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28.09.2016 | Original Article | Ausgabe 11/2016

Tumor Biology 11/2016

High mucin-7 expression is an independent predictor of adverse clinical outcomes in patients with clear-cell renal cell carcinoma

Zeitschrift:
Tumor Biology > Ausgabe 11/2016
Autoren:
SonTung NguyenHoang, Yidong Liu, Le Xu, Yuan Chang, Lin Zhou, Zheng Liu, Zongming Lin, Jiejie Xu
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s13277-016-5375-5) contains supplementary material, which is available to authorized users.
SonTung NguyenHoang, Yidong Liu, and Le Xu contributed equally to this work.

Abstract

Mucin-7 is a member of the secreted mucins family. Mucins might play a crucial role during tumor development and its aberrant expression was observed in several types of tumor. Our study aims to evaluate the prognostic significance of Mucin-7 expression in postoperative clear-cell renal cell carcinoma (ccRCC) patients. In this retrospective study, we enrolled 392 patients with ccRCC undergoing nephrectomy between 2008 and 2009 in a single center. The median follow-up was 73 months (range 39–74 months). Mucin-7 expression was evaluated by immunohistochemistry protocol on ccRCC specimens. Kaplan-Meier survival analysis was conducted to compare survival curves. Univariate and multivariate Cox regression models were applied to assess the impact of prognostic factors in overall survival (OS) and recurrence-free survival (RFS). A nomogram was then constructed based on the independent prognosticators identified on multivariate analysis. The results displayed that Mucin-7 expression was significantly associated with tumor size (p = 0.034), pT stage (p = 0.004), TNM stage (p = 0.008), and necrosis (p = 0.043). Patients with high Mucin-7 expression had significant worse outcomes in both OS (p < 0.001) and RFS (p < 0.001) compared to those with low Mucin-7 expression. MUC7 expression was considered as an independent predictive factor for OS (HR 2.286; 95 %CI 1.167–4.475; p = 0.016) and RFS (HR 2.055; 95 %CI 1.086–3.887; p = 0.027). A nomogram integrating Mucin-7 expression and other independent prognosticators was constructed. In summary, the high Mucin-7 expression is a potential prognosticator of adverse clinical outcome in ccRCC patients after surgery.

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Table S1 (DOC 53 kb)
13277_2016_5375_MOESM1_ESM.doc
High Resolution (TIFF 10865 kb)
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High Resolution (TIFF 11173 kb)
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