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01.12.2014 | Research | Ausgabe 1/2014 Open Access

Clinical and Translational Allergy 1/2014

High incidence and remission of reported food hypersensitivity in Swedish children followed from 8 to 12 years of age – a population based cohort study

Zeitschrift:
Clinical and Translational Allergy > Ausgabe 1/2014
Autoren:
Anna Winberg, Åsa Strinnholm, Linnea Hedman, Christina E West, Matthew S Perzanowski, Eva Rönmark
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​2045-7022-4-32) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests. The sponsors, ThermoFisher Diagnostics provided the IgE testing, but had no involvement in the interpreting of data, writing the report or in the decision to submit the paper for publication.

Authors’ contributions

AW - contributed to the study design, analysis and interpretation of data, drafted the manuscript and approved the final manuscript as submitted. ÅS, LH, CEW and MSP – all contributed to the analysis and interpretation of data, reviewed and revised the manuscript and approved the final manuscript as submitted. ER - is responsible for study conception and design, has contributed to the analysis and interpretation of data, reviewed and revised the manuscript and approved the final manuscript as submitted. All authors read and approved the final manuscript.

Abstract

Background

Few population-based cohort studies have examined reported food hypersensitivity longitudinally. We investigated prevalence, incidence and remission of perceived food hypersensitivity among schoolchildren from 8 to 12 years of age, and risk factors associated with incidence and remission.

Methods

A population-based cohort including all 7–8 year-old children in three Swedish towns was recruited in 2006. A total of 2,585 (96% of invited) children participated in a parental questionnaire. The children in two of the towns, n = 1,700 (90% of invited) also participated in skin-prick-testing with airborne allergens. The cohort was followed using the same methods at 11–12 years of age. At study follow up, specific IgE to foods was analyzed in a randomized subset of children (n = 652).

Results

The prevalence of perceived food hypersensitivity increased from 21% at 8 years to 26% at 12 years of age. During this four-year-period, the cumulative incidence of food hypersensitivity was high (15%), as was remission (33%). This pattern was particularly evident for hypersensitivity to cow´s milk, while the incidence of hypersensitivity to other foods was lower. Female sex, allergic heredity, current rhinitis and allergic sensitization were associated with the incidence of food hypersensitivity and allergic sensitization was negatively associated with remission. Risk-factor-patterns for both incidence and remission were different for hypersensitivity to milk compared with hypersensitivity to other foods. Generally, the agreement between reported food hypersensitivity and IgE-sensitization to the implicated food was poor.

Conclusions

In this longitudinal, population-based cohort-study perceived food hypersensitivity was common among children between ages 8 and 12, often transient and not well correlated with food-specific IgE. While these findings suggest an overestimated prevalence of food hypersensitivity, the public-health-significance remains high as they reflect the perceived reality to which the children adapt their life and food intakes.
Zusatzmaterial
Additional file 1: The Olin Pediatric Questionnaire 2006. (DOC 200 KB)
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Authors’ original file for figure 1
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Authors’ original file for figure 7
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Literatur
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