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Pediatric Cardiology

Erschienen in:

01.04.2010 | Riley Symposium

Hey bHLH Factors in Cardiovascular Development

verfasst von: Cornelia Wiese, Julia Heisig, Manfred Gessler

Erschienen in: Pediatric Cardiology | Ausgabe 3/2010

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Abstract

The Notch pathway is now firmly established as a key signaling system for embryonic cardiovascular development as well as some adult pathologies in vertebrates. We have identified Hey bHLH transcriptional repressors as critical, but partly redundant transducers of these signals. Hey proteins control cardiomyocyte differentiation, epithelial to mesenchymal transition of endocardial cells, and a number of key features of arterial endothelial cells with corresponding defects in knockout mice. While most of the phenotypes are described in embryonic development, there is increasing evidence for additional adult pathologies. Despite the functional importance of Hey proteins little is still known about their molecular targets and interactions.

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Titel: Hey bHLH Factors in Cardiovascular Development
verfasst von: Cornelia Wiese
Julia Heisig
Manfred Gessler
Publikationsdatum: 01.04.2010
Verlag: Springer-Verlag
Erschienen in: Pediatric Cardiology / Ausgabe 3/2010
Print ISSN: 0172-0643
Elektronische ISSN: 1432-1971
DOI: https://doi.org/10.1007/s00246-009-9609-9

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