Skip to main content
Erschienen in: Infection 3/2016

25.02.2016 | Brief Report

High proportion of HIV late presenters at an academic tertiary care center in northern Germany confirms the results of several cohorts in Germany: time to put better HIV screening efforts on the national agenda?

verfasst von: Guido Schäfer, Benno Kreuels, Stefan Schmiedel, Sandra Hertling, Anja Hüfner, Olaf Degen, Jan van Lunzen, Julian Schulze zur Wiesch

Erschienen in: Infection | Ausgabe 3/2016

Einloggen, um Zugang zu erhalten

Abstract

165 treatment-naive patients who first presented at the infectious disease clinic of the University Medical Center Hamburg-Eppendorf from 2009 to 2011 were retrospectively analyzed with emphasis on patients with late presentation (LP). In line with other recent German reports, there was a large proportion of 105 of the 165 treatment-naïve patients (63.6 %) who presented late. Old age, heterosexual transmission risk and migrant background were associated risk factors for late presentation. Thus, further intensified national efforts like the HIV in Europe initiative are needed to identify such patients at high risk for HIV infection.
Literatur
1.
Zurück zum Zitat Kittner JM, von Bialy L, Wiltink J, Thomaidis T, Gospodinov B, Rieke A, Katz F, Discher T, Rath K, Claus B, Held G, Friese G, Schappert B, Schuchmann M, Galle PR. Lack of awareness in both patients and physicians contributes to a high rate of late presentation in a South West German HIV patient cohort. Infection. 2015;43(3):299–305.CrossRefPubMed Kittner JM, von Bialy L, Wiltink J, Thomaidis T, Gospodinov B, Rieke A, Katz F, Discher T, Rath K, Claus B, Held G, Friese G, Schappert B, Schuchmann M, Galle PR. Lack of awareness in both patients and physicians contributes to a high rate of late presentation in a South West German HIV patient cohort. Infection. 2015;43(3):299–305.CrossRefPubMed
2.
Zurück zum Zitat Platten M, Linnemann R, Kummerle T, Jung N, Wyen C, Ehren K, Gravemann S, Gillor D, Cornely OA, Fischer J, Lehmann C, Rockstroh JK, Fatkenheuer G, Vehreschild JJ. Clinical course and quality of care in ART-naive patients newly presenting in a HIV outpatient clinic. Infection. 2014;42(5):849–57.CrossRefPubMed Platten M, Linnemann R, Kummerle T, Jung N, Wyen C, Ehren K, Gravemann S, Gillor D, Cornely OA, Fischer J, Lehmann C, Rockstroh JK, Fatkenheuer G, Vehreschild JJ. Clinical course and quality of care in ART-naive patients newly presenting in a HIV outpatient clinic. Infection. 2014;42(5):849–57.CrossRefPubMed
3.
Zurück zum Zitat Spornraft-Ragaller P, Boashie U, Stephan V, Schmitt J. Analysis of risk factors for late presentation in a cohort of HIV-infected patients in Dresden: positive serology for syphilis in MSM is a determinant for earlier HIV diagnosis. Infection. 2013;41(6):1145–55.CrossRefPubMed Spornraft-Ragaller P, Boashie U, Stephan V, Schmitt J. Analysis of risk factors for late presentation in a cohort of HIV-infected patients in Dresden: positive serology for syphilis in MSM is a determinant for earlier HIV diagnosis. Infection. 2013;41(6):1145–55.CrossRefPubMed
4.
Zurück zum Zitat Zoufaly A, an der Heiden M, Marcus U, Hoffmann C, Stellbrink H, Voss L, van Lunzen J, Hamouda O, G. ClinSurv Study. Late presentation for HIV diagnosis and care in Germany. HIV Med. 2012;13(3):172–81.CrossRefPubMed Zoufaly A, an der Heiden M, Marcus U, Hoffmann C, Stellbrink H, Voss L, van Lunzen J, Hamouda O, G. ClinSurv Study. Late presentation for HIV diagnosis and care in Germany. HIV Med. 2012;13(3):172–81.CrossRefPubMed
5.
Zurück zum Zitat Ryom L, Boesecke C, Gisler V, Manzardo C, Rockstroh JK, Puoti M, Furrer H, Miro JM, Gatell JM, Pozniak A, Behrens G, Battegay M, Lundgren JD, E.G. Board. Essentials from the 2015 European AIDS Clinical Society (EACS) guidelines for the treatment of adult HIV-positive persons. HIV Med. 2015. Ryom L, Boesecke C, Gisler V, Manzardo C, Rockstroh JK, Puoti M, Furrer H, Miro JM, Gatell JM, Pozniak A, Behrens G, Battegay M, Lundgren JD, E.G. Board. Essentials from the 2015 European AIDS Clinical Society (EACS) guidelines for the treatment of adult HIV-positive persons. HIV Med. 2015.
6.
Zurück zum Zitat Antinori A, Coenen T, Costagiola D, Dedes N, Ellefson M, Gatell J, Girardi E, Johnson M, Kirk O, Lundgren J, Mocroft A, D’Arminio Monforte A, Phillips A, Raben D, Rockstroh JK, Sabin C, Sonnerborg A, de Wolf F, G. European Late Presenter Consensus Working. Late presentation of HIV infection: a consensus definition. HIV Med. 2011;12(1):61–4.CrossRefPubMed Antinori A, Coenen T, Costagiola D, Dedes N, Ellefson M, Gatell J, Girardi E, Johnson M, Kirk O, Lundgren J, Mocroft A, D’Arminio Monforte A, Phillips A, Raben D, Rockstroh JK, Sabin C, Sonnerborg A, de Wolf F, G. European Late Presenter Consensus Working. Late presentation of HIV infection: a consensus definition. HIV Med. 2011;12(1):61–4.CrossRefPubMed
8.
Zurück zum Zitat Smith CJ, Ryom L, Weber R, Morlat P, Pradier C, Reiss P, Kowalska JD, de Wit S, Law M, el Sadr W, Kirk O, Friis-Moller N, Monforte A, Phillips AN, Sabin CA, Lundgren JD, D.A.D.S. Group. Trends in underlying causes of death in people with HIV from 1999 to 2011 (D:A:D): a multicohort collaboration. Lancet. 2014;384(9939):241–8.CrossRefPubMed Smith CJ, Ryom L, Weber R, Morlat P, Pradier C, Reiss P, Kowalska JD, de Wit S, Law M, el Sadr W, Kirk O, Friis-Moller N, Monforte A, Phillips AN, Sabin CA, Lundgren JD, D.A.D.S. Group. Trends in underlying causes of death in people with HIV from 1999 to 2011 (D:A:D): a multicohort collaboration. Lancet. 2014;384(9939):241–8.CrossRefPubMed
9.
Zurück zum Zitat MacCarthy S, Bangsberg DR, Fink G, Reich M, Gruskin S. Late presentation to HIV/AIDS testing, treatment or continued care: clarifying the use of CD4 evaluation in the consensus definition. HIV Med. 2014;15(3):130–4.CrossRefPubMedPubMedCentral MacCarthy S, Bangsberg DR, Fink G, Reich M, Gruskin S. Late presentation to HIV/AIDS testing, treatment or continued care: clarifying the use of CD4 evaluation in the consensus definition. HIV Med. 2014;15(3):130–4.CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Mocroft A, Lundgren JD, Ross M, Law M, Reiss P, Kirk O, Smith C, Wentworth D, Neuhaus J, Fux CA, Moranne O, Morlat P, Johnson MA, Ryom L, D.A.D.s. group, C. Royal Free Hospital Clinic, I.s. group, S.s. group, E.s. group. Development and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study. PLoS Med. 2015;12(3):e1001809.CrossRefPubMedPubMedCentral Mocroft A, Lundgren JD, Ross M, Law M, Reiss P, Kirk O, Smith C, Wentworth D, Neuhaus J, Fux CA, Moranne O, Morlat P, Johnson MA, Ryom L, D.A.D.s. group, C. Royal Free Hospital Clinic, I.s. group, S.s. group, E.s. group. Development and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study. PLoS Med. 2015;12(3):e1001809.CrossRefPubMedPubMedCentral
11.
Zurück zum Zitat O’Shea D, Ebrahim M, Egli A, Redmond D, McConkey S. Late presentation of HIV despite earlier opportunities for detection, experience from an Irish tertiary referral institution. Ir J Med Sci. 2013;182(3):389–94.CrossRefPubMed O’Shea D, Ebrahim M, Egli A, Redmond D, McConkey S. Late presentation of HIV despite earlier opportunities for detection, experience from an Irish tertiary referral institution. Ir J Med Sci. 2013;182(3):389–94.CrossRefPubMed
12.
Zurück zum Zitat Agency HP. HIV in the United Kingdom: 2008 Report. London: Health Protection Agency. 2008. Agency HP. HIV in the United Kingdom: 2008 Report. London: Health Protection Agency. 2008.
13.
Zurück zum Zitat Borghi V, Girardi E, Bellelli S, Angeletti C, Mussini C, Porter K, Esposito R. Late presenters in an HIV surveillance system in Italy during the period 1992–2006. J Acquir Immune Defic Syndr. 2008;49(3):282–6.CrossRefPubMed Borghi V, Girardi E, Bellelli S, Angeletti C, Mussini C, Porter K, Esposito R. Late presenters in an HIV surveillance system in Italy during the period 1992–2006. J Acquir Immune Defic Syndr. 2008;49(3):282–6.CrossRefPubMed
14.
Zurück zum Zitat Sulis G, El Hamad I, Fabiani M, Rusconi S, Maggiolo F, Guaraldi G, Bozzi G, Bernardini C, Lichtner M, Stentarelli C, Carenzi L, Francisci D, Saracino A, Castelli F, HIV/Migrants Study Group. Clinical and epidemiological features of HIV/AIDS infection among migrants at first access to healthcare services as compared to Italian patients in Italy: a retrospective multicentre study, 2000–2010. Infection. 2014;42(5):859–67.CrossRefPubMed Sulis G, El Hamad I, Fabiani M, Rusconi S, Maggiolo F, Guaraldi G, Bozzi G, Bernardini C, Lichtner M, Stentarelli C, Carenzi L, Francisci D, Saracino A, Castelli F, HIV/Migrants Study Group. Clinical and epidemiological features of HIV/AIDS infection among migrants at first access to healthcare services as compared to Italian patients in Italy: a retrospective multicentre study, 2000–2010. Infection. 2014;42(5):859–67.CrossRefPubMed
Metadaten
Titel
High proportion of HIV late presenters at an academic tertiary care center in northern Germany confirms the results of several cohorts in Germany: time to put better HIV screening efforts on the national agenda?
verfasst von
Guido Schäfer
Benno Kreuels
Stefan Schmiedel
Sandra Hertling
Anja Hüfner
Olaf Degen
Jan van Lunzen
Julian Schulze zur Wiesch
Publikationsdatum
25.02.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Infection / Ausgabe 3/2016
Print ISSN: 0300-8126
Elektronische ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-016-0880-4

Weitere Artikel der Ausgabe 3/2016

Infection 3/2016 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.