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11.10.2015 | Original Article | Ausgabe 3/2016

Tumor Biology 3/2016

High scavenger receptor class B type I expression is related to tumor aggressiveness and poor prognosis in breast cancer

Zeitschrift:
Tumor Biology > Ausgabe 3/2016
Autoren:
Baoying Yuan, Changshun Wu, Xingwen Wang, Dan Wang, Huiling Liu, Ling Guo, Xiang-An Li, Junqing Han, Hong Feng
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s13277-015-4141-4) contains supplementary material, which is available to authorized users.
Baoying Yuan and Changshun Wu contributed equally to this work.
This work was supported by grants from the National Natural Science Foundation of China (No. 81201865 and 81202307), and Shandong Science and Technology Development Planning (No. 2011GSF11843 and 2012G0021822).

Abstract

Scavenger receptor class B type I (SR-BI) has been linked to the development and progression of breast cancer. However, its clinical significance in breast cancer remains unclear. Here, we evaluated SR-BI expression in a well-characterized breast cancer tissue microarray by immunohistochemistry. High SR-BI expression was observed in 54 % of all breast cancer cases and was significantly associated with advanced pTNM stage (P = 0.002), larger tumor size (P = 0.023), lymph node metastasis (P = 0.012), and the absence of ER (P = 0.014). The Kaplan–Meier survival analysis revealed that patients with high SR-BI expression had significantly shorter overall survival (OS) (P = 0.004). Moreover, multivariate analysis with adjustment for other prognostic factors confirmed that SR-BI was an independent prognostic factor for patient outcome (P = 0.017). Overall, our study demonstrated that high SR-BI expression was related to conventional parameters indicative of more aggressive tumor type and may serve as a new prognostic marker for poor clinical outcome in human breast cancer.

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13277_2015_4141_MOESM1_ESM.docx
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