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Erschienen in: Journal of Cancer Research and Clinical Oncology 1/2020

01.01.2020 | Original Article – Cancer Research

High density of CD66b in primary high-grade ovarian cancer independently predicts response to chemotherapy

verfasst von: Alberto Posabella, Philipp Köhn, Alexandros Lalos, Alexander Wilhelm, Robert Mechera, Savas Soysal, Simone Muenst, Uwe Güth, Sylvia Stadlmann, Luigi Terracciano, Raoul A. Droeser, Jasmin Zeindler, Gad Singer

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 1/2020

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Abstract

Purpose

Ovarian carcinoma (OC) is the most lethal female genital cancer. After a primary curative surgical approach followed by chemotherapy, a fraction of the patients recur with chemoresistant disease. Data indicate a favorable therapeutic effect of tumor-infiltrating neutrophils (TIN) in OC. Our aim was to investigate the prognostic role of CD66b expression, corresponding to neutrophilic infiltration for recurrence-free survival (RFS) and overall survival (OS) in patients with OC.

Methods

A collective of 47 primary serous ovarian carcinoma and their matching recurrences were processed and stained with CD66b using immunohistochemistry. Tumors from patients with RFS of more than 6 months were defined as chemosensitive. Statistical analysis of CD66b expression was performed to assess the clinical endpoints.

Results

High density of CD66b expressing neutrophils in primary carcinoma was associated with chemosensitivity (p = 0.014) and longer RFS (p = 0.001). Univariate analysis identified high density of CD66b expressing neutrophils as a predictor for favorable RFS (HR 0.41, 95% CI 0.22–0.76, p < 0.005). Residual disease > 2 cm (HR 3.67, 95% CI 1.62–8.31, p < 0.002) and higher number of chemotherapy cycles (HR 1.28, 95% CI 1.05–1.55, p < 0.013) were associated with worse RFS. Multivariate analysis showed that high density of CD66b expressing neutrophils (HR 0.22, 95% CI 0.10–0.48, p < 0.001) and residual disease > 2 cm (HR 3.69, 95% CI 1.43–9.53, p < 0.007) were independent predictors of RFS but had no impact on OS.

Conclusion

High CD66b neutrophil density in primary high-grade OC predicts good response to initial chemotherapy and longer recurrence-free survival independent of known risk factors.
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Metadaten
Titel
High density of CD66b in primary high-grade ovarian cancer independently predicts response to chemotherapy
verfasst von
Alberto Posabella
Philipp Köhn
Alexandros Lalos
Alexander Wilhelm
Robert Mechera
Savas Soysal
Simone Muenst
Uwe Güth
Sylvia Stadlmann
Luigi Terracciano
Raoul A. Droeser
Jasmin Zeindler
Gad Singer
Publikationsdatum
01.01.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
Journal of Cancer Research and Clinical Oncology / Ausgabe 1/2020
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-019-03108-6

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