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Erschienen in: Current HIV/AIDS Reports 6/2016

11.10.2016 | Complications of HIV and Antiretroviral Therapy (G McComsey, Section Editor)

HIV and Bone Complications: Understudied Populations and New Management Strategies

verfasst von: Michael T. Yin, Todd T. Brown

Erschienen in: Current HIV/AIDS Reports | Ausgabe 6/2016

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Abstract

The higher risk of osteoporosis and fracture associated with HIV infection and certain antiretrovirals has been well established and the need for risk stratification among older adults increasingly recognized. This review focuses upon emerging data on bone complications with HIV/HCV coinfection, in children and adolescents, and with pre-exposure prophylaxis (PrEP), as well as new management strategies to minimize the negative effects of ART on bone.
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Zurück zum Zitat Mulligan K, Glidden DV, Anderson PL, Liu A, McMahan V, Gonzales P, et al. Effects of emtricitabine/tenofovir on bone mineral density in HIV-negative persons in a randomized, double-blind, placebo-controlled trial. Clin Infect Dis. 2015;61(4):572–80. This study confirms that BMD loss from tenofovir-containing PrEP occurs during the first year after initiation, largely within the first 6 months. CrossRefPubMedPubMedCentral Mulligan K, Glidden DV, Anderson PL, Liu A, McMahan V, Gonzales P, et al. Effects of emtricitabine/tenofovir on bone mineral density in HIV-negative persons in a randomized, double-blind, placebo-controlled trial. Clin Infect Dis. 2015;61(4):572–80. This study confirms that BMD loss from tenofovir-containing PrEP occurs during the first year after initiation, largely within the first 6 months. CrossRefPubMedPubMedCentral
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Zurück zum Zitat Grant R, Mulligan K, McMahan V, Liu A, Guanira J, Chariyalertsak S, et al. Recovery of bone mineral density after stopping oral preexposure prophylaxis. In the Progam and Abstracts of CROI 2016, February 22-25, Abstract 48LB. 2016. An important study demonstrating the reversibility BMD loss associated with PrEP use. Grant R, Mulligan K, McMahan V, Liu A, Guanira J, Chariyalertsak S, et al. Recovery of bone mineral density after stopping oral preexposure prophylaxis. In the Progam and Abstracts of CROI 2016, February 22-25, Abstract 48LB. 2016. An important study demonstrating the reversibility BMD loss associated with PrEP use.
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Zurück zum Zitat McComsey GA, Kendall MA, Tebas P, Swindells S, Hogg E, Alston-Smith B, et al. Alendronate with calcium and vitamin D supplementation is safe and effective for the treatment of decreased bone mineral density in HIV. AIDS. 2007;21(18):2473–82.CrossRefPubMed McComsey GA, Kendall MA, Tebas P, Swindells S, Hogg E, Alston-Smith B, et al. Alendronate with calcium and vitamin D supplementation is safe and effective for the treatment of decreased bone mineral density in HIV. AIDS. 2007;21(18):2473–82.CrossRefPubMed
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Zurück zum Zitat Ofotokun I, Titanji K, Lahiri CD, Vunnava A, Foster A, Sanford SE, et al. A single-dose zoledronic acid infusion prevents antiretroviral therapy-induced bone loss in treatment-naive HIV-infected patients: a phase IIb trial. Clin Infect Dis. 2016;63(5):663–71. This study demonstrates that a single dose of zoledronic acid prevents bone loss associated with initiation of antiretroviral therapy; however, its role in management has not been clearly established. CrossRefPubMed Ofotokun I, Titanji K, Lahiri CD, Vunnava A, Foster A, Sanford SE, et al. A single-dose zoledronic acid infusion prevents antiretroviral therapy-induced bone loss in treatment-naive HIV-infected patients: a phase IIb trial. Clin Infect Dis. 2016;63(5):663–71. This study demonstrates that a single dose of zoledronic acid prevents bone loss associated with initiation of antiretroviral therapy; however, its role in management has not been clearly established. CrossRefPubMed
Metadaten
Titel
HIV and Bone Complications: Understudied Populations and New Management Strategies
verfasst von
Michael T. Yin
Todd T. Brown
Publikationsdatum
11.10.2016
Verlag
Springer US
Erschienen in
Current HIV/AIDS Reports / Ausgabe 6/2016
Print ISSN: 1548-3568
Elektronische ISSN: 1548-3576
DOI
https://doi.org/10.1007/s11904-016-0341-9

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