The online version of this article (doi:10.1186/2045-7022-4-32) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests. The sponsors, ThermoFisher Diagnostics provided the IgE testing, but had no involvement in the interpreting of data, writing the report or in the decision to submit the paper for publication.
AW - contributed to the study design, analysis and interpretation of data, drafted the manuscript and approved the final manuscript as submitted. ÅS, LH, CEW and MSP – all contributed to the analysis and interpretation of data, reviewed and revised the manuscript and approved the final manuscript as submitted. ER - is responsible for study conception and design, has contributed to the analysis and interpretation of data, reviewed and revised the manuscript and approved the final manuscript as submitted. All authors read and approved the final manuscript.
Few population-based cohort studies have examined reported food hypersensitivity longitudinally. We investigated prevalence, incidence and remission of perceived food hypersensitivity among schoolchildren from 8 to 12 years of age, and risk factors associated with incidence and remission.
A population-based cohort including all 7–8 year-old children in three Swedish towns was recruited in 2006. A total of 2,585 (96% of invited) children participated in a parental questionnaire. The children in two of the towns, n = 1,700 (90% of invited) also participated in skin-prick-testing with airborne allergens. The cohort was followed using the same methods at 11–12 years of age. At study follow up, specific IgE to foods was analyzed in a randomized subset of children (n = 652).
The prevalence of perceived food hypersensitivity increased from 21% at 8 years to 26% at 12 years of age. During this four-year-period, the cumulative incidence of food hypersensitivity was high (15%), as was remission (33%). This pattern was particularly evident for hypersensitivity to cow´s milk, while the incidence of hypersensitivity to other foods was lower. Female sex, allergic heredity, current rhinitis and allergic sensitization were associated with the incidence of food hypersensitivity and allergic sensitization was negatively associated with remission. Risk-factor-patterns for both incidence and remission were different for hypersensitivity to milk compared with hypersensitivity to other foods. Generally, the agreement between reported food hypersensitivity and IgE-sensitization to the implicated food was poor.
In this longitudinal, population-based cohort-study perceived food hypersensitivity was common among children between ages 8 and 12, often transient and not well correlated with food-specific IgE. While these findings suggest an overestimated prevalence of food hypersensitivity, the public-health-significance remains high as they reflect the perceived reality to which the children adapt their life and food intakes.
Additional file 1: The Olin Pediatric Questionnaire 2006. (DOC 200 KB)13601_2014_1065_MOESM1_ESM.doc
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Johansson SG, Bieber T, Dahl R, Friedmann PS, Lanier BQ, Lockey RF, Motala C, Ortega Martell JA, Platts-Mills TA, Ring J, Thien F, Van Cauwenberge P, Williams HC: Revised nomenclature for allergy for global use: report of the nomenclature review committee of the world allergy organization, October 2003. J Allergy Clin Immunol. 2004, 113: 832-836. 10.1016/j.jaci.2003.12.591. CrossRefPubMed
Östblom E, Lilja G, Pershagen G, van Hage M, Wickman M: Phenotypes of food hypersensitivity and development of allergic diseases during the first 8 years of life. Clin Exp All. 2008, 38: 1325-1332. 10.1111/j.1365-2222.2008.03010.x. CrossRef
Nwaru BI, Hickstein L, Panesar SS, Muraro A, Werfel T, Cardona V, Dubois AE, Halken S, Hoffmann-Sommergruber K, Poulsen LK, Roberts G, Van Ree R, Vlieg-Boerstra BJ, Sheikh A: The epidemiology of food allergy in Europe: a systematic review and meta-analysis. Allergy. 2014, 69 (1): 62-75. 10.1111/all.12305. CrossRefPubMed
Meyer R, De Koker C, Dziubak R, Venter C, Dominguez-Ortega G, Cutts R, Yerlett N, Skrapak AK, Fox AT, Shah N: Malnutrition in children with food allergies in the UK. J Hum Nutr Diet. 2012, 23 (4): 307-314.
Wilt TJ, Shaukat A, Shamliyan T, Taylor BC, MacDonald R, Tacklind J, Rutks I, Schwarzenberg SJ, Kane RL, Levitt M: Lactose intolerance and health. Evid Rep Technol Assess. 2010, 192: 1-410.
Liu AH, Jaramillo R, Sicherer SH, Wood RA, Bock SA, Burks AW, Massing M, Cohn RD, Zeldin DC: National prevalence and risk factors for food allergy and relationship to asthma: results from the National Health and Nutrition Examination Survey 2005–2006. J Allergy Clin Immunol. 2010, 126: 798-806. 10.1016/j.jaci.2010.07.026. PubMedCentralCrossRefPubMed
Patelis A, Gunnbjornsdottir M, Borres MP, Burney P, Gislason T, Toren K, Forsberg B, Alving K, Malinovschi A, Janson C: Natural history of perceived food hypersensitivity and IgE sensitisation to food allergens in a cohort of adults. PLoS One. 2014, 9 (1): e85333-10.1371/journal.pone.0085333. Epub 2014/01/16 PubMedCentralCrossRefPubMed
Soost S, Leynaert B, Almqvist C, Edenharter G, Zuberbier T, Worm M: Risk factors of adverse reactions to food in German adults. Clin Exp All. 2009, 39 (7): 1036-1044. 10.1111/j.1365-2222.2008.03184.x. CrossRef
Asher MI, Keil U, Anderson HR, Beasley R, Crane J, Martinez F, Mitchell EA, Pearce N, Sibbald B, Stewart AW, Strachan D, Weiland SK, Williams HC: International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. Eur Respir J. 1995, 8: 483-491. 10.1183/09031936.95.08030483. CrossRefPubMed
Rönmark E, Perzanowski M, Platts-Mills T, Lundbäck B: Four-year incidence of allergic sensitization among schoolchildren in a community where allergy to cat and dog dominates sensitization: report from the Obstructive Lung Disease in Northern Sweden Study Group. J Allergy Clin Immunol. 2003, 112: 747-754. 10.1016/S0091-6749(03)01866-9. CrossRefPubMed
Strinnholm A, Winberg A, West C, Hedman L, Rönmark E: Food hypersensitivity is common in Swedish schoolchildren, especially oral reactions to fruit and gastrointestinal reactions to milk. Acta Paediatr. 2014, Epub 2014/08/12
Ballardini N, Kull I, Lind T, Hallner E, Almqvist C, Östblom E, Melen E, Pershagen G, Lilja G, Bergström A, Wickman M: Development and comorbidity of eczema, asthma and rhinitis to age 12: data from the BAMSE birth cohort. Allergy. 2012, 67 (4): 537-544. 10.1111/j.1398-9995.2012.02786.x. CrossRefPubMed
Asarnoj A, Moverare R, Östblom E, Poorafshar M, Lilja G, Hedlin G, van Hage M, Ahlstedt S, Wickman M: IgE to peanut allergen components: relation to peanut symptoms and pollen sensitization in 8-year-olds. Allergy. 2010, 65 (9): 1189-1195. PubMed
Geroldinger-Simic M, Zelniker T, Aberer W, Ebner C, Egger C, Greiderer A, Prem N, Lidholm J, Ballmer-Weber BK, Vieths S, Bohle B: Birch pollen-related food allergy: clinical aspects and the role of allergen-specific IgE and IgG4 antibodies. J Allergy Clin Immunol. 2011, 127: 616-622. 10.1016/j.jaci.2010.10.027. CrossRefPubMed
- High incidence and remission of reported food hypersensitivity in Swedish children followed from 8 to 12 years of age – a population based cohort study
Christina E West
Matthew S Perzanowski
- BioMed Central
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