The authors declare that they have no competing interests.
VMZ participated in the design of the study and helped to draft the manuscript. GAGV participated in collecting data and carried out information analysis. GVO participated in collecting data and carried out information analysis. BGV participated in collecting data and carried out information analysis. CRR helped write main draft, performed the final information and statistical analysis. MMA helped to draft the manuscript and carried out information analysis. MAMA participated in collecting data and helped to draft the manuscript. AFH helped write main draft, performed the final information and statistical analysis. All the authors read and approved the final manuscript.
Primary hyperparathyroidism (PHPT) and metabolic syndrome (MS) have been independently related to cardiovascular morbidities, however this association is still controversial. Mexican population has a high prevalence of metabolic syndrome, however its frequency seems to be even higher than expected in patients with PHPT.
We retrospectively reviewed the charts of patients that underwent parathyroidectomy for PHPT in a referral center and used the criteria from the National Cholesterol Educational Program (NCEP)/Adult Treatment Panel III (ATP III) to define MS before surgery. We compared the characteristics between the patients with and without MS.
60 patients were analyzed, 77% were female and 72% had a single parathyroid adenoma. MS was present in 59% of the patients, this group was significantly older (57 vs. 48 years, p = 0.01) and they had lower iPTH (115 vs. 161 ng/ml, p = 0.017). Other parameters did not show differences.
MS is frequent in our population diagnosed with primary hyperparathyroidism, adverse cardiovascular parameters are common and significant differences in calcium metabolism compared to the non-MS group are present.
Adami S, Marcocci C, Gatti D. Epidemiology of primary hyperparathyroidism in Europe. J Bone Miner Res. 2002;17 Suppl 2:N18–23. PubMed
Nilsson IL, Yin L, Lundgren E, Rastad J, Ekbom A. Clinical presentation of primary hyperparathyroidism in Europe–nationwide cohort analysis on mortality from nonmalignant causes. J Bone Miner Res. 2002;17 Suppl 2:N68–74. PubMed
Han D, Trooskin S, Wang X. Prevalence of cardiovascular risk factors in male and female patients with primary hyperparathyroidism. J Endocrinol Invest. 2012;35(6):548–52. PubMed
Beltran-Sanchez H, Harhay MO, Harhay MM, McElligott S. Prevalence and trends of metabolic syndrome in the adult U.S. population 1999–2010. J Am College of Cardiology. 2013;62(8):697–703. CrossRef
Gao W. Does the constellation of risk factors with and without abdominal adiposity associate with different cardiovascular mortality risk? Int J Obes (Lond). 2008;32(5):757–62. CrossRef
Acuna-Alonzo V, Flores-Dorantes T, Kruit JK, Villarreal-Molina T, Arellano-Campos O, Hunemeier T, et al. A functional ABCA1 gene variant is associated with low HDL-cholesterol levels and shows evidence of positive selection in Native Americans. Hum Mol Genet. 2010;19(14):2877–85. CrossRefPubMedPubMedCentral
Lopez-Reyes A, Rodriguez-Perez JM, Fernandez-Torres J, Martinez-Rodriguez N, Perez-Hernandez N, Fuentes-Gomez AJ, et al. The HIF1A rs2057482 polymorphism is associated with risk of developing premature coronary artery disease and with some metabolic and cardiovascular risk factors. The Genetics of Atherosclerotic Disease (GEA) Mexican Study. Exp Mol Pathol. 2014;96(3):405–10. CrossRefPubMed
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001;285(19):2486–97. CrossRef
Petramala L, Chiara FM, Laura Z, Cristiano M, Giuseppina C, Luciano C, et al. Arterial Hypertension. Metabolic Syndrome and Subclinical Cardiovascular Organ Damage in Patients with Asymptomatic Primary Hyperparathyroidism before and after Parathyroidectomy: Preliminary Results. Int J Endocrinol. 2012;2012:408295.
Tassone F, Gianotti L, Baffoni C, Cesario F, Magro G, Pellegrino M, et al. Prevalence and characteristics of metabolic syndrome in primary hyperparathyroidism. J Endocrinol Invest. 2012;35(9):841–6. PubMed
Barquera S, Campos-Nonato I, Hernandez-Barrera L, Pedroza A, Rivera-Dommarco JA. Prevalence of obesity in Mexican adults 2000–2012. Salud Publica Mex. 2013;55 Suppl 2:S151–60. PubMed
Norenstedt S, Pernow Y, Brismar K, Saaf M, Ekip A, Granath F, et al. Primary hyperparathyroidism and metabolic risk factors, impact of parathyroidectomy and vitamin D supplementation, and results of a randomized double-blind study. European J Endocrinology/European Federation of Endocrine Societies. 2013;169(6):795–804. CrossRef
Elizondo-Montemayor L, Ugalde-Casas PA, Serrano-Gonzalez M, Cuello-Garcia CA, Borbolla-Escoboza JR. Serum 25-hydroxyvitamin d concentration, life factors and obesity in Mexican children. Obesity (Silver Spring). 2010;18(9):1805–11. CrossRef
Kumar S, Olukoga AO, Gordon C, Mawer EB, France M, Hosker JP, et al. Impaired glucose tolerance and insulin insensitivity in primary hyperparathyroidism. Clin Endocrinol (Oxf). 1994;40(1):47–53. CrossRef
Hernandez-Avila M, Gutierrez JP, Reynoso-Noveron N. Diabetes mellitus in Mexico. Status of the epidemic. Salud Publica Mex. 2013;55 Suppl 2:S129–36. PubMed
Campos-Nonato I, Hernandez-Barrera L, Rojas-Martinez R, Pedroza A, Medina-Garcia C, Barquera-Cervera S, et al. Hypertension: prevalence, early diagnosis, control and trends in Mexican adults. Salud Publica Mex. 2013;55 Suppl 2:S144–50. PubMed
Barquera S, Campos-Nonato I, Hernandez-Barrera L, Villalpando S, Rodriguez-Gilabert C, Durazo-Arvizu R, et al. Hypertension in Mexican adults: results from the National Health and Nutrition Survey 2006. Salud Publica Mex. 2010;52 Suppl 1:S63–71. PubMed
- High prevalence of metabolic syndrome in a mestizo group of adult patients with primary hyperparathyroidism (PHPT)
Gloria A Gonzalez-Villaseñor
Mario A Molina-Ayala
- BioMed Central
Neu im Fachgebiet Innere Medizin
Meistgelesene Bücher aus der Inneren Medizin
Mail Icon II