exp Med 255(3):229–237PubMedCrossRef
50.
Zurück zum Zitat Gonuguntla K, Patil S, Gadela NV et al (2020) Trends, outcomes, and predictors of sepsis and severe sepsis in patients with left ventricular assist devices. Cureus 12(4):e7523PubMedPubMedCentral Gonuguntla K, Patil S, Gadela NV et al (2020) Trends, outcomes, and predictors of sepsis and severe sepsis in patients with left ventricular assist devices. Cureus 12(4):e7523PubMedPubMedCentral
51.
Zurück zum Zitat Slaughter MS, Schlöglhofer T, Rich JD et al (2021) A power tracking algorithm for early detection of centrifugal flow pump thrombosis. ASAIO J 67(9):1018–1025PubMedPubMedCentralCrossRef Slaughter MS, Schlöglhofer T, Rich JD et al (2021) A power tracking algorithm for early detection of centrifugal flow pump thrombosis. ASAIO J 67(9):1018–1025PubMedPubMedCentralCrossRef
52.
Zurück zum Zitat Whitehouse KR, Avula D, Kahlon T et al (2022) Apixaban: alternative anticoagulation for heartmate 3 ventricular assist device. ASAIO J 68(3):318–322PubMedCrossRef Whitehouse KR, Avula D, Kahlon T et al (2022) Apixaban: alternative anticoagulation for heartmate 3 ventricular assist device. ASAIO J 68(3):318–322PubMedCrossRef
53.
Zurück zum Zitat Terrovitis JV, Ntalianis A, Kapelios CJ et al (2015) Dabigatran etexilate as second-line therapy in patients with a left ventricular assist device. Hellenic J Cardiol 56(1):20–25PubMed Terrovitis JV, Ntalianis A, Kapelios CJ et al (2015) Dabigatran etexilate as second-line therapy in patients with a left ventricular assist device. Hellenic J Cardiol 56(1):20–25PubMed
54.
Zurück zum Zitat Parikh VY, Parikh UM, Moctezuma-Ramirez A et al (2020) Factor Xa inhibitors in patients with continuous-flow left ventricular assist devices. Gen Thorac Cardiovasc Surg 68(11):1278–1284PubMedCrossRef Parikh VY, Parikh UM, Moctezuma-Ramirez A et al (2020) Factor Xa inhibitors in patients with continuous-flow left ventricular assist devices. Gen Thorac Cardiovasc Surg 68(11):1278–1284PubMedCrossRef
55.
Zurück zum Zitat Carroll AH, Ramirez MP, Dowlati E et al (2021) Management of intracranial hemorrhage in patients with a left ventricular assist device: a systematic review and meta-analysis. J Stroke Cerebrovasc Dis 30(2):105501PubMedCrossRef Carroll AH, Ramirez MP, Dowlati E et al (2021) Management of intracranial hemorrhage in patients with a left ventricular assist device: a systematic review and meta-analysis. J Stroke Cerebrovasc Dis 30(2):105501PubMedCrossRef
56.
Zurück zum Zitat Loyaga-Rendon RY, Kazui T, Acharya D (2021) Antiplatelet and anticoagulation strategies for left ventricular assist devices. Ann Transl Med 9(6):521PubMedPubMedCentralCrossRef Loyaga-Rendon RY, Kazui T, Acharya D (2021) Antiplatelet and anticoagulation strategies for left ventricular assist devices. Ann Transl Med 9(6):521PubMedPubMedCentralCrossRef
57.
Zurück zum Zitat Boswell MR, Stulak JM, Tchantchaleishvili V et al (2021) Intraoperative prothrombin complex concentrate administration and outcomes in patients undergoing left ventricular assist device implantation. Artif Organs 45(8):E223–E303PubMedCrossRef Boswell MR, Stulak JM, Tchantchaleishvili V et al (2021) Intraoperative prothrombin complex concentrate administration and outcomes in patients undergoing left ventricular assist device implantation. Artif Organs 45(8):E223–E303PubMedCrossRef
58.
Zurück zum Zitat Baumann Kreuziger L, Karkouti K, Tweddell J et al (2018) Antithrombotic therapy management of adult and pediatric cardiac surgery patients. J Thromb Haemost 16(11):2133–2146PubMedCrossRef Baumann Kreuziger L, Karkouti K, Tweddell J et al (2018) Antithrombotic therapy management of adult and pediatric cardiac surgery patients. J Thromb Haemost 16(11):2133–2146PubMedCrossRef
59.
Zurück zum Zitat Meyer AL, Malehsa D, Budde U et al (2014) Acquired von Willebrand syndrome in patients with a centrifugal or axial continuous flow left ventricular assist device. JACC Heart Fail 2(2):141–145PubMedCrossRef Meyer AL, Malehsa D, Budde U et al (2014) Acquired von Willebrand syndrome in patients with a centrifugal or axial continuous flow left ventricular assist device. JACC Heart Fail 2(2):141–145PubMedCrossRef
60.
Zurück zum Zitat Meyer AL, Malehsa D, Bara C et al (2010) Acquired von Willebrand syndrome in patients with an axial flow left ventricular assist device. Circ Heart Fail 3(6):675–681PubMedCrossRef Meyer AL, Malehsa D, Bara C et al (2010) Acquired von Willebrand syndrome in patients with an axial flow left ventricular assist device. Circ Heart Fail 3(6):675–681PubMedCrossRef
61.
Zurück zum Zitat Bartoli CR, Zhang D, Kang J et al (2018) Clinical and in vitro evidence that subclinical hemolysis contributes to LVAD thrombosis. Ann Thorac Surg 105(3):807–814PubMedCrossRef Bartoli CR, Zhang D, Kang J et al (2018) Clinical and in vitro evidence that subclinical hemolysis contributes to LVAD thrombosis. Ann Thorac Surg 105(3):807–814PubMedCrossRef
62.
Zurück zum Zitat Ravichandran AK, Parker J, Novak E et al (2014) Hemolysis in left ventricular assist device: a retrospective analysis of outcomes. J Heart Lung Transplant 33(1):44–50PubMedCrossRef Ravichandran AK, Parker J, Novak E et al (2014) Hemolysis in left ventricular assist device: a retrospective analysis of outcomes. J Heart Lung Transplant 33(1):44–50PubMedCrossRef
63.
Zurück zum Zitat Wert L, Hanke JS, Dogan G et al (2018) Argatroban administration as therapy for thrombosis in patients with continuous-flow ventricular assist devices. J Thorac Dis 10(Suppl 15):S1720–S1727PubMedPubMedCentralCrossRef Wert L, Hanke JS, Dogan G et al (2018) Argatroban administration as therapy for thrombosis in patients with continuous-flow ventricular assist devices. J Thorac Dis 10(Suppl 15):S1720–S1727PubMedPubMedCentralCrossRef
64.
Zurück zum Zitat Hanke JS, Dogan G, Wert L (2018) Left ventricular assist device exchange for the treatment of HeartMate II pump thrombosis. J Thorac Dis 10(Suppl 15):S1728–S1736PubMedPubMedCentralCrossRef Hanke JS, Dogan G, Wert L (2018) Left ventricular assist device exchange for the treatment of HeartMate II pump thrombosis. J Thorac Dis 10(Suppl 15):S1728–S1736PubMedPubMedCentralCrossRef
65.
Zurück zum Zitat Naber CK, Al-Nawas B, Baumgartner H et al (2007) Prophylaxe der infektiösen Endokarditis. Kardiologe 1:243–250CrossRef Naber CK, Al-Nawas B, Baumgartner H et al (2007) Prophylaxe der infektiösen Endokarditis. Kardiologe 1:243–250CrossRef
66.
Zurück zum Zitat Cho SM, Lee T, Starling RC et al (2019) The impact of infection and elevated INR in LVAD-associated Intracranial hemorrhage: a case-crossover study. ASAIO J 65(6):545–549PubMedCrossRef Cho SM, Lee T, Starling RC et al (2019) The impact of infection and elevated INR in LVAD-associated Intracranial hemorrhage: a case-crossover study. ASAIO J 65(6):545–549PubMedCrossRef
67.
Zurück zum Zitat Koken ZO, Yalcin YC, van Netten D et al (2021) Driveline exit-site care protocols in patients with left ventricular assist devices: a systematic review. Eur J Cardiothorac Surg 60(3):506–515PubMedPubMedCentralCrossRef Koken ZO, Yalcin YC, van Netten D et al (2021) Driveline exit-site care protocols in patients with left ventricular assist devices: a systematic review. Eur J Cardiothorac Surg 60(3):506–515PubMedPubMedCentralCrossRef
68.
Zurück zum Zitat Bernhardt AM, Schlöglhofer T, Lauenroth V et al (2020) Prevention and early treatment of driveline infections in ventricular assist device patients—The DESTINE staging proposal and the first standard of care protocol. J Crit Care 56:106–112PubMedCrossRef Bernhardt AM, Schlöglhofer T, Lauenroth V et al (2020) Prevention and early treatment of driveline infections in ventricular assist device patients—The DESTINE staging proposal and the first standard of care protocol. J Crit Care 56:106–112PubMedCrossRef
69.
Zurück zum Zitat Gustafsson F, Avraham BB, Chioncel O et al (2021) HFA of the ESC position paper on the management of LVAD-supported patients for the non-LVAD specialist healthcare provider Part 3: at the hospital and discharge. ESC Heart Fail 8(6):4425–4443PubMedPubMedCentralCrossRef Gustafsson F, Avraham BB, Chioncel O et al (2021) HFA of the ESC position paper on the management of LVAD-supported patients for the non-LVAD specialist healthcare provider Part 3: at the hospital and discharge. ESC Heart Fail 8(6):4425–4443PubMedPubMedCentralCrossRef
70.
Zurück zum Zitat Gurvits GE, Fradkov E (2017) Bleeding with the artificial heart: gastrointestinal hemorrhage in CF-LVAD patients. World J Gastroenterol 23(22):3945–3953PubMedPubMedCentralCrossRef Gurvits GE, Fradkov E (2017) Bleeding with the artificial heart: gastrointestinal hemorrhage in CF-LVAD patients. World J Gastroenterol 23(22):3945–3953PubMedPubMedCentralCrossRef
71.
Zurück zum Zitat Goldstein DJ, Naka Y, Horstmanshof D et al (2020) Association of clinical outcomes with left ventricular assist device use by bridge to transplant or destination therapy intent: the multicenter study of maglev technology in patients undergoing mechanical circulatory support therapy with heartmate 3 (MOMENTUM 3) randomized clinical trial. JAMA Cardiol 5(4):411–419PubMedPubMedCentralCrossRef Goldstein DJ, Naka Y, Horstmanshof D et al (2020) Association of clinical outcomes with left ventricular assist device use by bridge to transplant or destination therapy intent: the multicenter study of maglev technology in patients undergoing mechanical circulatory support therapy with heartmate 3 (MOMENTUM 3) randomized clinical trial. JAMA Cardiol 5(4):411–419PubMedPubMedCentralCrossRef
72.
Zurück zum Zitat Malik S, Malik SA, Ulmer LL et al (2019) Gastrointestinal bleeding with left ventricular assist devices (LVAD): locating the leak and identifying outcomes. J Clin Gastroenterol 53(5):e202–e207PubMedCrossRef Malik S, Malik SA, Ulmer LL et al (2019) Gastrointestinal bleeding with left ventricular assist devices (LVAD): locating the leak and identifying outcomes. J Clin Gastroenterol 53(5):e202–e207PubMedCrossRef
73.
Zurück zum Zitat Giede-Jeppe A, Roeder SS, Macha K et al (2020) Management of stroke in patients with left ventricular assist devices. J Stroke Cerebrovasc Dis 29(11):105166PubMedCrossRef Giede-Jeppe A, Roeder SS, Macha K et al (2020) Management of stroke in patients with left ventricular assist devices. J Stroke Cerebrovasc Dis 29(11):105166PubMedCrossRef
74.
Zurück zum Zitat Tenge T, Santer D, Schlieper D et al (2022) Inpatient specialist palliative care in patients with left ventricular assist devices (LVAD): a retrospective case series. Front Cardiovasc Med 9:879378PubMedPubMedCentralCrossRef Tenge T, Santer D, Schlieper D et al (2022) Inpatient specialist palliative care in patients with left ventricular assist devices (LVAD): a retrospective case series. Front Cardiovasc Med 9:879378PubMedPubMedCentralCrossRef
75.
Zurück zum Zitat Tenge T, Schlieper D, Schallenburger M et al (2021) „Palliative care“ bei Patienten mit Linksherzunterstützungssystem: systematische Übersichtsarbeit [Palliative care in patients with left ventricular assist devices: systematic review. Anaesthesist 70(12):1044–1050PubMedPubMedCentralCrossRef Tenge T, Schlieper D, Schallenburger M et al (2021) „Palliative care“ bei Patienten mit Linksherzunterstützungssystem: systematische Übersichtsarbeit [Palliative care in patients with left ventricular assist devices: systematic review. Anaesthesist 70(12):1044–1050PubMedPubMedCentralCrossRef
76.
Zurück zum Zitat Helman DN, Oz MC (2001) Developing a comprehensive mechanical support program. J Card Surg 16(3):203–208PubMedCrossRef Helman DN, Oz MC (2001) Developing a comprehensive mechanical support program. J Card Surg 16(3):203–208PubMedCrossRef
77.
Zurück zum Zitat Garg S, Ayers CR, Fitzsimmons C et al (2014) In-hospital cardiopulmonary arrests in patients with left ventricular assist devices. J Card Fail 20(12):899–904PubMedCrossRef Garg S, Ayers CR, Fitzsimmons C et al (2014) In-hospital cardiopulmonary arrests in patients with left ventricular assist devices. J Card Fail 20(12):899–904PubMedCrossRef
78.
Zurück zum Zitat Schlöglhofer T, Horvat J, Moscato F, Hartner Z, Necid G, Schwingenschlögl H, Riebandt J, Dimitrov K, Angleitner P, Wiedemann D, Laufer G, Zimpfer D, Schima H (2018) A standardized telephone intervention algorithm improves the survival of ventricular assist device outpatients. Artif Organs 42(10):961–969PubMedPubMedCentralCrossRef Schlöglhofer T, Horvat J, Moscato F, Hartner Z, Necid G, Schwingenschlögl H, Riebandt J, Dimitrov K, Angleitner P, Wiedemann D, Laufer G, Zimpfer D, Schima H (2018) A standardized telephone intervention algorithm improves the survival of ventricular assist device outpatients. Artif Organs 42(10):961–969PubMedPubMedCentralCrossRef
79.
Zurück zum Zitat Hamed S, Schmack B, Mueller F, Ehlermann P, Hittmann D, Ruhparwar A, Katus HA, Raake PW, Kreusser MM (2019) Implementation of an intensified outpatient follow-up protocol improves outcomes in patients with ventricular assist devices. Clin Res Cardiol 108(11):1197–1207PubMedCrossRef Hamed S, Schmack B, Mueller F, Ehlermann P, Hittmann D, Ruhparwar A, Katus HA, Raake PW, Kreusser MM (2019) Implementation of an intensified outpatient follow-up protocol improves outcomes in patients with ventricular assist devices. Clin Res Cardiol 108(11):1197–1207PubMedCrossRef
Metadaten
Titel
Der Patient am linksventrikulären Assist Device
Spezielle Aspekte der medizinischen Versorgung außerhalb der Herzchirurgie
verfasst von
PD Dr. Jasmin S. Hanke
Dr. Ali Saad Merzah
Jashar Arfai
Prof. Dr. Axel Haverich
Prof. Dr. Jan D. Schmitto
Dr. Günes Dogan
Publikationsdatum
24.03.2023

Weitere Artikel der Ausgabe 2/2023

Zeitschrift für Herz-,Thorax- und Gefäßchirurgie 2/2023 Zur Ausgabe