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Higher Postoperative Mortality and Inferior Survival After Right-Sided Liver Resection for Perihilar Cholangiocarcinoma: Left-Sided Resection is Preferred When Possible
A right- or left-sided liver resection can be considered in about half of patients with perihilar cholangiocarcinoma (pCCA), depending on tumor location and vascular involvement. This study compared postoperative mortality and long-term survival of right- versus left-sided liver resections for pCCA.
Methods
Patients who underwent major liver resection for pCCA at 25 Western centers were stratified according to the type of hepatectomy—left, extended left, right, and extended right. The primary outcomes were 90-day mortality and overall survival (OS).
Results
Between 2000 and 2022, 1701 patients underwent major liver resection for pCCA. The 90-day mortality was 9% after left-sided and 18% after right-sided liver resection (p < 0.001). The 90-day mortality rates were 8% (44/540) after left, 11% (29/276) after extended left, 17% (51/309) after right, and 19% (108/576) after extended right hepatectomy (p < 0.001). Median OS was 30 months (95% confidence interval [CI] 27–34) after left and 23 months (95% CI 20–25) after right liver resection (p < 0.001), and 33 months (95% CI 28–38), 27 months (95% CI 23–32), 25 months (95% CI 21–30), and 21 months (95% CI 18–24) after left, extended left, right, and extended right hepatectomy, respectively (p < 0.001). A left-sided resection was an independent favorable prognostic factor for both 90-day mortality and OS compared with right-sided resection, with similar results after excluding 90-day fatalities.
Conclusions
A left or extended left hepatectomy is associated with a lower 90-day mortality and superior OS compared with an (extended) right hepatectomy for pCCA. When both a left and right liver resection are feasible, a left-sided liver resection is preferred.
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For patients diagnosed with perihilar cholangiocarcinoma (pCCA), complete surgical resection of the tumor is the only treatment that offers a chance for long-term survival. Only a minority of about 15% of patients with pCCA can undergo surgical resection.1 Reported 5-year survival rates after resection range from 21 to 35%.2,3 With palliative chemotherapy, the median overall survival (OS) is 12 months, and only 3 months without treatment.1,4,5
Complete resection of pCCA usually requires an extrahepatic bile duct resection combined with major hepatectomy. These extensive surgical procedures are associated with high risks of liver failure, with a postoperative 90-day mortality rate of 12% in a recent systematic review.6 Postoperative mortality is mostly explained by postoperative liver failure.7 Numerous small single-center studies have compared the outcomes for patients with pCCA after left and right hepatectomy.8,9 In some patients, unilateral liver atrophy or portal vein involvement dictate the side of liver resection. In other patients, both a left- and right-sided resection can aim for a complete (i.e., R0) resection. The advantage of a right-sided liver resection is the long left hepatic ductal margin.10 However, a right-sided liver resection is associated with a higher risk of postoperative mortality, because of a smaller liver remnant, compared with left-sided resections.11,12 It remains uncertain whether the added oncological benefit of a wider margin outweighs the increased surgical risk of a right-sided resection.
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This study aimed to compare 90-day postoperative mortality and long-term OS between right- and left-sided major liver resections in the pCCA collaboration group.
Methods
All consecutive patients aged 18 years or older who underwent resection of proven or suspected pCCA at 25 European and American centers, during various periods after 2000, were included in the collaborative database. Data were collected through a standardized and pseudo-anonymous data file. The definition of pCCA was a biliary tumor originating between the segmental bile ducts and cystic duct. The Institutional Medical Ethics Committee of Erasmus MC waived the need for ethical approval. The study was conducted in adherence with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines.
The work-up and management of patients included in the study differed across the centers and during the period of inclusion. Major liver resection was defined as resection of at least three Couinaud liver segments;13 left hepatectomy was defined as the resection of liver segments 2, 3, and 4, with or without segment 1; right hepatectomy was defined as the resection of liver segments 5, 6, 7, and 8, with or without segment 1; and an extended liver resection was defined as any extension beyond a formal left or right hepatectomy. Left-sided resections include both left and extended left hepatectomy, and right-sided resections include both right and extended right hepatectomy. Preoperative cholangitis was defined as fever and leukocytosis requiring (additional) biliary drainage in accordance with the definitions applied in the DRAINAGE trial.14 Tumors were classified according to the Bismuth–Corlette classification. Negative resection margins were defined as tumor-free margins in all resection margins reported in the pathology report. All complications within 30 days after surgery or during initial hospitalization were scored and classified according to the classification proposed by Dindo et al. 15 Postoperative mortality was defined as mortality within 90 days after surgery. Liver failure, biliary leakage, and hemorrhage were scored and graded according to the respective International Study Group of Liver Surgery (ISGLS) criteria, and only grades B and C were considered clinically relevant.16‐18 OS was defined as the time between surgery and death or last follow-up.
All categorical variables were shown as numbers with percentages and differences were tested using the Chi-square or Fisher’s exact test where appropriate. Continuous variables were shown as medians with interquartile ranges (IQR) and differences were tested using Kruskal–Wallis tests. Survival rates and hazard ratios were shown as medians with 95% confidence intervals (CIs). Survival curves were generated using the Kaplan–Meier method and differences between groups were tested using log-rank tests. Median follow-up was calculated using the reverse Kaplan–Meier method. Univariable and multivariable analysis to identify factors associated with 90-day mortality were performed using binary logistic regression analysis, and the analyses for OS were performed using Cox regression analysis in accordance with the TRIPOD checklist. All variables with a p-value <0.1 at univariable analysis were included in the multivariable analysis. All statistical analyses were performed using SPSS version 26 (IBM Corporation, Armonk, NY, USA) and figures were generated using GraphPad version 9 (GraphPad, La Jolla, CA, USA).
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Results
A total of 2065 patients underwent resection for proven or suspected pCCA across 25 centers. Patients who had a postoperative diagnosis other than pCCA (n = 178) were excluded, as were patients who only underwent an extrahepatic bile duct resection without liver resection (n = 146) and patients who underwent minor liver resection (n = 40). The remaining 1701 patients were included in the analyses, with a median center volume of 62 (33–79).
Clinicopathological characteristics as well as outcomes of patients according to the type of hepatectomy performed are shown in Table 1. Extended right hepatectomy was the most frequent resection (n = 576, 34%), followed by left hepatectomy (n = 540, 32%), right hepatectomy (n = 309, 18%), and extended left hepatectomy (n = 276, 16%). Patients who underwent an extended right hepatectomy were younger compared with patients undergoing the other types of resection (62 vs. 66 years; p < 0.001), and more frequently underwent preoperative biliary drainage (89% vs. 79%; p < 0.001). Portal vein reconstruction was performed in 45% of patients who underwent an extended hepatectomy, compared with 18% with a formal right or left hepatectomy (p < 0.001). Nodal status and resection margin were similar across the different types of hepatectomy.
Table 1
Patient and disease characteristics as well as outcomes according to the type of hepatectomy performed for perihilar cholangiocarcinoma
Type of hepatectomy performed
All
Left [n = 540]
Extended left [n = 276]
Right [n = 309]
Extended right [n = 576]
p-Value
Age, years [median (IQR)]
65 (57–72)
66 (57–72)
66 (57–73)
67 (59–73)
62 (54–70)
<0.001
Male sex
981 (58)
332 (61)
154 (56)
193 (62)
302 (52)
0.003
ASA score III/IV
545 (32)
181 (34)
101 (37)
96 (31)
167 (29)
0.110
Bismuth classification
<0.001
I/II
244 (14)
82 (15)
17 (6)
75 (24)
70 (12)
IIIA
540 (32)
38 (7)
49 (18)
159 (52)
294 (52)
IIIB
448 (26)
312 (59)
99 (37)
12 (4)
25 (4)
IV
440 (26)
100 (19)
106 (39)
61 (20)
173 (31)
Preoperative biliary drainage
<0.001
None
295 (17)
133 (25)
45 (16)
56 (18)
58 (11)
PTBD
412 (24)
145 (27)
63 (23)
94 (30)
110 (19)
EBD
749 (44)
197 (36)
137 (50)
127 (41)
288 (50)
Both
248 (15)
65 (12)
31 (11)
32 (10)
120 (21)
Preoperative cholangitis
342 (20)
111 (21)
44 (16)
73 (24)
114 (20)
0.139
Portal vein embolization
331 (19)
19 (4)
4 (1)
61 (20)
247 (43)
<0.001
Portal vein reconstruction
535 (31)
90 (17)
105 (38)
62 (20)
278 (48)
<0.001
Node positive (pN+)
717 (42)
217 (40)
122 (44)
132 (43)
246 (43)
0.703
Metastatic disease
74 (4)
21 (4)
11 (4)
8 (3)
34 (6)
0.117
Negative margin
1109 (65)
365 (68)
169 (61)
209 (68)
376 (65)
0.265
Poor differentiation
390 (23)
101 (19)
79 (29)
75 (24)
135 (23)
0.012
Perineural invasion
1133 (66)
348 (64)
174 (63)
199 (64)
412 (71)
0.177
Major morbidity
831 (49)
208 (39)
126 (46)
162 (52)
335 (58)
<0.001
Liver failure, ISGLS B/C
274 (16)
48 (9)
32 (12)
58 (19)
136 (23)
<0.001
Biliary Leakage, ISGLS B/C
339 (20)
103 (19)
64 (23)
59 (19)
113 (19)
0.516
Hemorrhage, ISGLS B/C
112 (7)
28 (5)
19 (7)
22 (7)
43 (7)
0.462
30-day mortality
149 (9)
31 (6)
16 (6)
32 (10)
70 (12)
<0.001
90-day mortality
232 (14)
44 (8)
29 (11)
51 (17)
108 (19)
<0.001
Data are expressed as n (%) unless otherwise specified
ASA American society of anesthesiologists, PTBD Percutaneous transhepatic biliary drainage, EBD Endoscopic biliary drainage, ISGLS International study group of liver surgery, IQR Interquartile range
The 90-day mortality was 9% after left-sided liver resection and 18% after right-sided liver resection (p < 0.001). The 90-day mortality rates were 8% (44/540) after left, 11% (29/276) after extended left, 17% (51/309) after right, and 19% (108/576) after extended right hepatectomy (p < 0.001). Similarly, post-hepatectomy liver failure rates were 9% (48/309), 12% (32/276), 19% (58/309), and 24% (136/576) after left, extended left, right, and extended right hepatectomy, respectively (p < 0.001).
Independent risk factors for 90-day mortality were right (odds ratio [OR] 2.17, 95% CI 1.30–3.60) and extended right liver resection (OR 2.59, 95% CI 1.63–4.14) when compared with left liver resection (Table 2). Other independent risk factors were age (OR 1.03, 95% CI 1.02–1.05), American Society of Anesthesiologists (ASA) III/IV (OR 1.44, 95% CI 1.05–1.97), and preoperative cholangitis (OR 1.48, 95% CI 1.04–2.11).
Table 2
Univariable and multivariable analysis for 90-day mortality after surgery for perihilar cholangiocarcinoma
Univariable
Multivariable
OR (95% CI)
p-Value
OR (95% CI)
p-Value
Age
1.03 (1.02–1.05)
<0.001
1.03 (1.02–1.05)
<0.001
Male sex
1.19 (0.89–1.57)
0.239
ASA score III/IV vs. I/II
1.59 (1.19–2.13)
0.002
1.44 (1.05–1.97)
0.022
Bismuth type
I/II
Reference
Reference
IIIA
1.02 (0.67–1.55)
0.928
0.78 (0.50–1.21)
0.265
IIIB
0.59 (0.37–0.94)
0.026
0.88 (0.52–1.51)
0.648
IV
0.98 (0.63–1.51)
0.916
0.89 (0.56–1.42)
0.617
Tumor size, >3 cm
1.35 (0.99–1.85)
0.061
1.29 (0.95–1.76)
0.101
Biliary drainage
1.39 (0.93–2.07)
0.112
1.13 (0.71–1.80)
0.614
Preoperative cholangitis
1.44 (1.04–2.00)
0.030
1.48 (1.04–2.11)
0.031
Type of hepatectomy
Left
Reference
Reference
Extended left
1.32 (0.81–2.16)
0.269
1.16 (0.69–1.95)
0.580
Right
2.22 (1.45–3.42)
<0.001
2.17 (1.30–3.60)
0.003
Extended right
2.61 (1.80–3.79)
<0.001
2.59 (1.63–4.14)
<0.001
Portal vein resection
1.50 (1.13–2.00)
0.005
1.35 (0.98–1.85)
0.066
ASA American society of anesthesiologists, CI Confidence interval, OR Odds ratio
At last follow-up, 1145 patients had died, with a median follow-up of survivors of 63 months (95% CI 57–68). The median OS was 26 months (95% CI 25–28), with a 5-year OS of 25%. Median OS was 30 months (95% CI 27–34) after left and 23 months (95% CI 20–25) after right liver resection (p < 0.001). Survival curves for each type of hepatectomy are shown in Fig. 1. Median OS was 33 months (95% CI 28–38) after left, 27 months (95% CI 23–32) after extended left, 25 months (95% CI 21–30) after right, and 21 months (95% CI 18–24) after extended right hepatectomy (p < 0.001). The 1-year survival rates were 77% after left, 73% after extended left, 68% after right, and 65% after extended right hepatectomy. After exclusion of patients who died within 90 days after surgery, median OS was 37 months (95% CI 33–42) after left, 32 months (95% CI 27–36) after extended left, 33 months (95% CI 26–41) after right, and 28 months (95% CI 25–32) after extended right hepatectomy (p = 0.019).
Fig. 1
Overall survival of patients who underwent major liver resection for perihilar cholangiocarcinoma according to the type of hepatectomy
After adjusting for other independent prognostic factors, the differences in survival between (extended) right and (extended) left hepatectomy remained (Table 3). Similar results for OS were found after excluding patients with 90-day postoperative mortality (Online Resource Table S2).
Table 3
Univariable and multivariable analysis for overall survival after resection of perihilar cholangiocarcinoma
Univariable
Multivariable
HR (95% CI)
p-Value
HR (95% CI)
p-Value
Age
1.01 (1.00–1.01)
0.052
1.01 (1.00–1.01)
0.005
Male sex
1.17 (1.03–1.31)
0.012
1.17 (1.04–1.32)
0.011
ASA score III/IV vs. I/II
1.39 (1.24–1.57)
<0.001
1.25 (1.09–1.42)
0.001
Bismuth type
I/II
Reference
Reference
IIIA
1.17 (0.97–1.42)
0.102
0.91 (0.74–1.11)
0.358
IIIB
1.04 (0.86–1.27)
0.680
1.05 (0.85–1.31)
0.635
IV
1.34 (1.11–1.64)
0.003
1.03 (0.83–1.27)
0.789
Tumor size, >3 cm
1.22 (1.07–1.39)
0.003
1.12 (0.98–1.28)
0.103
Biliary drainage
1.21 (1.03–1.42)
0.020
1.01 (0.83–1.22)
0.957
Preoperative cholangitis
1.17 (1.01–1.36)
0.036
1.10 (0.95–1.29)
0.214
Type of hepatectomy
Left
Reference
Reference
Extended left
1.23 (1.03–1.47)
0.023
1.15 (0.95–1.39)
0.156
Right
1.23 (1.03–1.47)
0.021
1.39 (1.13–1.71)
0.002
Extended right
1.41 (1.22–1.63)
<0.001
1.46 (1.21–1.75)
<0.001
Portal vein resection
1.25 (1.11–1.42)
<0.001
1.08 (0.94–1.25)
0.260
Caudate lobe resection
0.99 (0.87–1.14)
0.973
Node positive (pN+)
1.89 (1.67–2.13)
<0.001
1.68 (1.48–1.90)
<0.001
Metastatic disease
1.57 (1.19–2.07)
0.001
1.21 (0.90–1.61)
0.203
Positive margin
1.63 (1.44–1.84)
<0.001
1.43 (1.26–1.63)
<0.001
Poor differentiation
1.60 (1.38–1.85)
<0.001
1.35 (1.17–1.55)
<0.001
Perineural invasion
1.48 (1.26–1.73)
<0.001
1.26 (1.07–1.48)
0.005
ASA American society of anesthesiologists, CI Confidence interval, HR Hazard ratio
In the subgroup of Bismuth type I and II tumors, the median OS was 54 months (41–67) after left hepatectomy, compared with 30 months (12–49) after extended left, 26 months (14–17) after right, and 18 months (9–27) after extended right hepatectomy (p < 0.001) [Fig. 2a]. R0 margins were achieved in 81%, 53%, 75%, and 76% of left, extended left, right, and extended right hepatectomy, respectively (p = 0.122). For Bismuth type IV tumors, the median OS was 22 months (14–31) after left, 26 months (22–30) after extended left, 25 months (22–28) after right, and 21 months (14–28) after extended right hepatectomy (p = 0.824) [Fig. 2b]. R0 margins were achieved in 56%, 58%, 58%, 65% of left, extended left, right, and extended right hepatectomy, respectively (p = 0.160).
Fig. 2
Overall survival after resection for Bismuth type A I/II and B IV perihilar cholangiocarcinoma according to the type of hepatectomy. Differences were tested using log-rank tests, and the numbers of patients at risk are shown below the graph
This study of 1701 patients who underwent major liver resection for pCCA showed that 90-day mortality was 9% after (extended) left hepatectomy and 18% after (extended) right hepatectomy (p < 0.001). OS was also better after (extended) left hepatectomy (30 months) compared with (extended) right liver resection (21 months). This difference remained present after adjusting for all relevant prognostic variables and remained after exclusion of patients who died within 90 days after surgery.
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Several tumor characteristics can dictate the type of liver resection. Unilateral atrophy is observed in about one-third of patients and dictates ipsilateral resection.7 The extent of tumor mass towards the left or right liver (i.e. Bismuth 3A or 3B) may guide many surgeons to resecting the ipsilateral side (i.e., right-sided resection for 3A).19 Involvement of hilar vessels, most commonly the left portal vein or right hepatic artery, can also guide surgeons to resecting the ipsilateral side to avoid a vascular reconstruction.10,20 In patients without atrophy and without unilateral biliary tumor extension, both a left- and right-sided resection can be considered.
Numerous studies have investigated left versus right liver resection for patients with pCCA. All studies on this topic were retrospective and mostly single-center series from expert centers including fewer than 200 patients. Most studies reported similar perioperative and survival outcomes for patients who underwent a left or right liver resection.8,21‐25 An Italian series of 124 patients reported a more than threefold higher postoperative mortality rate in right-sided resection,9 while a larger French study with 366 patients reported a twofold higher mortality in right-sided resections.26 The twofold difference in mortality is comparable with the current study.
The main downside of right-sided liver resections is the smaller remnant liver that predisposes patients to post-hepatectomy liver failure and mortality. In the literature, 90-day mortality rates are 1.5–4-fold higher after right- compared with left-sided liver resection for pCCA.9,11,27 Most deaths (about 90%) after surgery for pCCA are due to liver failure.27 On average, the right hemi-liver is twice as large as the left hemi-liver. After an extended right hemi-hepatectomy, only segments 2 and 3 remain. These two segments generally constitute only 5–27% of the total liver volume.28 In the presence of preoperative cholangitis (about 25% of patients), the risk of postoperative liver failure becomes even higher.7,12,26,29 Preoperative optimization with portal vein embolization (PVE) aims to increase the future liver remnant volume and function.26,30 PVE can result in a threefold reduction of liver failure in patients with pCCA.7 In the present study, PVE was only performed in 20% of right resections and 43% of extended right resections.
Long-term survival in this report was higher for patients who underwent (extended) left hepatectomy after adjusting for known independent prognostic factors. This was partially attributable to lower perioperative mortality after (extended) left hepatectomy, but OS remained superior after exclusion of patients with 90-day postoperative mortality. Previous single-center studies of fewer than 200 patients, and a meta-analysis including 1031 patients, did not find better survival for left-sided hepatectomies compared with other hepatectomies.8,25,31 The smaller sample size may explain why other studies did not find a difference in OS between left- and right-sided resections. An Italian series found a 10-month longer OS after right liver resections, which may also be attributed to the smaller sample size.9 This study is the largest to date on this topic and challenges the proposed oncologic superiority of extended right liver resection.10 The supposed higher R0 resection rate with extended right liver resection was not present in this real-world multicenter study.
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This study has several limitations, which are mostly related to the retrospective study design, which is subject to selection bias. The retrospective, multicenter design resulted in differences in diagnostic work-up and treatment across centers. The criteria that centers used for a left- or right-sided resection were not recorded. However, the different approach of centers was also an advantage of this study. It allowed to compare similar patients who underwent different treatments (i.e., left- or right-sided resection). Although in many patients the decision to perform a left or right liver resection will be determined by tumor characteristics, the estimate of 90-day mortality and long-term OS remains relevant in the decision process and can guide the process for those patients in whom both left- and right-sided resection are feasible. Although a multivariable analysis was performed to correct for the decision to perform a certain type of liver resection, it could be that unrecorded factors still have guided the clinical decision to perform a left or right liver resection. For instance, the relatively low number of patients who underwent PVE before extended right liver resection could indicate right portal vein involvement with consequent left liver hypertrophy in some patients.
Conclusion
This study showed that for patients with pCCA, a left hemihepatectomy is associated with less postoperative liver failure and 90-day mortality compared with right resections. Long-term prognosis was better for patients after left hemihepatectomy, even after the exclusion of all 90-day postoperative fatalities. When both a left and right liver resection is technically feasible in a patient with pCCA, a left-sided liver resection is preferred.
Acknowledgments
Prof. Ulf Neumann has undertaken relevant financial activities outside the submitted work for Merck AG, Dr. Falk, AstraZeneca, and Roche AG. Perihilar cholangiocarcinoma collaboration group: (PubMed citable collaborative authorship). Aldrighetti L, Bartsch F, Bechstein WO, Bednarsch J, Benzing C, de Boer MA, Bouwense SA, Capobianco I, Cescon M, D'Angelica MI, Dewulf M, de Reuver P, de Savornin Lohman E, Efanov M, Franken LC, Geers J, Giglio MC, Gilg S, Gomez-Gavara C, van Gulik TM, Heil J, IJzermans JNM, Jansson H, Kingham TP, Lodge P, Margies R, Marino R, Molenaar QI, Nguyen TA, Nooijen LE, Nota C.L.M, Poletto E,Porte RJ, Prasad R, Quinn LM, Rolinger J, Ruzzenente A, Schmelzle M, Serenari M, Sultana A, van Laarhoven S, Zonderhuis BM.
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Higher Postoperative Mortality and Inferior Survival After Right-Sided Liver Resection for Perihilar Cholangiocarcinoma: Left-Sided Resection is Preferred When Possible
Verfasst von
Pim B. Olthof, MD, PhD
Joris I. Erdmann, MD, PhD
Ruslan Alikhanov, MD, PhD
Ramón Charco, MD, PhD
Alfredo Guglielmi, MD, PhD
Jeroen Hagendoorn, MD, PhD
Abdul Hakeem, MD, PhD
Frederik J. H. Hoogwater, MD, PhD
William R. Jarnagin, MD, PhD
Geert Kazemier, MD, PhD
Hauke Lang, MD, PhD
Shishir K. Maithel, MD, PhD, FACS
Massimo Malago, MD, PhD
Hassan Z. Malik, MD, PhD
Silvio Nadalin, MD, PhD
Ulf Neumann, MD, PhD
Steven W. M. Olde Damink, MD, PhD
Johann Pratschke, MD, PhD
Francesca Ratti, MD, PhD
Matteo Ravaioli, MD, PhD
Keith J. Roberts, MD, PhD
Erik Schadde, MD
Andreas A. Schnitzbauer, MD, PhD
Ernesto Sparrelid, MD, PhD
Baki Topal, MD, PhD
Roberto I. Troisi, MD, PhD
Bas Groot Koerkamp, MD, PhD
Perihilar Cholangiocarcinoma Collaboration Group
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Das Thema Ergonomie am Arbeitsplatz wird in chirurgischen Abteilungen viel zu oft stiefmütterlich behandelt. Die Konsequenzen macht die ERGO-Studie deutlich: Fehlhaltungen und Schmerzen hängen demnach eng zusammen.
Relevante Koronarstenosen vor einer Transkatheter-Aortenklappen-Intervention (TAVI) interventionell statt rein medikamentös zu behandeln, bietet Registerdaten zufolge einen überschaubaren klinischen Nutzen zum Preis eines erhöhten Blutungsrisikos.
Ob älteren Menschen mit geplanter Operation im Krankenhaus ein geriatrischer Versorgungspfad offensteht oder nicht, hat Konsequenzen für die Dauer des stationären Aufenthalts.
Bei M. Crohn mit isoliertem Befall der Ileozökalregion scheint die frühzeitige chirurgische Therapie auch auf lange Sicht eine gute Alternative zu Biologika zu sein. Zehn Jahre nach der OP waren in der LIR!C-Studie noch deutlich mehr Patienten therapiefrei in Remission.
