Background
Methods
Patient population
Transbronchial biopsy and computed tomography-guided fine needle biopsy procedures
Statistical analysis
Results
Case report
Patient characteristics
Variable | Number | % |
---|---|---|
Age, mean ± SD | 69.0 ± 10.2 | |
Sex | ||
Male | 159 | 70.7 |
Female | 66 | 29.3 |
Histology | ||
Adenocarcinoma | 139 | 61.5 |
Squamous cell | 67 | 30.1 |
NSCLC-NOS | 10 | 4.4 |
Pleomorphic | 5 | 2.2 |
Adenosquamous | 4 | 1.8 |
Pathological stage | ||
IA | 78 | 34.5 |
IB | 53 | 23.9 |
IIA | 23 | 10.2 |
IIB | 24 | 10.6 |
IIIA | 36 | 15.9 |
IIIB/IV | 11 | 4.9 |
Sensitivity of preoperative diagnosis for the detection of NSCLC
Preoperative diagnosis | Postoperative diagnosis | |||||
---|---|---|---|---|---|---|
ADC | SQC | NSCLC-NOS | ASC | PLE | Total | |
Malignant | ||||||
ADC | 105 | 3 | 2 | 3 | 2 | 115 |
SQC | 44 | 1 | 45 | |||
NSCLC-NOS | 2 | 1 | 4 | 7 | ||
PLE | 2 | 2 | ||||
Suspicious of NSCLC | 5 | 7 | 1 | 13 | ||
Not malignant | 27 | 12 | 3 | 1 | 43 | |
Total | 139 | 67 | 10 | 4 | 5 | 225 |
Sensitivity | Specificity | PPV | NPV | Accuracy | |
---|---|---|---|---|---|
(%) | (%) | (%) | (%) | (%) | |
Lung cancer
| 75.1 | - | 100 | 100 | 75.1 |
(169/225) | (169/169) | (56/56) | (169/225) | ||
ADC | 75.5 | 88.3 | 91.0 | 69.0 | 80.4 |
(105/139) | (76/86) | (105/115) | (76/110) | (181/225) | |
SQC | 65.6 | 99.3 | 97.7 | 87.2 | 89.3 |
(44/67) | (157/158) | (44/45) | (157/180) | (201/225) | |
p-value (ADC vs. SQC) | 0.138 | <0.001 | 0.184 | <0.001 | 0.012 |
Comparison of H&E stain vs. IHC for subtyping NSCLC
Preoperative diagnosis | ||||||||
---|---|---|---|---|---|---|---|---|
Postoperative diagnosis | H&E diagnosis | IHC predicted phenotype | ||||||
ADC | SQC | Unclassified | Total | ADC | SQC | Unclassified | Total | |
ADC | 79 | 28 | 107 | 26 | 26 | |||
SQC | 2 | 40 | 6 | 48 | 1 | 3 | 4 | |
Unclassified | 5 | 2 | 7 | 14 | 2 | 3 | 5 | |
Total | 86 | 42 | 41 | 169 | 29 | 3 | 3 | 35 |
Comparison of TBB vs. CTNB for the sensitivity or concordance of lung cancer diagnosis
Histological diagnosis | |||||||
---|---|---|---|---|---|---|---|
Lung cancer | Suspicious of malignancy | No malignancy | Sensitivity | p-value | Concordance | p-value | |
TBB | 140 | 13 | 37 | 73.2 (140/190) | 0.249 | 66.8 (127/190) | 0.594 |
CTNB | 29 | 0 | 6 | 82.9 (29/35) | 71.4 (25/35) | ||
Total | 169 | 13 | 43 | 75.0 (169/225) | 67.6 (152/225) |
Comparison of the sensitivity or concordance rate of the histological type between preoperative and surgical specimens in relation to the tumor size
Histological diagnosis | |||||||
---|---|---|---|---|---|---|---|
Lung cancer | Suspicious of malignancy | No malignancy | Sensitivity | p-value | Concordance | p-value | |
<=2 cm | 30 | 0 | 19 | 61.2 (30/49) | 0.011 | 57.1 (28/49) | 0.078 |
>2 cm | 139 | 13 | 24 | 78.9 (139/176) | 70.4 (124/176) | ||
Total | 169 | 13 | 43 | 75.0 (169/225) | 67.6 (152/225) |