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Erschienen in: Archives of Virology 11/2018

31.07.2018 | Original Article

Histamine contributes to severe pneumonia in pigs infected with 2009 pandemic H1N1 influenza virus

verfasst von: Yunyueng Jang, Myongha Jin, Sang Heui Seo

Erschienen in: Archives of Virology | Ausgabe 11/2018

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Abstract

Histamine is a biogenic amine that influences many immune cells. In this study, we investigated the effect of histamine on the pathogenesis of 2009 pandemic H1N1 influenza virus in pigs. Histamine was not detected in the tracheal tissues of infected pigs, and no difference was found in the pathological damage found in infected pigs with and without treatment with a histamine antagonist. Lung tissues from untreated infected pigs showed severe interstitial pneumonia with accumulation of histamine, in contrast to those from infected pigs that were treated with the histamine antagonist. The expression of inflammatory cytokines was much higher in the lungs of untreated infected pigs than in infected pigs treated with the histamine antagonist. These data suggest that histamine necessary for the development of the severe pneumonia in infected pigs.
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Metadaten
Titel
Histamine contributes to severe pneumonia in pigs infected with 2009 pandemic H1N1 influenza virus
verfasst von
Yunyueng Jang
Myongha Jin
Sang Heui Seo
Publikationsdatum
31.07.2018
Verlag
Springer Vienna
Erschienen in
Archives of Virology / Ausgabe 11/2018
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-018-3973-9

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