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Neuroscience Bulletin
Erschienen in:

04.06.2024 | Original Article

High Magnesium Promotes the Recovery of Binocular Vision from Amblyopia via TRPM7

verfasst von: Menghan Dai, Jie Li, Xiangwen Hao, Na Li, Mingfang Zheng, Miao He, Yu Gu

Erschienen in: Neuroscience Bulletin | Ausgabe 9/2024

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Abstract

Abnormal visual experience during the critical period can cause deficits in visual function, such as amblyopia. High magnesium (Mg2+) supplementary can restore ocular dominance (OD) plasticity, which promotes the recovery of amblyopic eye acuity in adults. However, it remains unsolved whether Mg2+ could recover binocular vision in amblyopic adults and what the molecular mechanism is for the recovery. We found that in addition to the recovery of OD plasticity, binocular integration can be restored under the treatment of high Mg2+ in amblyopic mice. Behaviorally, Mg2+-treated amblyopic mice showed better depth perception. Moreover, the effect of high Mg2+ can be suppressed with transient receptor potential melastatin-like 7 (TRPM7) knockdown. Collectively, our results demonstrate that high Mg2+ could restore binocular visual functions from amblyopia. TRPM7 is required for the restoration of plasticity in the visual cortex after high Mg2+ treatment, which can provide possible clinical applications for future research and treatment of amblyopia.
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Metadaten
Titel
High Magnesium Promotes the Recovery of Binocular Vision from Amblyopia via TRPM7
verfasst von
Menghan Dai
Jie Li
Xiangwen Hao
Na Li
Mingfang Zheng
Miao He
Yu Gu
Publikationsdatum
04.06.2024
Verlag
Springer Nature Singapore
Erschienen in
Neuroscience Bulletin / Ausgabe 9/2024
Print ISSN: 1673-7067
Elektronische ISSN: 1995-8218
DOI
https://doi.org/10.1007/s12264-024-01242-x

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