Background
Methods
Study populations
Statistical analysis
Results
Patients | |
---|---|
No. | 139 |
Mean age (years, ± SD) | 58.4 ± 10.5 |
Gender (male/female) | 107/32 |
Stage (LD/ED) | 55/83 |
Smoking (never/ever) | 39/100 |
NLR | 3.13 (2.23–4.50) |
PLR | 132.7 (97.8–186.5) |
NLR values and clinical parameters
Variables | NLR ≤ 4.55 | NLR > 4.55 |
p value | ||
---|---|---|---|---|---|
n
|
n
| ||||
Age (years, ± SD) | 57.61 ± 10.63 | 107 | 60.81 ± 9.70 | 32 | 0.129 |
Gender (male/female) | 81/26 | 107 | 26/6 | 32 | 0.513 |
Stage (LD/ED) | 50/57 | 107 | 6/26 | 32 |
0.005**
|
Metastasis (yes/no) | 80/27 | 107 | 28/4 | 32 | 0.129 |
Brain metastasis (yes/no) | 7/100 | 107 | 2/30 | 32 | 1.000 |
Bone metastasis (yes/no) | 9/98 | 107 | 6/26 | 32 | 0.111 |
Liver metastasis (yes/no) | 11/96 | 107 | 9/23 | 32 |
0.020*
|
Adrenal metastasis (yes/no) | 10/97 | 107 | 4/28 | 32 | 0.738 |
Pleural metastasis (yes/no) | 7/100 | 107 | 5/27 | 32 | 0.147 |
Lymph node metastasis (yes/no) | 72/35 | 107 | 27/5 | 32 | 0.061 |
Mediastinal metastasis (yes/no) | 3/104 | 107 | 1/31 | 32 | 1.000 |
Smoking (never/ever) | 32/75 | 107 | 7/25 | 32 | 0.375 |
Smoking amount (BI) | 660 (380–970) | 73 | 860 (600–1200) | 25 |
0.031*
|
Family cancer history (yes/no) | 19/48 | 67 | 8/12 | 20 | 0.323 |
Exposure to cooking oil fume (never/ever) | 32/31 | 63 | 7/12 | 19 | 0.286 |
Operation (yes/no) | 12/95 | 107 | 2/30 | 32 | 0.413 |
Radiotherapy (yes/no) | 52/55 | 107 | 9/23 | 32 |
0.041*
|
Chemotherapy (yes/no) | 96/11 | 107 | 24/8 | 32 |
0.043*
|
PLR | 115 (89–165) | 107 | 221 (175–324) | 32 |
0.000***
|
RBC (1012/L) | 4.49 (4.17–4.88) | 107 | 4.18 (3.47–4.47) | 32 |
0.002**
|
Hb (g/L) | 135 (124–146) | 107 | 120 (106–134) | 32 |
0.001**
|
MCV (fL) | 91.4 (87.8–94.1) | 107 | 92.2 (87.6–93.8) | 32 | 0.906 |
PLT (109/L) | 181 (138–228) | 107 | 206 (169–289) | 32 |
0.035*
|
WBC (109/L) | 6.13 (5.07–7.23) | 107 | 7.34 (6.34–9.75) | 32 |
0.001**
|
Neutrophil (109/L) | 4.08 (3.00–4.98) | 107 | 5.62 (4.98–7.58) | 32 |
0.000***
|
Lymphocyte (109/L) | 1.46 (1.22–1.82) | 107 | 0.96 (0.71–1.10) | 32 |
0.000***
|
Alb (g/L) | 41.2 (38.6–43.6) | 104 | 37.1 (33.0–40.2) | 32 |
0.000***
|
LDH (U/L) | 193 (175–238) | 102 | 264 (205–360) | 31 |
0.001**
|
ALP (U/L) | 79 (65–95) | 104 | 82 (59–114) | 32 | 0.595 |
CHO (mmol/L) | 4.46 (4.06–4.90) | 102 | 3.87 (3.30–4.47) | 31 |
0.000***
|
TG (mmol/L) | 1.22 (0.88–1.45) | 102 | 1.06 (0.87–1.46) | 31 | 0.661 |
HDL-C (mmol/L) | 1.25 (1.08–1.54) | 102 | 1.09 (0.94–1.34) | 31 |
0.007**
|
LDL-C (mmol/L) | 2.63 (2.27–3.00) | 102 | 2.23 (1.63–2.72) | 31 |
0.001**
|
CR (μmol/L) | 76.1 (65.3–87.9) | 104 | 67.6 (55.4–83.7) | 32 | 0.082 |
CEA (ng/ml) | 3.71 (1.80–9.13) | 85 | 3.66 (2.04–10.25) | 29 | 0.747 |
CYFRA21-1 (ng/ml) | 3.10 (2.27–4.84) | 75 | 4.76 (2.78–7.43) | 26 |
0.017*
|
NSE (ng/ml) | 38.85 (22.86–97.62) | 86 | 71.29 (37.66–113.23) | 26 |
0.034*
|
PLR values and clinical parameters
Variables | PLR ≤ 148 | PLR > 148 |
p value | ||
---|---|---|---|---|---|
n
|
n
| ||||
Age (years, ±SD) | 58.54 ± 9.60 | 76 | 58.11 ± 11.52 | 63 | 0.811 |
Gender (male/female) | 60/16 | 76 | 47/16 | 63 | 0.552 |
Stage (LD/ED) | 43/33 | 76 | 13/50 | 63 |
0.000***
|
Metastasis (yes/no) | 56/20 | 76 | 52/11 | 63 | 0.212 |
Brain metastasis (yes/no) | 3/73 | 76 | 6/57 | 63 | 0.299 |
Bone metastasis (yes/no) | 4/72 | 76 | 11/52 | 63 | 0.021 |
Liver metastasis (yes/no) | 5/71 | 76 | 15/48 | 63 | 0.004 |
Adrenal metastasis (yes/no) | 6/70 | 76 | 8/55 | 63 | 0.349 |
Pleural metastasis (yes/no) | 4/72 | 76 | 8/55 | 63 | 0.120 |
Lymph node metastasis (yes/no) | 53/23 | 76 | 46/17 | 63 | 0.671 |
Mediastinal metastasis (yes/no) | 2/74 | 76 | 2/61 | 63 | 1.000 |
Smoking (never/ever) | 19/57 | 76 | 20/43 | 63 | 0.449 |
Smoking amount (BI) | 720 (400–980) | 55 | 680 (400–1200) | 43 | 0.725 |
Family cancer history (yes/no) | 16/31 | 47 | 11/29 | 40 | 0.511 |
Exposure to cooking fume (never/ever) | 27/19 | 46 | 12/24 | 36 |
0.022*
|
Operation (yes/no) | 11/65 | 76 | 3/60 | 63 | 0.058 |
Radiotherapy (yes/no) | 39/37 | 76 | 22/41 | 63 | 0.052 |
Chemotherapy (yes/no) | 71/5 | 76 | 49/14 | 63 |
0.008**
|
NLR | 2.59 (1.69–3.17) | 76 | 4.43 (2.88–5.50) | 63 |
0.000***
|
RBC (1012/L) | 4.57 (4.18–5.02) | 76 | 4.24 (3.74–4.57) | 63 |
0.000***
|
Hb (g/L) | 139 (126–149) | 76 | 124 (107–136) | 63 |
0.000***
|
MCV (fL) | 92.4 (89.1–95.7) | 76 | 90.1 (86.4–93.3) | 63 |
0.012*
|
PLT (109/L) | 155 (130–192) | 76 | 226 (192–299) | 63 |
0.000***
|
WBC (109/L) | 6.45 (5.29–7.81) | 76 | 6.52 (5.15–7.57) | 63 | 0.828 |
Neutrophil (109/L) | 4.11 (3.02–5.20) | 76 | 4.64 (3.59–5.76) | 63 | 0.075 |
Lymphocyte (109/L) | 1.63 (1.32–2.00) | 76 | 1.08 (0.87–1.29) | 63 |
0.000***
|
Alb (g/L) | 41.8 (39.5–44.2) | 75 | 38.2 (34.8–41.2) | 61 |
0.000***
|
LDH (U/L) | 196 (176–239) | 73 | 219 (183–290) | 60 |
0.023*
|
ALP (U/L) | 79 (66–93) | 75 | 78 (59–107) | 61 | 0.941 |
CHO (mmol/L) | 4.47 (4.09–4.96) | 73 | 4.15 (3.62–4.59) | 60 | 0.002** |
TG (mmol/L) | 1.27 (0.91–1.68) | 73 | 1.07 (0.82–1.43) | 60 | 0.115 |
HDL-C (mmol/L) | 1.24 (1.07–1.50) | 73 | 1.18 (0.98–1.49) | 60 | 0.144 |
LDL-C (mmol/L) | 2.65 (2.40–3.18) | 73 | 2.38 (2.08–2.82) | 60 |
0.003**
|
CR (μmol/L) | 76.9 (70.9–89.0) | 75 | 69.2 (59.0–83.6) | 61 |
0.011*
|
CEA (ng/ml) | 3.75 (1.90–8.21) | 60 | 3.61 (1.90–10.87) | 54 | 0.790 |
CYFRA21-1 (ng/ml) | 3.32 (2.33–4.94) | 51 | 3.35 (2.32–6.50) | 50 | 0.370 |
NSE (ng/ml) | 40.81 (19.22–82.20) | 60 | 48.65 (28.26–127.48) | 52 | 0.066 |
NLR, PLR and prognosis
Variables | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
HR (95% CI) |
p value | HR (95% CI) |
P value | |
NLR > 4.55 vs ≤4.55 | 3.309 (2.088–5.244) |
0.000***
| 2.093 (1.079–4.063) |
0.029*
|
PLR > 148 vs ≤148 | 1.813 (1.200–2.738) |
0.005**
| 0.332 | |
Stage ED vs LD | 3.282 (2.042–5.272) |
0.000***
| 2.692 (1.501–4.830) |
0.001**
|
Metastasis (yes/no) | 2.085 (1.178–3.691) |
0.012*
| 0.697 | |
Liver metastasis yes vs no | 3.377 (2.034–5.605) |
0.000***
| 2.427 (1.341–4.395) |
0.003**
|
Adrenal metastasis yes vs no | 2.270 (1.256–4.103) |
0.007**
| 0.398 | |
Radiotherapy yes vs no | 0.576 (0.375–0.884) |
0.012*
| 0.479 | |
Chemotherapy yes vs no | 0.455 (0.265–0.782) |
0.004**
| 0.098 | |
RBC normal vs low | 0.567 (0.370–0.869) |
0.009**
| 0.128 | |
Haemoglobin normal vs low | 0.528 (0.349–0.801) |
0.003**
| 0.608 | |
Albumin normal vs low | 0.493 (0.289–0.840) |
0.009**
| 0.101 | |
Lactate dehydrogenase high vs normal | 1.926 (1.259–2.947) |
0.003**
| 0.627 |