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01.12.2012 | Original investigation | Ausgabe 1/2012 Open Access

Cardiovascular Diabetology 1/2012

High HbA1c levels correlate with reduced plaque regression during statin treatment in patients with stable coronary artery disease: Results of the coronary atherosclerosis study measuring effects of rosuvastatin using intravascular ultrasound in Japanese subjects (COSMOS)

Cardiovascular Diabetology > Ausgabe 1/2012
Hiroyuki Daida, Tadateru Takayama, Takafumi Hiro, Masakazu Yamagishi, Atsushi Hirayama, Satoshi Saito, Tetsu Yamaguchi, Masunori Matsuzaki, for the COSMOS Investigators
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1475-2840-11-87) contains supplementary material, which is available to authorized users.

Competing interests

H. Daida has received consulting fees and support for travel to meetings from AstraZeneca K.K. and Shionogi & Co., Ltd; acted as a consultant for GlaxoSmithKline K.K., Kowa Pharmaceutical Co., Ltd., Sanofi-Aventis K.K. and Schering-Plough Corp; received grants from Astellas Pharma Inc., AstraZeneca K.K., Bayer Yakuhun Ltd., Dainippon Sumitomo Pharma Co., Ltd., Kissei Pharmaceutical Co., Ltd., Kowa Pharmaceutical Co., Ltd., Kyowa Medex Co., Ltd., MSD K.K., Novartis Pharma K.K., Nippon Boehringer Ingelheim Co., Ltd., Otsuka Pharmaceutical Co., Ltd., Public Health Research Foundation, Roche Diagnostics K.K., Sanofi-Aventis K.K., Sanwa Kagaku Kenkyusho Co., Ltd., Schering-Plough Corp., Shionogi & Co., Ltd., Takeda Pharmaceutical Co., Ltd., and The Waksman Foundation of Japan, Inc.; and served on the speakers bureaus of Astellas Pharma Inc., Bayer Yakuhin Ltd., Dainippon Sumitomo Pharma Co., Ltd., Kissei Pharmaceutical Co., Ltd., Kowa Pharmaceutical Co., Ltd., MSD K.K., Novartis Pharma K.K., Nippon Boehringer Ingleheim Co., Ltd., Sanofi-Aventis K.K., Sanwa Kagaku Kenkyusho Co., Ltd., Schering-Plough Corp. and Takeda Pharmaceutical Co., Ltd. The other authors report no conflicts of interest.

Author contributions

HD drafted the manuscript; TT, TH and MY conceived of and designed the study; AY and SS contributed to the analysis of the data; TY collected data; and MM coordinated and managed the study. All authors read and approved the final manuscript.



The incidence of cardiac events is higher in patients with diabetes than in people without diabetes. The Coronary Atherosclerosis Study Measuring Effects of Rosuvastatin Using Intravascular Ultrasound in Japanese Subjects (COSMOS) demonstrated significant plaque regression in Japanese patients with chronic coronary disease after 76 weeks of rosuvastatin (2.5 mg once daily, up-titrated to a maximum of 20 mg/day to achieve LDL cholesterol <80 mg/dl).


In this subanalysis of COSMOS, we examined the association between HbA1c and plaque regression in 40 patients with HbA1c ≥6.5% (high group) and 86 patients with HbA1c <6.5% (low group).


In multivariate analyses, HbA1c and plaque volume at baseline were major determinants of plaque regression. LDL cholesterol decreased by 37% and 39% in the high and low groups, respectively, while HDL cholesterol increased by 16% and 22%, respectively. The reduction in plaque volume was significantly (p = 0.04) greater in the low group (from 71.0 ± 39.9 to 64.7 ± 34.7 mm3) than in the high group (from 74.3 ± 34.2 to 71.4 ± 32.3 mm3). Vessel volume increased in the high group but not in the low group (change from baseline: +4.2% vs −0.8%, p = 0.02). Change in plaque volume was significantly correlated with baseline HbA1c.


Despite similar improvements in lipid levels, plaque regression was less pronounced in patients with high HbA1c levels compared with those with low levels. Tight glucose control during statin therapy may enhance plaque regression in patients with stable coronary disease.

Trial registration, Identifier NCT00329160
Authors’ original file for figure 1
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