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03.07.2020 | Review Article

High-throughput nucleotide sequencing for bacteriome studies in oral squamous cell carcinoma: a systematic review

verfasst von: Ruth Tramontani Ramos, Camila Stofella Sodré, Paulo Matheus Guerra Ribeiro de Sousa Rodrigues, Alexandre Marques Paes da Silva, Milenna Silva Fuly, Henrique Fragoso dos Santos, Lucio Souza Gonçalves, Dennis de Carvalho Ferreira, Marcia Gonçalves Ribeiro

Erschienen in: Oral and Maxillofacial Surgery | Ausgabe 4/2020

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Abstract

Purpose

Dysbiosis has been identified in oral squamous cell carcinoma (OSCC). The aim of this study was to carry out a systematic review of an electronic research that was carried out on articles published between January 2008 and September 2018.

Methods

Eight studies were selected after applying the inclusion and exclusion criteria.

Results

All articles targeted the hypervariable regions of the 16S rRNA gene. At the phylum level, it was found reduction of Bacteroidetes (2/8 studies) and increase of Firmicutes (2/8 studies). At the genus level, Rothia increased (1/8 studies) and decreased (2/8 studies) in tumor samples, and Streptococcus also was found increased (3/8 studies) and reduced (3/8 studies). Fusobacterium only increased in OSCC samples (3/8 studies). At species level, an increase in F. nucleatum subsp. polymorphum was more associated to OSCC (2/8 studies) than with controls, as was P. aeruginosa (3/8 studies).

Conclusion

In summary, the results corroborated dysbiosis in OSCC patients, with enrichment of microbial taxa that are associated with inflammation and production of acetaldehyde. However, variations of study design and sample size were observed among the studies, as well as a shortage of more detailed analyses of possible correlations between risk habits and OSCC. This lack of more detailed analysis may be the cause of the inconsistencies in regard of the alterations reported for certain genera and species. In conclusion, there is an association between OSCC and oral microbiota dysbiosis, but its role in oral carcinogenesis needs to be clarified in more detail.

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Titel: High-throughput nucleotide sequencing for bacteriome studies in oral squamous cell carcinoma: a systematic review
verfasst von: Ruth Tramontani Ramos
Camila Stofella Sodré
Paulo Matheus Guerra Ribeiro de Sousa Rodrigues
Alexandre Marques Paes da Silva
Milenna Silva Fuly
Henrique Fragoso dos Santos
Lucio Souza Gonçalves
Dennis de Carvalho Ferreira
Marcia Gonçalves Ribeiro
Publikationsdatum: 03.07.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Oral and Maxillofacial Surgery / Ausgabe 4/2020
Print ISSN: 1865-1550
Elektronische ISSN: 1865-1569
DOI: https://doi.org/10.1007/s10006-020-00873-4

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