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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Endocrine Disorders 1/2015

High prevalence of metabolic syndrome in a mestizo group of adult patients with primary hyperparathyroidism (PHPT)

Zeitschrift:
BMC Endocrine Disorders > Ausgabe 1/2015
Autoren:
Victoria Mendoza-Zubieta, Gloria A Gonzalez-Villaseñor, Guadalupe Vargas-Ortega, Baldomero Gonzalez, Claudia Ramirez-Renteria, Moises Mercado, Mario A Molina-Ayala, Aldo Ferreira-Hermosillo
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

VMZ participated in the design of the study and helped to draft the manuscript. GAGV participated in collecting data and carried out information analysis. GVO participated in collecting data and carried out information analysis. BGV participated in collecting data and carried out information analysis. CRR helped write main draft, performed the final information and statistical analysis. MMA helped to draft the manuscript and carried out information analysis. MAMA participated in collecting data and helped to draft the manuscript. AFH helped write main draft, performed the final information and statistical analysis. All the authors read and approved the final manuscript.

Abstract

Background

Primary hyperparathyroidism (PHPT) and metabolic syndrome (MS) have been independently related to cardiovascular morbidities, however this association is still controversial. Mexican population has a high prevalence of metabolic syndrome, however its frequency seems to be even higher than expected in patients with PHPT.

Methods

We retrospectively reviewed the charts of patients that underwent parathyroidectomy for PHPT in a referral center and used the criteria from the National Cholesterol Educational Program (NCEP)/Adult Treatment Panel III (ATP III) to define MS before surgery. We compared the characteristics between the patients with and without MS.

Results

60 patients were analyzed, 77% were female and 72% had a single parathyroid adenoma. MS was present in 59% of the patients, this group was significantly older (57 vs. 48 years, p = 0.01) and they had lower iPTH (115 vs. 161 ng/ml, p = 0.017). Other parameters did not show differences.

Conclusions

MS is frequent in our population diagnosed with primary hyperparathyroidism, adverse cardiovascular parameters are common and significant differences in calcium metabolism compared to the non-MS group are present.
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