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09.05.2024 | Original Paper

Hinokione: an abietene diterpene with pancreatic β cells regeneration and hypoglycemic activity, and other derivatives with novel structures from the woods of Agathis dammara

verfasst von: Zheng Wang, Zhe-Wei Yu, Yi Zhang, Wen-Hui Wang, Xin-Yi Wu, Shun-Zhi Liu, Yan-Lin Bin, Bang-Ping Cai, Shi-Yan Huang, Mei-Juan Fang, Rong Qi, Ming-Yu Li, Ying-Kun Qiu

Erschienen in: Journal of Natural Medicines | Ausgabe 4/2024

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Abstract

In this study, 14 abietene and pimarene diterpenoids were isolated from the woods of Agathis dammara. Among them, 4 new compounds, dammarone A-C and dammaric acid A (1–4), were firstly reported, respectively. The structure of the new compounds was determined by HR ESI–MS and 1D/2D NMR spectroscopy, and their absolute configuration was determined by electronic circular dichroism (ECD) exciton chirality method. The hypoglycemic effect of all compounds was evaluated by transgenic zebrafish model, and the structure–activity relationship was discussed. Hinokione (7, HO) has low toxicity and significant hypoglycemic effects on zebrafish, the mechanism is mainly by promoting the differentiation of zebrafish pancreatic endocrine precursor cells (PEP cells) into β cells, thereby promoting the regeneration of pancreatic β cells.

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Titel: Hinokione: an abietene diterpene with pancreatic β cells regeneration and hypoglycemic activity, and other derivatives with novel structures from the woods of Agathis dammara
verfasst von: Zheng Wang
Zhe-Wei Yu
Yi Zhang
Wen-Hui Wang
Xin-Yi Wu
Shun-Zhi Liu
Yan-Lin Bin
Bang-Ping Cai
Shi-Yan Huang
Mei-Juan Fang
Rong Qi
Ming-Yu Li
Ying-Kun Qiu
Publikationsdatum: 09.05.2024
Verlag: Springer Nature Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 4/2024
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-024-01816-z

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Springer Medizin

Hinokione: an abietene diterpene with pancreatic β cells regeneration and hypoglycemic activity, and other derivatives with novel structures from the woods of Agathis dammara

Abstract

Graphical abstract

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Development of a determination method for quality control markers utilizing metabolic profiling and its application on processed Zingiber officinale Roscoe rhizome

Daphnane diterpenoid orthoesters with an odd-numbered aliphatic side chain from Daphne pedunculata

Five pimarane diterpenoids from Kaempferia champasakensis and their cytotoxic activities

Germacrone, isolated from Curcuma wenyujin, inhibits melanin synthesis through the regulation of the MAPK signaling pathway

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