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Glycated hemoglobin (A1c) and glycated albumin (GA) are often used as indicators of glycemic control. In this study, we determined whether prednisolone (PSL) administration lowers plasma GA.
We investigated the factors affecting GA using multivariate analysis in 48 subjects with connective tissue diseases (CTDs).
Multiple regression analysis of GA showed that the dose of PSL [β = − 1.36; 95% confidence interval (CI) − 2.59 to − 0.14; p = 0.03], age (β = 0.06; 95% CI 0.03–0.09; p < 0.001), body mass index (BMI) (β = − 0.14; 95% CI − 0.28 to − 0.01; p = 0.042), and A1c (β = 1.4; 95% CI 0.38–2.42; p = 0.008) significantly correlated with GA (adjusted R2 = 0.518). Moreover, GA levels adjusted for age, sex, BMI, plasma albumin (Alb) and creatinine (Cre), and A1c in the subjects taking ≥ 5 mg PSL was significantly lower than those in those taking < 5 mg PSL. Finally, the dose of PSL (as a continuous variable) was negatively correlated with GA adjusted for age, sex, BMI, Alb, Cre, and A1c.
High dose (≥ 5 mg) PSL reduces GA concentration more than glycemia.
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- High Dose Prednisolone Lowers Plasma Glycated Albumin Levels Compared to Actual Glycemic Control: A Retrospective Observational Study
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