Skip to main content

01.12.2018 | Letter | Ausgabe 1/2018 Open Access

Critical Care 1/2018

High-frequency percussive ventilation in acute respiratory distress syndrome: knocking at the door but can it be let in?

Critical Care > Ausgabe 1/2018
Herbert Spapen, Jouke De Regt, Viola van Gorp, Patrick M. Honoré
Wichtige Hinweise
This comment refers to the article available at: https://​doi.​org/​10.​1186/​s13054-017-1924-6.
Acute respiratory distress syndrome
High-frequency percussive ventilation
Positive end-expiratory pressure
High-frequency ventilation has been proposed as an alternative ventilation mode for acute respiratory distress syndrome (ARDS). Most experience was gained with high-frequency oscillation but this technique became abandoned due to unwarranted side effects (higher need for sedation and neuromuscular blockade, prolonged hemodynamic instability) and a higher mortality [ 1].
Godet et al. [ 2] recently documented the effects of short-term application of high-frequency percussive ventilation (HFPV) in animals and patients with early nonfocal moderate to severe ARDS. HFPV highly improved oxygenation and hemodynamics. In addition, HFPV allowed significant alveolar recruitment without concomitant hyperinflation of aerated lung regions [ 2]. Based on their observations, the authors suggested further investigation of HFPV on patient outcome during ARDS.
We have published the largest observational study to date on clinical use of HFPV in ARDS [ 3]. We retrospectively analyzed data from 42 patients (20 pneumonia-induced cases and 22 pneumonia-unrelated cases) with moderate to severe ARDS. HFPV was governed according to a predefined protocol and continued until patients could be switched to conventional ventilation. Essentially, our results corroborate the findings of Godet et al. [ 2]. Within 24 h, oxygenation improved to a similar proportion (i.e., doubling of the PaO 2/FiO 2 ratio). PaCO 2 was kept normal, barotrauma never occurred, and no significant hemodynamic changes were observed during the course of HFPV treatment. Moreover, the respiratory and hemodynamic benefits were sustained for at least 6 days after initiation of HFPV. Interestingly, less improved oxygenation, longer ventilation and ICU dependency, and higher 30-day mortality (50% vs 18%; P = 0.01) were observed in pneumonia-related ARDS. Most deaths in the pneumonia group were related to intractable multiorgan failure. Whether HFPV adversely propagates reactive pathways in pneumonia-related ARDS that ignite remote inflammation and sustain organ damage remains unknown.
According to Godet et al. [ 2], HFPV perfectly fits within the “Open the Lung and Keep it Open” concept of protective lung ventilation in ARDS. Applying HFPV, however, differs considerably from a low tidal volume/high positive end-expiratory pressure (PEEP) ventilation strategy where personalizing the PEEP level is primordial to minimize dynamic strain caused by alveolar recruitment/derecruitment [ 4]. Conventional HFPV settings may deliver injurious tidal volumes [ 5]. HFPV also significantly interferes with sedation protocols (e.g., low-level sedation, sedation breaks, etc.) and prone positioning, and requires supervision on a 24/7 basis by a dedicated team of trained physicians and respiratory therapists. Our clinical experience with HFPV does not support current introduction of this technique for ventilating ARDS patients.


Not applicable


No funding.

Availability of data and materials

Not applicable

Ethics approval and consent to participate

Not applicable

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://​creativecommons.​org/​licenses/​by/​4.​0/​), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://​creativecommons.​org/​publicdomain/​zero/​1.​0/​) applies to the data made available in this article, unless otherwise stated.
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2018

Critical Care 1/2018 Zur Ausgabe

Neu im Fachgebiet AINS

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update AINS und bleiben Sie gut informiert – ganz bequem per eMail.