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01.12.2012 | Research | Ausgabe 1/2012 Open Access

World Journal of Surgical Oncology 1/2012

High expression of CXCR4, CXCR7 and SDF-1 predicts poor survival in renal cell carcinoma

Zeitschrift:
World Journal of Surgical Oncology > Ausgabe 1/2012
Autoren:
Linhui Wang, Wei Chen, Li Gao, Qing Yang, Bing Liu, Zhenjie Wu, Yang Wang, Yinghao Sun
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1477-7819-10-212) contains supplementary material, which is available to authorized users.
Linhui Wang, Wei Chen, Li Gao contributed equally to this work.

Competing interests

The authors declare that they have no competing interest.

Authors’ contributions

LHW participated in the design of the study and performed the statistical analysis. WC carried out the data collection and drafted the manuscript. LG participated in the construction of the tissue microarray and immunoassays. QY and BL carried out the follow-up. ZJW participated in the analysis of experimental results. YW carried out the immunoassays. YHS conceived of the study, participated in its design and coordination, and helped to draft the manuscript. All authors read and approved the final manuscript.

Abstract

Background

Chemokines and their receptors are known to play important roles in the tumorigenesis of many malignancies. The aim of this study was to evaluate the prognostic impact of the expression of the chemokine SDF-1 and its receptors CXCR4 and CXCR7 in patients with renal cell carcinoma.

Methods

The expression of CXCR4, CXCR7 and SDF-1 in specimens from 97 renal cell carcinoma patients was evaluated by immunohistochemistry on a tissue microarray. These results were correlated with the clinicopathological parameters and survival of the patients.

Results

CXCR4 and CXCR7 were expressed in all patients, whereas SDF-1 was expressed in 61 patients (62.9%). No association was observed between the expression of CXCR4, CXCR7 or SDF-1 and the clinical or pathological data except between SDF-1 expression and Fuhrman’s grade (P = 0.015). Patients with high expression of CXCR4, CXCR7 and SDF-1 had shorter overall survival and recurrence-free survival than those with low expression. In a multivariate analysis, the high expression of CXCR4, CXCR7 and SDF-1 correlated with poor overall survival and recurrence-free survival independent of gender, age, AJCC stage, lymph node status, metastasis, histologic variant and Fuhrman’s grade.

Conclusions

High levels of CXCR4, CXCR7 and SDF-1 were associated with poor overall survival and recurrence-free survival in renal cell carcinoma patients. CXCR4, CXCR7 and SDF-1 may serve as useful prognostic markers and therapeutic targets for renal cell carcinoma.
Zusatzmaterial
Authors’ original file for figure 1
12957_2012_1141_MOESM1_ESM.tiff
Authors’ original file for figure 2
12957_2012_1141_MOESM2_ESM.tiff
Literatur
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