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Erschienen in: Strahlentherapie und Onkologie 9/2017

16.06.2017 | Review Article

High-dose-rate brachytherapy as salvage modality for locally recurrent prostate cancer after definitive radiotherapy

A systematic review

verfasst von: Georgios Chatzikonstantinou, Nikolaos Zamboglou, Claus Rödel, Eleni Zoga, Iosif Strouthos, Saeed Ahmed Butt, Nikolaos Tselis

Erschienen in: Strahlentherapie und Onkologie | Ausgabe 9/2017

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Abstract

Purpose

To review the current status of interstitial high-dose-rate brachytherapy as a salvage modality (sHDR BRT) for locally recurrent prostate cancer after definitive radiotherapy (RT).

Materials and methods

A literature search was performed in PubMed using “high-dose-rate, brachytherapy, prostate cancer, salvage” as search terms. In all, 51 search results published between 2000 and 2016 were identified. Data tables were generated and summary descriptions created. The main outcome parameters used were biochemical control (BC) and toxicity scores.

Results

Eleven publications reported clinical outcome and toxicity with follow-up ranging from 4–191 months. A variety of dose and fractionation schedules were described, including 19.0 Gy in 2 fractions up to 42.0 Gy in 6 fractions. The 5‑year BC ranged from 18–77%. Late grade 3 genitourinary and gastrointestinal toxicity was 0–32% and 0–5.1%, respectively.

Conclusions

sHDR BRT appears as safe and effective salvage modality for the reirradiation of locally recurrent prostate cancer after definitive RT.
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Metadaten
Titel
High-dose-rate brachytherapy as salvage modality for locally recurrent prostate cancer after definitive radiotherapy
A systematic review
verfasst von
Georgios Chatzikonstantinou
Nikolaos Zamboglou
Claus Rödel
Eleni Zoga
Iosif Strouthos
Saeed Ahmed Butt
Nikolaos Tselis
Publikationsdatum
16.06.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
Strahlentherapie und Onkologie / Ausgabe 9/2017
Print ISSN: 0179-7158
Elektronische ISSN: 1439-099X
DOI
https://doi.org/10.1007/s00066-017-1157-2

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