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01.12.2013 | Review Article

Histology of the vaginal wall in women with pelvic organ prolapse: a literature review

verfasst von: Laurent De Landsheere, Carine Munaut, Betty Nusgens, Catherine Maillard, Chrystèle Rubod, Michelle Nisolle, Michel Cosson, Jean-Michel Foidart

Erschienen in: International Urogynecology Journal | Ausgabe 12/2013

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Abstract

Introduction and hypothesis

The pathophysiology of pelvic organ prolapse (POP) is incompletely understood. The purpose of this study is to describe the current knowledge about histology of the vaginal wall and its possible involvement in the pathogenesis of pelvic organ prolapse.

Methods

Eligible studies were selected through a MEDLINE search covering January 1986 to December 2012. The research was limited to English-language publications.

Results

Investigations of changes in the vaginal tissue that occur in women with genital prolapse are currently still limited and produced contrary results. The heterogeneity of the patients and the control groups in terms of age, parity and hormonal status, of the localization of biopsies and the histological methods as well as the lack of validation of the quantification procedures do not allow clear and definitive conclusions to be drawn.

Conclusions

This review shows that current knowledge of the histological changes observed in women with POP are inconclusive and relatively limited. More studies are needed in this specific field to better understand the mechanisms that lead to POP.

Bump RC, Norton PA (1998) Epidemiology and natural history of pelvic floor dysfunction. Obstet Gynecol Clin North Am 25:723–746PubMedCrossRef

Olsen AL, Smith VJ, Bergstrom JO et al (1997) Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence. Obstet Gynecol 89:501–506PubMedCrossRef

DeLancey JO (1992) Anatomic aspects of vaginal eversion after hysterectomy. Am J Obstet Gynecol 166:1717–1724, discussion 1724–1718PubMedCrossRef

Farrell SA, Dempsey T, Geldenhuys L (2001) Histologic examination of “fascia” used in colporrhaphy. Obstet Gynecol 98:794–798PubMedCrossRef

Weber AM, Walters MD (1997) Anterior vaginal prolapse: review of anatomy and techniques of surgical repair. Obstet Gynecol 89:311–318PubMedCrossRef

Boreham MK, Wai CY, Miller RT et al (2002) Morphometric analysis of smooth muscle in the anterior vaginal wall of women with pelvic organ prolapse. Am J Obstet Gynecol 187:56–63PubMedCrossRef

Myllyharju J, Kivirikko KI (2004) Collagens, modifying enzymes and their mutations in humans, flies and worms. Trends Genet 20:33–43PubMedCrossRef

Colige A, Ruggiero F, Vandenberghe I et al (2005) Domains and maturation processes that regulate the activity of ADAMTS-2, a metalloproteinase cleaving the aminopropeptide of fibrillar procollagens types I-III and V. J Biol Chem 280:34397–34408PubMedCrossRef

Bailey AJ (2001) Molecular mechanisms of ageing in connective tissues. Mech Ageing Dev 122:735–755PubMedCrossRef

10.

Birk DE, Fitch JM, Babiarz JP et al (1990) Collagen fibrillogenesis in vitro: interaction of types I and V collagen regulates fibril diameter. J Cell Sci 95(Pt 4):649–657PubMed

11.

Wenstrup RJ, Florer JB, Brunskill EW et al (2004) Type V collagen controls the initiation of collagen fibril assembly. J Biol Chem 279:53331–53337PubMedCrossRef

12.

Makinen J, Soderstrom KO, Kiilholma P, Hirvonen T (1986) Histological changes in the vaginal connective tissue of patients with and without uterine prolapse. Arch Gynecol 239:17–20PubMedCrossRef

13.

Kökçü A, Yanik F, Cetinkaya M et al (2002) Histopathological evaluation of the connective tissue of the vaginal fascia and the uterine ligaments in women with and without pelvic relaxation. Arch Gynecol Obstet 266:75–78

14.

Takano CC, Girao MJ, Sartori MG et al (2002) Analysis of collagen in parametrium and vaginal apex of women with and without uterine prolapse. Int Urogynecol J Pelvic Floor Dysfunct 13:342–345, discussion 345PubMedCrossRef

15.

Borges LF, Gutierrez PS, Marana HR, Taboga SR (2007) Picrosirius-polarization staining method as an efficient histopathological tool for collagenolysis detection in vesical prolapse lesions. Micron 38:580–583PubMedCrossRef

16.

Liapis A, Bakas P, Pafiti A et al (2001) Changes of collagen type III in female patients with genuine stress incontinence and pelvic floor prolapse. Eur J Obstet Gynecol Reprod Biol 97:76–79PubMedCrossRef

17.

Goepel C, Hefler L, Methfessel HD, Koelbl H (2003) Periurethral connective tissue status of postmenopausal women with genital prolapse with and without stress incontinence. Acta Obstet Gynecol Scand 82:659–664PubMedCrossRef

18.

Lin SY, Tee YT, Ng SC et al (2007) Changes in the extracellular matrix in the anterior vagina of women with or without prolapse. Int Urogynecol J Pelvic Floor Dysfunct 18:43–48PubMedCrossRef

19.

Moalli PA, Shand SH, Zyczynski HM et al (2005) Remodeling of vaginal connective tissue in patients with prolapse. Obstet Gynecol 106:953–963PubMedCrossRef

20.

Liu X, Zhao Y, Gao J et al (2004) Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Nat Genet 36:178–182PubMedCrossRef

21.

Budatha M, Roshanravan S, Zheng Q et al (2011) Extracellular matrix proteases contribute to progression of pelvic organ prolapse in mice and humans. J Clin Invest 121:2048–2059PubMedCrossRef

22.

Karam JA, Vazquez DV, Lin VK, Zimmern PE (2007) Elastin expression and elastic fibre width in the anterior vaginal wall of postmenopausal women with and without prolapse. BJU Int 100:346–350PubMedCrossRef

23.

Takacs P, Nassiri M, Viciana A et al (2009) Fibulin-5 expression is decreased in women with anterior vaginal wall prolapse. Int Urogynecol J Pelvic Floor Dysfunct 20:207–211PubMedCrossRef

24.

Calleja-Agius J, Brincat MP (2009) Urogenital atrophy. Climacteric 12:279–285PubMedCrossRef

25.

Tulikangas PK, Walters MD, Brainard JA, Weber AM (2001) Enterocele: is there a histologic defect? Obstet Gynecol 98:634–637PubMedCrossRef

26.

Boreham MK, Wai CY, Miller RT et al (2002) Morphometric properties of the posterior vaginal wall in women with pelvic organ prolapse. Am J Obstet Gynecol 187:1501–1508, discussion 1508–1509PubMedCrossRef

27.

Badiou W, Granier G, Bousquet PJ et al (2008) Comparative histological analysis of anterior vaginal wall in women with pelvic organ prolapse or control subjects. A pilot study. Int Urogynecol J Pelvic Floor Dysfunct 19:723–729PubMedCrossRef

28.

Takacs P, Gualtieri M, Nassiri M et al (2008) Vaginal smooth muscle cell apoptosis is increased in women with pelvic organ prolapse. Int Urogynecol J Pelvic Floor Dysfunct 19:1559–1564PubMedCrossRef

29.

Inal HA, Kaplan PB, Usta U et al (2010) Neuromuscular morphometry of the vaginal wall in women with anterior vaginal wall prolapse. Neurourol Urodyn 29:458–463PubMed

30.

Kaplan PB, Usta U, Inal HA et al (2011) Neuromuscular morphometry of the uterine ligaments and vaginal wall in women with pelvic organ prolapse. Neurourol Urodyn 30:126–132PubMedCrossRef

31.

Kannan K, McConnell A, McLeod M, Rane A (2011) Microscopic alterations of vaginal tissue in women with pelvic organ prolapse. J Obstet Gynaecol 31:250–253PubMedCrossRef

32.

Da Silva Lara LA, da Silva AR, Rosa ESJC et al (2009) Menopause leading to increased vaginal wall thickness in women with genital prolapse: impact on sexual response. J Sex Med 6:3097–3110

33.

Hollabaugh RS, Steiner MS, Dmochowski RR (2001) Neuroanatomy of the female continence complex: clinical implications. Urology 57:382–388PubMedCrossRef

34.

Sultan AH, Kamm MA, Hudson CN (1994) Pudendal nerve damage during labour: prospective study before and after childbirth. Br J Obstet Gynaecol 101:22–28PubMedCrossRef

35.

Tetzschner T, Sorensen M, Lose G, Christiansen J (1997) Pudendal nerve function during pregnancy and after delivery. Int Urogynecol J Pelvic Floor Dysfunct 8:66–68PubMedCrossRef

36.

Zhu L, Lang J, Chen J, Chen J (2004) Study on nerve fiber density in anterior vaginal epithelium for stress urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct 15:272–275PubMed

37.

Altman D, Zhang A, Falconer C (2006) Innervation of the rectovaginal wall in patients with rectocele compared to healthy controls. Neurourol Urodyn 25:776–781PubMedCrossRef

38.

Alperin M, Moalli PA (2006) Remodeling of vaginal connective tissue in patients with prolapse. Curr Opin Obstet Gynecol 18:544–550PubMedCrossRef

39.

Kerkhof MH, Hendriks L, Brolmann HA (2009) Changes in connective tissue in patients with pelvic organ prolapse–a review of the current literature. Int Urogynecol J Pelvic Floor Dysfunct 20:461–474PubMedCrossRef

Titel: Histology of the vaginal wall in women with pelvic organ prolapse: a literature review
verfasst von: Laurent De Landsheere
Carine Munaut
Betty Nusgens
Catherine Maillard
Chrystèle Rubod
Michelle Nisolle
Michel Cosson
Jean-Michel Foidart
Publikationsdatum: 01.12.2013
Verlag: Springer London
Erschienen in: International Urogynecology Journal / Ausgabe 12/2013
Print ISSN: 0937-3462
Elektronische ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-013-2111-1

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Histology of the vaginal wall in women with pelvic organ prolapse: a literature review

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

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Springer Medizin

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

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