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Erschienen in: International Journal of Hematology 3/2013

01.03.2013 | Progress in Hematology

Histone deacetylase inhibitors in the treatment for multiple myeloma

verfasst von: Teru Hideshima, Kenneth C. Anderson

Erschienen in: International Journal of Hematology | Ausgabe 3/2013

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Abstract

Histone lysine acetylation is regulated by both histone deacetylases (HDACs) and histone acetyl transferases. Inhibition of deacetylases induces hyperacetylate of target proteins and has a crucial role in the epigenetic regulation of gene expression mediating cell survival and proliferation. Therefore, HDAC inhibitors have emerged as novel therapeutic agents for cancers, including multiple myeloma (MM). Recent studies revealed that HDAC inhibitors trigger hyperacetylation of not only histones, but also non-histone proteins regulating cell growth and survival, revealing the complexity of mechanism of action of HDAC inhibitors. Many HDAC inhibitors have already shown significant anti-MM activities in preclinical studies and are under evaluation in clinical trials.
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Metadaten
Titel
Histone deacetylase inhibitors in the treatment for multiple myeloma
verfasst von
Teru Hideshima
Kenneth C. Anderson
Publikationsdatum
01.03.2013
Verlag
Springer Japan
Erschienen in
International Journal of Hematology / Ausgabe 3/2013
Print ISSN: 0925-5710
Elektronische ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-013-1290-3

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