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Japanese Journal of Radiology

Erschienen in:

12.08.2016 | Original Article

Histogram analysis of apparent diffusion coefficients after neoadjuvant chemotherapy in breast cancer

verfasst von: Yun Ju Kim, Sung Hun Kim, Ah Won Lee, Min-Sun Jin, Bong Joo Kang, Byung Joo Song

Erschienen in: Japanese Journal of Radiology | Ausgabe 10/2016

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Abstract

Purpose

To evaluate the changes in the apparent diffusion coefficient (ADC) histogram during neoadjuvant chemotherapy (NAC) for breast cancer, and to compare the observed changes in pathologically verified responders and non-responders.

Materials and methods

Sixty-two patients received NAC followed by surgery. Responders were defined by a tumor cell reduction of at least 30 % using the Miller–Payne grading system. All the patients underwent 3T magnetic resonance with diffusion-weighted imaging (b values of 0 and 750 s/mm²) before the NAC and after the completion of two cycles of NAC.

Results

Mean, minimum, 10th, 25th, 50th, and 75th percentile of ADCs significantly increased after NAC and maximum ADC significantly decreased. Skewness became less positive and kurtosis decreased. A tendential, although not statistically significant, higher increase in mean, minimum, 10th, 25th, 50th, 75th, and 90th percentiles of ADCs was observed in responders in comparison with non-responders.

Conclusion

ADC histogram analysis quantitatively demonstrates the alterations during the treatment course.

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Titel: Histogram analysis of apparent diffusion coefficients after neoadjuvant chemotherapy in breast cancer
verfasst von: Yun Ju Kim
Sung Hun Kim
Ah Won Lee
Min-Sun Jin
Bong Joo Kang
Byung Joo Song
Publikationsdatum: 12.08.2016
Verlag: Springer Japan
Erschienen in: Japanese Journal of Radiology / Ausgabe 10/2016
Print ISSN: 1867-1071
Elektronische ISSN: 1867-108X
DOI: https://doi.org/10.1007/s11604-016-0570-2

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Histogram analysis of apparent diffusion coefficients after neoadjuvant chemotherapy in breast cancer

Abstract

Purpose

Materials and methods

Results

Conclusion

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Abstract

Purpose

Materials and methods

Results

Conclusion

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