Skip to main content
main-content

04.01.2019 | Brief Reports | Ausgabe 3/2019

Virchows Archiv 3/2019

Histological characteristics of eosinophilic myenteric ganglionitis: an under-recognised cause of chronic intestinal pseudo-obstruction

Zeitschrift:
Virchows Archiv > Ausgabe 3/2019
Autoren:
Yoichi Akazawa, Takuo Hayashi, Tsuyoshi Saito, Koichiro Niwa, Hirohiko Kamiyama, Noriko Sasahara, Kazuhiro Sakamoto, Akihito Nagahara, Takashi Yao
Wichtige Hinweise

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Abstract

Eosinophilic myenteric ganglionitis (EMG) is characterised by eosinophilic infiltration of the myenteric plexus. EMG has been rarely reported as a cause of chronic intestinal pseudo-obstruction (CIPO), and its histopathological features are not fully elucidated. We analysed seven patients with CIPO. Three of them were diagnosed with EMG and four patients were categorised as non-EMG. Clinicopathological features were similar in both groups. These features included subtle to mild lymphocytic infiltration at the myenteric ganglia/muscularis propria, loss of myenteric ganglions and interstitial cells of Cajal (ICC), and no significant findings in the mucosa. The exceptions were moderate to severe degree of eosinophilic infiltration at the myenteric ganglia/muscularis propria in EMG. Functional gastrointestinal obstruction may be associated with inflammatory cell infiltration at the myenteric ganglia/muscularis propria, leading to subsequent hypoganglionosis and deficiency of ICC in EMG. Pathologists and clinicians should be aware of this distinction during differential diagnosis of patients with CIPO.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de.

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 3/2019

Virchows Archiv 3/2019 Zur Ausgabe

Neu im Fachgebiet Pathologie

10.07.2020 | Erkrankungen durch Umwelteinflüsse | CME | Ausgabe 4/2020

Blitzunfall

Teil 1: Physikalische und epidemiologische Aspekte, Energieübertragung und Schädigungen nach überlebten Ereignissen

15.06.2020 | Dermatologische Diagnostik | Schwerpunkt: Diagnose entzündlicher Dermatosen | Ausgabe 4/2020

Moderne Diagnostik bullöser Autoimmundermatosen

04.06.2020 | Alopezie | Schwerpunkt: Diagnose entzündlicher Dermatosen | Ausgabe 4/2020

Alopezien – kühlen Kopf bewahren!