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01.08.2011 | Research | Ausgabe 4/2011 Open Access

Critical Care 4/2011

High central venous oxygen saturation in the latter stages of septic shock is associated with increased mortality

Critical Care > Ausgabe 4/2011
Julien Textoris, Louis Fouché, Sandrine Wiramus, François Antonini, Sowita Tho, Claude Martin, Marc Leone
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​cc10325) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

All the authors contributed to the elaboration of this manuscript. LF and ST performed data extraction and wrote the manuscript draft. JT and SW performed data management and wrote the manuscript. FA performed data management and statistical analysis, while CM and ML did the study conception and wrote the manuscript. All authors read and approved the final version of the manuscript.



Current guidelines recommend maintaining central venous oxygen saturation (ScvO2) higher than 70% in patients with severe sepsis and septic shock. As high levels of ScvO2 may reflect an inadequate use of oxygen, our aim was to evaluate the relation between maximal ScvO2 levels (ScvO2max) and survival among intensive care unit (ICU) patients with septic shock.


We retrospectively analyzed data from all admissions to our ICU between January 2008 and December 2009. All septic shock patients in whom the ScvO2 was measured were included. The measures of ScvO2maxwithin the first 72 hours after the onset of shock were collected.


A total of 1,976 patients were screened and 152 (7.7%) patients met the inclusion criteria. The level of ScvO2maxwas 85% (78 to 89) in the non-survivors, compared with 79% (72 to 87) in the survivors (P = 0.009).


Our findings raise concerns about high levels of ScvO2 in patients with septic shock. This may reflect the severity of the shock with an impaired oxygen use. Future strategies may target an optimization of tissue perfusion in this specific subgroup of patients.
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