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2015 | OriginalPaper | Buchkapitel

34. Hirntumoren

verfasst von : Michael Weller, Prof. Dr., Uwe Schlegel, Prof. Dr., Kirsten Schmieder, Prof. Dr.

Erschienen in: NeuroIntensiv

Verlag: Springer Berlin Heidelberg

Zusammenfassung

Hirntumoren treten entweder als primäre Erkrankungen des Nervensystems oder sekundär als Komplikation metastatischer, primär extrazerebraler Tumorerkrankungen auf. Die Prognose der primären Tumoren ist in Abhängigkeit von Histologie und Erkrankungsalter sehr unterschiedlich. Etwa 20 % aller Patienten mit extrazerebralen Tumoren entwickeln Hirnmetastasen. Diese tragen erheblich zur Morbidität bei und sind eine häufige Todesursache.
Literatur
1.
Zurück zum Zitat Anderson GD, Lin YX, Berge C, Ojemann GA (1997) Absence of bleeding complications in patients undergoing cortical surgery while receiving valproate treatment. J Neurosurg 87:252–256CrossRefPubMed Anderson GD, Lin YX, Berge C, Ojemann GA (1997) Absence of bleeding complications in patients undergoing cortical surgery while receiving valproate treatment. J Neurosurg 87:252–256CrossRefPubMed
2.
Zurück zum Zitat Brandsma D, Stalpers L, Taal W, Sminia P, Van den Bent MJ (2008) Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas. Lancet Oncol 9:453–461CrossRefPubMed Brandsma D, Stalpers L, Taal W, Sminia P, Van den Bent MJ (2008) Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas. Lancet Oncol 9:453–461CrossRefPubMed
3.
4.
Zurück zum Zitat Deutsche Gesellschaft für Neurologie, Diener HC, Weimar C, Berlit P, Deuschl G, Elger C, Gold R, Hacke W, Hufschmidt A, Mattle H, Meier U, Oertel WH, Reichmann H, Schmutzhard E, Wallesch CW, Weller M (Hrsg) (2012) Leitlinien für Diagnostik und Therapie in der Neurologie. Gliome. Thieme, Stuttgart, S 922–940 Deutsche Gesellschaft für Neurologie, Diener HC, Weimar C, Berlit P, Deuschl G, Elger C, Gold R, Hacke W, Hufschmidt A, Mattle H, Meier U, Oertel WH, Reichmann H, Schmutzhard E, Wallesch CW, Weller M (Hrsg) (2012) Leitlinien für Diagnostik und Therapie in der Neurologie. Gliome. Thieme, Stuttgart, S 922–940
5.
Zurück zum Zitat Fischer L, Martus P, Weller M, Klasen HA, Rohden B, Röth A, Storek B, Hummel M, Nägele T, Thiel E, Korfel A (2008) Meningeal dissemination in primary CNS lymphoma: Prospective evaluation of 282 patients. Neurology 71:1102–1108CrossRefPubMed Fischer L, Martus P, Weller M, Klasen HA, Rohden B, Röth A, Storek B, Hummel M, Nägele T, Thiel E, Korfel A (2008) Meningeal dissemination in primary CNS lymphoma: Prospective evaluation of 282 patients. Neurology 71:1102–1108CrossRefPubMed
6.
Zurück zum Zitat Juergens A, Pels H, Rogowski S, Fliessbach K, Glasmacher A, Engert A, Reiser M, Diehl V, Vogt-Schaden M, Egerer G, Schackert G, Reichmann H, Kroschinsky F, Bode U, Herrlinger U, Linnebank M, Deckert M, Fimmers R, Schmidt-Wolf IG, Schlegel U (2010) Long-term survival with favorable cognitive outcome after chemotherapy in primary central nervous system lymphoma. Ann Neurol 67:182–189CrossRefPubMed Juergens A, Pels H, Rogowski S, Fliessbach K, Glasmacher A, Engert A, Reiser M, Diehl V, Vogt-Schaden M, Egerer G, Schackert G, Reichmann H, Kroschinsky F, Bode U, Herrlinger U, Linnebank M, Deckert M, Fimmers R, Schmidt-Wolf IG, Schlegel U (2010) Long-term survival with favorable cognitive outcome after chemotherapy in primary central nervous system lymphoma. Ann Neurol 67:182–189CrossRefPubMed
7.
Zurück zum Zitat Kalfas IH, Little JR (1988) Postoperative hemorrhage: a survey of 4992 intracranial procedures. Neurosurgery 23:343–347CrossRefPubMed Kalfas IH, Little JR (1988) Postoperative hemorrhage: a survey of 4992 intracranial procedures. Neurosurgery 23:343–347CrossRefPubMed
8.
Zurück zum Zitat Leonard IE, Cunningham AJ (2002) The sitting position in neurosurgery – not yet obsolete! Br J Anaesth 88:1–3CrossRefPubMed Leonard IE, Cunningham AJ (2002) The sitting position in neurosurgery – not yet obsolete! Br J Anaesth 88:1–3CrossRefPubMed
9.
Zurück zum Zitat Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer B, Kleihues P (2007) WHO Classification of Tumours of the Central Nervous System. IARC Press, Lyon Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer B, Kleihues P (2007) WHO Classification of Tumours of the Central Nervous System. IARC Press, Lyon
10.
Zurück zum Zitat Macdonald DR, Cascino TL, Schold SC, Cairncross JG (1990) Response criteria for phase II studies of supratentorial malignant glioma. J Clin Oncol 8:1277–1280PubMed Macdonald DR, Cascino TL, Schold SC, Cairncross JG (1990) Response criteria for phase II studies of supratentorial malignant glioma. J Clin Oncol 8:1277–1280PubMed
11.
Zurück zum Zitat Sawaya R, Hammoud M, Schoppa D, Hess KR, Wu SZ, Shi WM, Wildrick DM (1998) Neurosurgical outcomes in a modern series of 400 craniotomies for treatment of parenchymal tumors. Neurosurgery 42:1044–1055CrossRefPubMed Sawaya R, Hammoud M, Schoppa D, Hess KR, Wu SZ, Shi WM, Wildrick DM (1998) Neurosurgical outcomes in a modern series of 400 craniotomies for treatment of parenchymal tumors. Neurosurgery 42:1044–1055CrossRefPubMed
12.
Zurück zum Zitat Stummer W, Pichlmeier U, Meinel T, Wiestler O, Zanella F, Reulen R (2006) Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncology 7:392–401 (for the ALA-Glioma Study Group)CrossRefPubMed Stummer W, Pichlmeier U, Meinel T, Wiestler O, Zanella F, Reulen R (2006) Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncology 7:392–401 (for the ALA-Glioma Study Group)CrossRefPubMed
13.
Zurück zum Zitat Weller M, Martus P, Roth P, Thiel E, Korfel A (2012) Surgery for primary CNS lymphoma? Challenging a paradigm. Neuro-Oncology 14:1481–1484 (for the German PCNSL Study Group)CrossRefPubMedPubMedCentral Weller M, Martus P, Roth P, Thiel E, Korfel A (2012) Surgery for primary CNS lymphoma? Challenging a paradigm. Neuro-Oncology 14:1481–1484 (for the German PCNSL Study Group)CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Weller M, Stupp R, Wick W (2012) Epilepsy meets cancer: when, why, and what to do about it? Lancet Oncol 13:e375–e382CrossRefPubMed Weller M, Stupp R, Wick W (2012) Epilepsy meets cancer: when, why, and what to do about it? Lancet Oncol 13:e375–e382CrossRefPubMed
15.
Zurück zum Zitat Wen PY, Macdonald DR, Reardon DA, Cloughesy TF, Sorensen AG, Galanis E, De Groot J, Wick W, Gilbert MR, Lassman AB, Tsien C, Mikkelsen T, Wong ET, Chamberlain MC, Stupp R, Lamborn KR, Vogelbaum MA, van den Bent MJ, Chang SM (2010) Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group. J Clin Oncol 28 1963–1972 28:1963–1972CrossRef Wen PY, Macdonald DR, Reardon DA, Cloughesy TF, Sorensen AG, Galanis E, De Groot J, Wick W, Gilbert MR, Lassman AB, Tsien C, Mikkelsen T, Wong ET, Chamberlain MC, Stupp R, Lamborn KR, Vogelbaum MA, van den Bent MJ, Chang SM (2010) Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group. J Clin Oncol 28 1963–1972 28:1963–1972CrossRef
16.
Zurück zum Zitat Andrews DW, Scott CB, Sperduto PW, Flanders AE, Gaspar LE, Schell MC, Werner-Wasik M, Demas W, Ryu J, Bahary JP, Souhami L, Rotman M, Mehta MP, Curran WJ Jr. (2004) Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet 363:1665–1672CrossRefPubMed Andrews DW, Scott CB, Sperduto PW, Flanders AE, Gaspar LE, Schell MC, Werner-Wasik M, Demas W, Ryu J, Bahary JP, Souhami L, Rotman M, Mehta MP, Curran WJ Jr. (2004) Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet 363:1665–1672CrossRefPubMed
17.
Zurück zum Zitat Maranzano E, Bellavita R, Rossi R, De Angelis V, Frattegiani A, Bagnoli R, Mignogna M, Beneventi S, Lupattelli M, Ponticelli P, Biti GP, Latini P (2005) Short-course versus split-course radiotherapy in metastaticspinal cord compression. Results of a phase III, randomized, multicenter trial. J Clin Oncol 23:3358–3365CrossRefPubMed Maranzano E, Bellavita R, Rossi R, De Angelis V, Frattegiani A, Bagnoli R, Mignogna M, Beneventi S, Lupattelli M, Ponticelli P, Biti GP, Latini P (2005) Short-course versus split-course radiotherapy in metastaticspinal cord compression. Results of a phase III, randomized, multicenter trial. J Clin Oncol 23:3358–3365CrossRefPubMed
18.
Zurück zum Zitat Deutsche Gesellschaft für Neurologie, Diener HC, Weimar C, Berlit P, Deuschl G, Elger C, Gold R, Hacke W, Hufschmidt A, Mattle H, Meier U, Oertel WH, Reichmann H, Schmutzhard E, Wallesch CW, Weller M (Hrsg) (2012) Leitlinien für Diagnostik und Therapie in der Neurologie. Metastasen und Meningeosis neoplastica. Thieme, Stuttgart, S 941–958 Deutsche Gesellschaft für Neurologie, Diener HC, Weimar C, Berlit P, Deuschl G, Elger C, Gold R, Hacke W, Hufschmidt A, Mattle H, Meier U, Oertel WH, Reichmann H, Schmutzhard E, Wallesch CW, Weller M (Hrsg) (2012) Leitlinien für Diagnostik und Therapie in der Neurologie. Metastasen und Meningeosis neoplastica. Thieme, Stuttgart, S 941–958
19.
Zurück zum Zitat Kocher M, Soffietti R, Abacioglu U, Villà S, Fauchon F, Baumert B, Fariselli L, Tzuk-Shina T, Kortmann R-D, Carrie C, Ben Hassel M, Kouri M, Valeinis E, van den Berge D, Collette S, Collete L, Mueller RP (2011) Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: Results of the EORTC 22952–26001 Study. J Clin Oncol 29:134–141CrossRefPubMed Kocher M, Soffietti R, Abacioglu U, Villà S, Fauchon F, Baumert B, Fariselli L, Tzuk-Shina T, Kortmann R-D, Carrie C, Ben Hassel M, Kouri M, Valeinis E, van den Berge D, Collette S, Collete L, Mueller RP (2011) Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: Results of the EORTC 22952–26001 Study. J Clin Oncol 29:134–141CrossRefPubMed
20.
Zurück zum Zitat Mintz AH, Kestle J, Rathbone MP, Gaspar L, Hugenholtz H, Fisher B, Duncan G, Skingley P, Foster G, Levine M (1996) A randomized trial to assess the efficacy of surgery in addition to radiotherapy in patients with a single cerebral metastasis. Cancer 78:1470–1476CrossRefPubMed Mintz AH, Kestle J, Rathbone MP, Gaspar L, Hugenholtz H, Fisher B, Duncan G, Skingley P, Foster G, Levine M (1996) A randomized trial to assess the efficacy of surgery in addition to radiotherapy in patients with a single cerebral metastasis. Cancer 78:1470–1476CrossRefPubMed
21.
Zurück zum Zitat Obbens EAMT, Leavens ME, Beal JW, Lee Y (1985) Ommaya reservoir in 387 cancer patients: a 15-year experience. Neurology 35:1274–1278CrossRefPubMed Obbens EAMT, Leavens ME, Beal JW, Lee Y (1985) Ommaya reservoir in 387 cancer patients: a 15-year experience. Neurology 35:1274–1278CrossRefPubMed
22.
Zurück zum Zitat Patchell RA, Tibbs PA, Walsh JW, Dempsey RJ, Maruyama Y, Kryscio RJ, Markesbery WR, Macdonald JS, Young B (1990) A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med 322:494–500CrossRefPubMed Patchell RA, Tibbs PA, Walsh JW, Dempsey RJ, Maruyama Y, Kryscio RJ, Markesbery WR, Macdonald JS, Young B (1990) A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med 322:494–500CrossRefPubMed
23.
Zurück zum Zitat Patchell RA, Tibbs PA, Regine WF, Dempsey RJ, Mohiuddin M, Kryscio RJ, Markesbery WR, Foon KA, Young B (1998) Postoperative radiotherapy in the treatment of single metastases to the brain. A randomized trial. J Am Med Assoc 280:1485–1489CrossRef Patchell RA, Tibbs PA, Regine WF, Dempsey RJ, Mohiuddin M, Kryscio RJ, Markesbery WR, Foon KA, Young B (1998) Postoperative radiotherapy in the treatment of single metastases to the brain. A randomized trial. J Am Med Assoc 280:1485–1489CrossRef
24.
Zurück zum Zitat Patchell RA, Tibbs PA, Regine WF, Payne R, Saris S, Kryscio RJ, Mohiuddin M, Young B (2005) Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer. A randomized trial. Lancet 366:643–648CrossRefPubMed Patchell RA, Tibbs PA, Regine WF, Payne R, Saris S, Kryscio RJ, Mohiuddin M, Young B (2005) Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer. A randomized trial. Lancet 366:643–648CrossRefPubMed
25.
Zurück zum Zitat Schellinger PD, Meinck HM, Thron A (1999) Diagnostic reach of mri compared to cct in patients with brain metastases. J Neuro-Oncol 44:275–281CrossRef Schellinger PD, Meinck HM, Thron A (1999) Diagnostic reach of mri compared to cct in patients with brain metastases. J Neuro-Oncol 44:275–281CrossRef
26.
Zurück zum Zitat Shaw EG, Scott C, Souhami L, Dinapoli R, Kline R, Loeffler J, Farnan N (2000) Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90–05. Int J Radiat Oncol Biol Phys 47:291–298CrossRefPubMed Shaw EG, Scott C, Souhami L, Dinapoli R, Kline R, Loeffler J, Farnan N (2000) Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90–05. Int J Radiat Oncol Biol Phys 47:291–298CrossRefPubMed
27.
Zurück zum Zitat Vecht CJ, Haaxma-Reiche H, Noordijk EM, Padberg GW, Voormolen JHC, Hoekstra FH, Tans JTJ, Lambooij N, Metsaars JAL, Wattendorff AR, Brand R, Hermans J (1993) Treatment of single brain metastasis: radiotherapy alone or combined with neurosurgery? Ann Neurol 33:583–590CrossRefPubMed Vecht CJ, Haaxma-Reiche H, Noordijk EM, Padberg GW, Voormolen JHC, Hoekstra FH, Tans JTJ, Lambooij N, Metsaars JAL, Wattendorff AR, Brand R, Hermans J (1993) Treatment of single brain metastasis: radiotherapy alone or combined with neurosurgery? Ann Neurol 33:583–590CrossRefPubMed
Metadaten
Titel
Hirntumoren
verfasst von
Michael Weller, Prof. Dr.
Uwe Schlegel, Prof. Dr.
Kirsten Schmieder, Prof. Dr.
Copyright-Jahr
2015
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-662-46500-4_34

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