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01.12.2012 | Original investigation | Ausgabe 1/2012 Open Access

Cardiovascular Diabetology 1/2012

Higher normal ranges of urine albumin-to-creatinine ratio are independently associated with carotid intima-media thickness

Zeitschrift:
Cardiovascular Diabetology > Ausgabe 1/2012
Autoren:
Sun-Seog Kweon, Min-Ho Shin, Young-Hoon Lee, Jin-Su Choi, Hae-Sung Nam, Kyeong-Soo Park, Do-Hyung Kim, Seul-Ki Jeong
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1475-2840-11-112) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

SSK, MHS, YHL, JSC, HSN, KSP, and SKJ performed the community cohort. SSK and SKJ performed all the data extraction and computation independently. SKJ wrote the paper. DHK, MHS, YHL, JSC, HSN, and KSP took part in writing the paper. All authors reviewed and agreed the final version of manuscript. All authors read and approved the final manuscript.

Abstract

Background

High normal values of urine albumin-to-creatinine ratio (UACR) have been reported to have predictive values for hypertension, incident stroke, and higher mortality in the general population. This study aimed to investigate the association between normal ranges of UACR and carotid intima-media thickness (CIMT) in adult population.

Methods

We performed a cross-sectional study in adults aged 45 to 74 years who were living in Namwon City, South Korea. Both common CIMTs were measured, and mean values were calculated. Normal values of UACR were defined as <30mg/g and categorized into quintiles; less than 6.50, 6.51-9.79, 9.80-13.49, 13.50-18.89, and more than 18.90 mg/g. The association between the quintiles of UACR and common CIMT was analyzed and stratified by sex.

Results

A total of 7555 participants (3084 men and 4471 women) with normal UACR were enrolled in the present study. Common CIMT was positively and independently associated with increasing quintiles of UACR in men and women, even after adjusting for potential confounders including age and cardiovascular risk factors. Compared to the first quintile, the fifth quintile showed odds ratios of 1.80 (95% confidence intervals, 1.26-2.55) and 1.97 (1.28-3.04) for increased CIMT (>0.9mm) in men and women, respectively.

Conclusion

Higher UACR values within normal ranges (<30 mg/g) were positively and independently associated with CIMT in a Korean general population, suggesting that higher normal values of UACR might be a risk marker of subclinical carotid atherosclerosis.
Zusatzmaterial
Authors’ original file for figure 1
12933_2012_566_MOESM1_ESM.jpeg
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