Skip to main content
Erschienen in:

25.05.2017 | Original Article

High thoracic left sympathectomy for recalcitrant ventricular tachyarrhythmias and long QT syndrome

verfasst von: Maruti Yamanappa Haranal, Prasanna Simha, Jayaprakash Shenthar, Rakesh Rajasekharappa

Erschienen in: Indian Journal of Thoracic and Cardiovascular Surgery | Ausgabe 2/2018

Einloggen, um Zugang zu erhalten

Abstract

Background

High thoracic left sympathectomy (HTLS) is a therapeutic option for patients with recalcitrant ventricular tachyarrhythmias and long QT syndrome not fully protected by antiarrhythmics. Here, we present our experience with HTLS.

Methods

This study included 12 patients with symptomatic ventricular tachyarrhythmias refractory to antiarrhythmics, who underwent high thoracic left sympathectomy (HTLS) in our institute from 2010 to 2012. Nine were females and three were males. The mean age at HTLS was 31.25 ± 3.12 years (range 7–48 years). All underwent complete clinical evaluation. Out of 12 cases, five were diagnosed clinically as long QT syndrome (LQTS), two were catecholaminergic polymorphic ventricular tachycardia (CPVT), two were polymorphic ventricular tachycardia (PVT), and three were ventricular tachycardia (VT) storm. One patient with long QT syndrome had an implantable cardioverter defibrillator (ICD) in situ, whose battery was discharging rapidly, and another patient with long QT syndrome had an associated ASD. Three had systemic hypertension with left ventricular dysfunction. The QT interval and the QTc were recorded in those patients with LQTS both preoperatively and postoperatively at 3 months and 12 months.
Indications for surgery were recurrent episodes of syncope, symptomatic ventricular tachyarrhythmias unresponsive to antiarrhythmics, and excessive implantable cardioverter defibrillator discharges.
All patients underwent HTLS via thoracoscopically assisted mini left midaxillary approach.

Results

There were no perioperative surgical complications. One patient died due to recurrence of ventricular tachycardia storm refractory to all abortive measures. The mean follow-up period was 4.8 ± 0.96 years. All others returned to normal sinus rhythm and maintained so with additional β-blockers.

Conclusion

HTLS is an effective therapeutic option and reduces arrhythmia burden in patients with recalcitrant ventricular tachyarrhythmias and long QT syndrome.
Literatur
1.
Zurück zum Zitat Schwartz PJ, Priori SG, Spazzolini C, et al. Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation. 2001;103:89–95.CrossRefPubMed Schwartz PJ, Priori SG, Spazzolini C, et al. Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation. 2001;103:89–95.CrossRefPubMed
2.
Zurück zum Zitat Leenhardt A, Denjoy I, Guicheney P. Catecholaminergic polymorphic ventricular tachycardia. CircArrhythm Electrophysiol. 2012;5:1044–52.CrossRef Leenhardt A, Denjoy I, Guicheney P. Catecholaminergic polymorphic ventricular tachycardia. CircArrhythm Electrophysiol. 2012;5:1044–52.CrossRef
3.
Zurück zum Zitat Amin AS, Klemens CA, Verkerk AO, et al. Fever-triggered ventricular arrhythmias in Brugada syndrome and type 2 long-QT syndrome. Neth Heart J. 2010;18:165–9.CrossRefPubMedPubMedCentral Amin AS, Klemens CA, Verkerk AO, et al. Fever-triggered ventricular arrhythmias in Brugada syndrome and type 2 long-QT syndrome. Neth Heart J. 2010;18:165–9.CrossRefPubMedPubMedCentral
4.
Zurück zum Zitat Zipes DP, Camm AJ, Borggrefe M, et al. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. J Am Coll Cardiol. 2006;48:e247–346.CrossRefPubMed Zipes DP, Camm AJ, Borggrefe M, et al. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. J Am Coll Cardiol. 2006;48:e247–346.CrossRefPubMed
5.
Zurück zum Zitat Moss AJ, Zareba W, Hall WJ, et al. Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome. Circulation. 2000;101:616–23.CrossRefPubMed Moss AJ, Zareba W, Hall WJ, et al. Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome. Circulation. 2000;101:616–23.CrossRefPubMed
6.
Zurück zum Zitat Schwartz PJ, Spazzolin C, Priori SG, et al. Who are the long-QT syndrome patients who receive an implantable cardioverter-defibrillator and what happens to them? Data from the European long-QT syndrome. Implantable Cardioverter-Defibrillator (LQTSICD) Registry Circulation. 2010;122:1272–82. Schwartz PJ, Spazzolin C, Priori SG, et al. Who are the long-QT syndrome patients who receive an implantable cardioverter-defibrillator and what happens to them? Data from the European long-QT syndrome. Implantable Cardioverter-Defibrillator (LQTSICD) Registry Circulation. 2010;122:1272–82.
7.
Zurück zum Zitat Hocini M, PisonL PA, Larsen TB, Madrid A, Blomstrom-Lundqvist C. Diagnosis and management of patients with inherited arrhythmia syndromes in Europe: results of the European Heart Rhythm Association Survey. Europace. 2014;16:600–3.CrossRefPubMed Hocini M, PisonL PA, Larsen TB, Madrid A, Blomstrom-Lundqvist C. Diagnosis and management of patients with inherited arrhythmia syndromes in Europe: results of the European Heart Rhythm Association Survey. Europace. 2014;16:600–3.CrossRefPubMed
8.
Zurück zum Zitat Roston TM, Vinocur JM, Maginot KR, et al. Catecholaminergic polymorphic ventricular tachycardia in children:analysis of therapeutic strategies and outcomes from an international multicenter registry. Circ Arrhythm Electrophysiol. 2015;8:633–42.CrossRefPubMedPubMedCentral Roston TM, Vinocur JM, Maginot KR, et al. Catecholaminergic polymorphic ventricular tachycardia in children:analysis of therapeutic strategies and outcomes from an international multicenter registry. Circ Arrhythm Electrophysiol. 2015;8:633–42.CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Miyake CY, Webster G, Czosek RJ, et al. Efficacy of implantable cardio verter defibrillators in young patients with catecholaminergic polymorphic ventricular tachycardia: success depends on substrate. Circ Arrhythm Electrophysiol. 2013;6:579–87.CrossRefPubMed Miyake CY, Webster G, Czosek RJ, et al. Efficacy of implantable cardio verter defibrillators in young patients with catecholaminergic polymorphic ventricular tachycardia: success depends on substrate. Circ Arrhythm Electrophysiol. 2013;6:579–87.CrossRefPubMed
10.
Zurück zum Zitat Priori SG, Napolitano C, Memmi M, et al. Clinical and molecular characterization of patients with catecholaminergic polymorphic ventricular tachycardia. Circulation. 2002;106:69–74.CrossRefPubMed Priori SG, Napolitano C, Memmi M, et al. Clinical and molecular characterization of patients with catecholaminergic polymorphic ventricular tachycardia. Circulation. 2002;106:69–74.CrossRefPubMed
11.
Zurück zum Zitat Collura CA, Johnson JN, Moir C, Ackerman MJ. Left cardiac sympathetic denervation for the treatment of long QT syndrome and catecholaminergic polymorphic ventricular tachycardia using video-assisted thoracic surgery. Heart Rhythm. 2009;6:752–9.CrossRefPubMed Collura CA, Johnson JN, Moir C, Ackerman MJ. Left cardiac sympathetic denervation for the treatment of long QT syndrome and catecholaminergic polymorphic ventricular tachycardia using video-assisted thoracic surgery. Heart Rhythm. 2009;6:752–9.CrossRefPubMed
12.
Zurück zum Zitat Schwartz PJ, Locati EH, Moss AJ, Crampton RS, Trazzi R, Ruberti U. Left cardiac sympathetic denervation in the therapy of congenital long QT syndrome. A world wide report. Circulation. 1991;84:503–11.CrossRefPubMed Schwartz PJ, Locati EH, Moss AJ, Crampton RS, Trazzi R, Ruberti U. Left cardiac sympathetic denervation in the therapy of congenital long QT syndrome. A world wide report. Circulation. 1991;84:503–11.CrossRefPubMed
13.
Zurück zum Zitat Schwartz PJ, Priori SG, Cerrone M, et al. Left cardiac sympathetic denervation in the management of high-risk patients affected by the long-QT syndrome. Circulation. 2004;109:1826–33.CrossRefPubMed Schwartz PJ, Priori SG, Cerrone M, et al. Left cardiac sympathetic denervation in the management of high-risk patients affected by the long-QT syndrome. Circulation. 2004;109:1826–33.CrossRefPubMed
14.
Zurück zum Zitat Atallah J, Fynn-Thompson F, Cecchin F, DiBardino DJ, Walsh EP, Berul CI. Video-assisted thoracoscopic cardiac denervation: a potential novel therapeutic option for children with intractable ventricular arrhythmias. Ann Thorac Surg. 2008;6:1620–5.CrossRef Atallah J, Fynn-Thompson F, Cecchin F, DiBardino DJ, Walsh EP, Berul CI. Video-assisted thoracoscopic cardiac denervation: a potential novel therapeutic option for children with intractable ventricular arrhythmias. Ann Thorac Surg. 2008;6:1620–5.CrossRef
15.
Zurück zum Zitat Bos JM, Bos KM, Johnson JN, Moir C, Ackerman MJ. Left cardiac sympathetic denervation in long QT syndrome: analysis of therapeutic nonresponders. Circ Arrhythm Electrophysiol. 2013;6:705–11.CrossRefPubMed Bos JM, Bos KM, Johnson JN, Moir C, Ackerman MJ. Left cardiac sympathetic denervation in long QT syndrome: analysis of therapeutic nonresponders. Circ Arrhythm Electrophysiol. 2013;6:705–11.CrossRefPubMed
16.
Zurück zum Zitat De Ferrari GM, Dusi V, Spazzolini C, et al. Clinical management of catecholaminergic polymorphic ventricular tachycardia: the role of left cardiac sympathetic denervation. Circulation. 2015;131:2185–93.CrossRefPubMed De Ferrari GM, Dusi V, Spazzolini C, et al. Clinical management of catecholaminergic polymorphic ventricular tachycardia: the role of left cardiac sympathetic denervation. Circulation. 2015;131:2185–93.CrossRefPubMed
18.
19.
Zurück zum Zitat Bazett HC. An analysis of the time-relations of electrocardiograms. Heart. 1920;7:353–70. Bazett HC. An analysis of the time-relations of electrocardiograms. Heart. 1920;7:353–70.
20.
Zurück zum Zitat Moss AJ, MacDonald J. Unilateral cervicothoracic sympathetic ganglionectomy for the treatment of long QT syndrome. N Engl J Med. 1970;285:903.CrossRef Moss AJ, MacDonald J. Unilateral cervicothoracic sympathetic ganglionectomy for the treatment of long QT syndrome. N Engl J Med. 1970;285:903.CrossRef
21.
Zurück zum Zitat Schwartz PJ. The rationale and the role of left stellectomy for the prevention of malignant arrhythmias. Ann N Y Acad Sci. 1984;427:199–221.CrossRefPubMed Schwartz PJ. The rationale and the role of left stellectomy for the prevention of malignant arrhythmias. Ann N Y Acad Sci. 1984;427:199–221.CrossRefPubMed
22.
Zurück zum Zitat Schwartz PJ, Snebold NG, Brown AM. Effects of unilateral cardiac sympathetic denervation on the ventricular fibrillation threshold. Am J Cardiol. 1976;37:1034–40.CrossRefPubMed Schwartz PJ, Snebold NG, Brown AM. Effects of unilateral cardiac sympathetic denervation on the ventricular fibrillation threshold. Am J Cardiol. 1976;37:1034–40.CrossRefPubMed
23.
Zurück zum Zitat Wang LX. Role of left cardiac sympathetic denervation in themanagement of congenital long QT syndrome. J Postgrad Med. 2003;49:179–81.PubMed Wang LX. Role of left cardiac sympathetic denervation in themanagement of congenital long QT syndrome. J Postgrad Med. 2003;49:179–81.PubMed
24.
Zurück zum Zitat Epstein AE, Rosner MJ, Hageman GR, Baker 2nd JH, Plumb VJ, Kay GN. Posterior left thoracic cardiac sympathectomy by surgical division of the sympathetic chain: an alternative approach to treatment of the long QT syndrome. Pacing Clin Electrophysiol. 1996;19:1095–104.CrossRefPubMed Epstein AE, Rosner MJ, Hageman GR, Baker 2nd JH, Plumb VJ, Kay GN. Posterior left thoracic cardiac sympathectomy by surgical division of the sympathetic chain: an alternative approach to treatment of the long QT syndrome. Pacing Clin Electrophysiol. 1996;19:1095–104.CrossRefPubMed
25.
Zurück zum Zitat Olde Nordkamp LR, Driessen AH, Odero A, et al. Left cardiac sympathetic denervation in the Netherlands for the treatment of inherited arrhythmia syndromes. Neth Heart J. 2014;22:10–6.CrossRef Olde Nordkamp LR, Driessen AH, Odero A, et al. Left cardiac sympathetic denervation in the Netherlands for the treatment of inherited arrhythmia syndromes. Neth Heart J. 2014;22:10–6.CrossRef
26.
Zurück zum Zitat Schwartz PJ, Priori SG, Napolitano C. The long QT syndrome. In: Zipes DP, Jalife J, editors. Cardiac electrophysiology: from cell to bedside, 3rd eds. Philadelphia: WB Saunders; 2000. p. 597–610. Schwartz PJ, Priori SG, Napolitano C. The long QT syndrome. In: Zipes DP, Jalife J, editors. Cardiac electrophysiology: from cell to bedside, 3rd eds. Philadelphia: WB Saunders; 2000. p. 597–610.
27.
Zurück zum Zitat Priori SG, Wilde AA, Horie M, et al. HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes. Heart Rhythm. 2013;10:1932–63.CrossRefPubMed Priori SG, Wilde AA, Horie M, et al. HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes. Heart Rhythm. 2013;10:1932–63.CrossRefPubMed
28.
Zurück zum Zitat Narayanan K, Chugh SS. Sympathectomy for patients with catecholaminergic polymorphic ventricular tachycardia. Should we have the nerve? Circulation. 2015;131:2169–71.CrossRefPubMed Narayanan K, Chugh SS. Sympathectomy for patients with catecholaminergic polymorphic ventricular tachycardia. Should we have the nerve? Circulation. 2015;131:2169–71.CrossRefPubMed
29.
Zurück zum Zitat Wilde AA, Bhuiyan ZA, Crotti L, et al. Left cardiac sympathetic denervation for catecholaminergic polymorphic ventricular tachycardia. N Engl J Med. 2008;358:2024–9.CrossRefPubMed Wilde AA, Bhuiyan ZA, Crotti L, et al. Left cardiac sympathetic denervation for catecholaminergic polymorphic ventricular tachycardia. N Engl J Med. 2008;358:2024–9.CrossRefPubMed
30.
Zurück zum Zitat Scott PA, Sandilands AJ, Morris GE, et al. Successful treatment of catecholaminergic polymorphic ventricular tachycardia with bilateral thoracoscopic sympathectomy. Heart Rhythm. 2008;5:1461–3.CrossRefPubMed Scott PA, Sandilands AJ, Morris GE, et al. Successful treatment of catecholaminergic polymorphic ventricular tachycardia with bilateral thoracoscopic sympathectomy. Heart Rhythm. 2008;5:1461–3.CrossRefPubMed
Metadaten
Titel
High thoracic left sympathectomy for recalcitrant ventricular tachyarrhythmias and long QT syndrome
verfasst von
Maruti Yamanappa Haranal
Prasanna Simha
Jayaprakash Shenthar
Rakesh Rajasekharappa
Publikationsdatum
25.05.2017
Verlag
Springer Singapore
Erschienen in
Indian Journal of Thoracic and Cardiovascular Surgery / Ausgabe 2/2018
Print ISSN: 0970-9134
Elektronische ISSN: 0973-7723
DOI
https://doi.org/10.1007/s12055-017-0548-4

Neu im Fachgebiet Chirurgie

Darmpolyp weg – Peptid-Gel gegen Nachblutungen drauf?

Das Nachblutungsrisiko nach einer endoskopischen Mukosaresektion von flachen kolorektalen und duodenalen Adenomen war in der deutschen PURPLE-Studie mit einem hämostatischen Gel nicht kleiner als ohne Prophylaxe.

Krebs-Op. besser erst nach mehrwöchigem Rauchverzicht?

Aktive Raucher haben nach onkologischen Operationen ein höheres Komplikationsrisiko als Nieraucher, aber auch als Exraucher. Damit der Rauchstopp einen Nutzen hat, darf er aber nicht zu kurz vor der Op. erfolgen, wie eine Metaanalyse nahelegt.

Periprozeduraler Myokardschaden nach NSTEMI prognostisch bedeutsam

Erleiden NSTEMI-Patienten und -Patientinnen infolge einer PCI Myokardschädigungen mit oder ohne Infarkt, erhöht das die Gesamtmortalität und das Risiko für weitere schwere Herzereignisse. Dafür sprechen zumindest Daten aus zwei italienischen Zentren.

Höhere Sterberate nach Freitags-Op.

Wer direkt vor dem Wochenende operiert wird, läuft eher Gefahr, in den folgenden Wochen und Monaten zu sterben, als Menschen mit einer Op. unmittelbar nach dem Wochenende. Der Unterschied bei der Sterberate beläuft sich nach Daten einer US-Analyse auf etwa 10%.

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.