Introduction
Materials and methods
Candidate gene | CGH probe position | Primer sequence 5′–3′ | Product position | Nucleotide substitution | Case no. |
---|---|---|---|---|---|
ADAM3A
| 102217–102276 | Forward: TATGTTACCTGTTTTCACTCCCAGT | 102137–102321 | 102240G > A | 12 |
Reverse: ACCATTCTACTTATGTGGGAGCA | |||||
108223–108282 | Forward: TGTTTTAAACGTCCTACAACTGAAC | 108111–108342 | 108225C > T | 4, 5, 8, 9, 12, 13 | |
Reverse: TGATGCTATTGGTCATTCCTCCT | |||||
ins108114ATA | 1, 2, 5, 6 | ||||
GSTT1
| 6144–6203 | Forward: ATTTCACTCTTGGCAAACATCAGGG | 5993–6312 | – | 5, 6, 8, 12 |
Reverse: GGAATGGCTTGCCTAAGACTTG |
Results
Clinicopathologic features
Case no. | Sex/age | Site of biopsy | Stage | IPI | Therapy | Response | Other sites involved | Follow-up | |
---|---|---|---|---|---|---|---|---|---|
Status | Months | ||||||||
1 | M/41 | Oropharynx | III/IV | High risk | CHOP | NR | – | D | 2 |
2 | M/47 | Nasopharynx | I/II | Low risk | RT | CR | – | A | 66 |
3 | M/31 | Nasal cavity | I/II | Low risk | RT | NR | – | D | 7 |
4 | M/42 | Nasal cavity | I/II | Low risk | RT | CR | – | D | 30 |
5 | M/33 | Nasal cavity | I/II | Low risk | RT | PR | – | D | 6 |
6 | M/39 | Nasal cavity | I/II | Low risk | RT | CR | – | D | 53 |
7 | F/28 | Nasal cavity | I/II | Low risk | CHOP + RT | CR | – | A | 60 |
8 | F/36 | Nasal cavity | I/II | Low risk | RT | NR | Orbit | D | 6 |
9 | M/41 | Nasal cavity | I/II | Low risk | CHOP | NR | – | D | 8 |
10 | M/58 | Duodenum | I/II | Low risk | CHOP | PR | – | D | 24 |
11 | M/48 | Nasal cavity | III/IV | High risk | CHOP-like | PR | Testis | D | 6 |
12 | F/60 | Skin | I/II | High risk | CHOP | NR | Nasal cavity | D | 22 |
13 | M/28 | Eyelid | I/II | Low risk | CHOP-like | NR | – | D | 2 |
Cytogenetic analysis
Cytogenetic band | Position (bp) | Candidate genes | No. of cases (case no.) | |
---|---|---|---|---|
Loss | 15q24.2 | 73419626–73419686 |
COMMD4
| 9 (3, 4, 5, 6, 8, 10, 11, 12, 13) |
19q13.32 | 53009579–53009634 | – | 9 (3, 4, 5, 6, 8, 9, 10, 12, 13) | |
5p13.2 | 37523338–37523397 |
WDR70
| 8 (4, 5, 6, 8, 9, 10, 12, 13) | |
14q21.1 | 37768843–37777108 | – | 8 (4, 5, 6, 8, 10, 11,12, 13) | |
1q21.2 | 149245378–149245437 |
FAM63A
| 7 (3, 4, 5, 6, 10, 12, 13) | |
3q21.1 | 124061602–124061661 |
DIRC2
| 6 (4, 5, 6, 8, 10, 12) | |
8p11.23 | 39368509–39441901 |
ADAM5P, ADAM3A
| 6 (5, 8, 9, 11, 12, 13) | |
13q21.1 | 52449301–52449360 | – | 6 (5, 6, 8, 10, 12, 13) | |
15q11.2 | 19537035–20308073 |
GOLGA8C, OR4M2, OR4N4, POTEB… | 5 (1, 4, 8, 10, 12) | |
20p13 | 1516966–1532485 |
SIRPB1
| 5 (5, 6, 8, 10, 12) | |
7q34 | 141699101–141711572 |
TRY6
| 5 (3, 6, 10, 11, 12) | |
14q11.1-11.2 | 18798641–19446107 |
OR4Q3, OR4M1, OR4N2, OR4K2…
| 4 (4, 6, 10, 12) | |
19q13.33 | 56828073–56840401 |
SIGLEC14
| 4 (8, 10, 11, 13) | |
22q11.23 | 22682428–22712266 |
GSTT1, GSTTP2, IGLL3, LRP5l
| 4 (5, 6, 8, 12) | |
Gain | 3q26.1 | 164101776–164101835 | – | 6 (3, 4, 6, 7, 9, 11) |
7q34 | 138381784–138416301 |
ZC3HAV1
| 5 (1, 4, 7, 10, 11) | |
8q24.3 | 141602065–146144837 |
PTK2, LY6 K, LY6E, CYC1, HSF1…
| 5 (1, 6, 7, 10, 11) | |
1p31.1 | 71302816–72568068 |
FUBP1, ZRANB2
| 4 (1, 4, 7, 11) | |
1q44 | 243072191–243106622 | – | 4 (1, 6, 7, 11) | |
2q24.1 | 157968778–158039128 |
CYTIP
| 4 (7, 8, 10, 11) | |
4q13.3 | 71740260–71751110 |
ANKRD17, GRSF1, IGJ…
| 4 (1, 7, 10, 11) | |
4q27 | 122958722–122961366 |
ANXA5, CCNA2
| 4 (1, 7, 8, 11) | |
6p21.32 | 32905664–33396254 |
TAP2, TAP1, TAPBP
| 4 (1, 7, 10, 11) | |
6q14.1 | 76019791–76031723 |
IBTK, PHIP, TMEM30A
| 4 (1, 7, 10, 11) | |
16p12.3 | 18751873–18772683 |
SMG1
| 4 (1, 7, 11, 13) |