nach oben

Erschienen in:

18.07.2016 | Short Communication

HIV and decreased risk of multiple sclerosis: role of low CD4+ lymphocyte count and male prevalence

verfasst von: Tatiana Koudriavtseva, Domenico Plantone, Chiara Mandoj, Diana Giannarelli, Alessandra Latini, Manuela Colafigli, Elisabetta Trento, Paola Cordiali-Fei, Fulvia Pimpinelli

Erschienen in: Journal of NeuroVirology | Ausgabe 1/2017

Einloggen, um Zugang zu erhalten

Abstract

In this retrospective case-control study, we compared the number of circulating lymphocyte subsets among 31 healthy controls, 18 naïve and 40 antiretroviral-treated HIV patients, 28 untreated and 18 treated relapsing-remitting multiple sclerosis (MS) patients. Lymphocyte subsets were no different between untreated MS patients and controls. Untreated and treated MS had a lower CD8+ count and a higher CD4+ number compared to untreated and treated HIV patients except similar CD4+ number between treated MS and HIV patients. CD4/CD8 ratio was lower in female HIV non-responders and in relapsing MS women compared, respectively, to female HIV responders and remitting MS women, and there were no differences in men.

Alter G, Teigen N, Davis BT, Addo MM, Suscovich TJ, Waring MT, Streeck H, Johnston MN, Staller KD, Zaman MT, Yu XG, Lichterfeld M, Basgoz N, Rosenberg ES, Altfeld M (2005) Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection. Blood 106:3366–3369. doi:10.1182/blood-2005-03-1100 CrossRefPubMed

Altfeld M, Fadda L, Frleta D, Bhardwaj N (2011) DCs and NK cells: critical effectors in the immune response to HIV-1. Nat Rev Immunol 11:176–186. doi:10.1038/nri2935 CrossRefPubMedPubMedCentral

Chakrabarti LA, Simon V (2010) Immune mechanism of HIV control. Curr Opin Immunol 22:488–496. doi:10.1016/j.coi.2010.06.006 CrossRefPubMedPubMedCentral

Chin JH (2015) Multiple sclerosis and HIV-1 infection: case report of a HIV controller. J Neurovirol 21(4):464–467. doi:10.1007/s13365-015-0335-1 CrossRefPubMed

Cinque P, Bossolasco S, Brambilla AM, Boschini A, Mussini C, Pierotti C, Campi A, Casari S, Bertelli D, Mena M, Lazzarin A (2003) The effect of highly active antiretroviral therapy-induced immune reconstitution on development and outcome of progressive multifocal leukoencephalopathy: study of 43 cases with review of the literature. J Neurovirol 9(Suppl 1):73–80CrossRefPubMed

Cross AH, Waubant E (2011) MS and the B cell controversy. Biochim Biophys Acta Mol basis Dis 1812:231–238. doi:10.1016/j.bbadis.2010.07.020 CrossRef

Delgado SR, Maldonado J, Rammohan KW (2014) CNS demyelinating disorder with mixed features of neuromyelitis optica and multiple sclerosis in HIV-1 infection. Case report and literature review. J Neurovirol 20:531–537. doi:10.1007/s13365-014-0260-8 CrossRefPubMed

Frisullo G, Plantone D, Marti A, Iorio R, Nociti V, Patanella AK, Batocchi AP (2011) Circulating CD8+CD56−perforin+ T cells are increased in multiple sclerosis patients. J Neuroimmunol 240–241:137–141. doi:10.1016/j.jneuroim.2011.09.002 CrossRef

Gold J, Goldacre R, Maruszak H, Giovannoni G, Yeates D, Goldacre M (2015) HIV and lower risk of multiple sclerosis: beginning to unravel a mystery using a record-linked database study. J Neurol Neurosurg Psychiatry 86:9–12. doi:10.1136/jnnp-2014-307932 CrossRefPubMed

González-Duarte A, Ramirez C, Pinales R, Sierra-Madero J (2011) Multiple sclerosis typical clinical and MRI findings in a patient with HIV infection. J Neurovirol 17:504–508. doi:10.1007/s13365-011-0054-1 CrossRefPubMed

Jentsch-Ullrich K, Koenigsmann M, Mohren M, Franke A (2005) Lymphocyte subsets’ reference ranges in an age- and gender-balanced population of 100 healthy adults—a monocentric German study. Clin Immunol 116:192–197CrossRefPubMed

Mavilio D, Lombardo G, Benjamin J, Kim D, Follman D, Marcenaro E, O’Shea MA, Kinter A, Kovacs C, Moretta A, Fauci AS (2005) Characterization of CD56-/CD16+ natural killer (NK) cells: a highly dysfunctional NK subset expanded in HIV-infected viremic individuals. Proc Natl Acad Sci U S A 102:2886–2891. doi:10.1073/pnas.0409872102 CrossRefPubMedPubMedCentral

Morandi B, Bramanti P, Bonaccorsi I, Montalto E, Oliveri D, Pezzino G, Navarra M, Ferlazzo G (2008) Role of natural killer cells in the pathogenesis and progression of multiple sclerosis. Pharmacol Res 57:1–5. doi:10.1016/j.phrs.2007.11.003 CrossRefPubMed

Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, Filippi M, Fujihara K, Havrdova E, Hutchinson M, Kappos L, Lublin FD, Montalban X, O’Connor P, Sandberg-Wollheim M, Thompson AJ, Waubant E, Weinshenker B, Wolinsky JS (2011) Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria. Ann Neurol 69:292–302. doi:10.1002/ana.22366 CrossRefPubMedPubMedCentral

Poropatich K, Sullivan DJ (2011) Human immunodeficiency virus type 1 long-term non-progressors: the viral, genetic and immunological basis for disease non-progression. J Gen Virol 92:247–268. doi:10.1099/vir.0.027102-0 CrossRefPubMed

Schleinitz N, Vély F, Harlé JR, Vivier E (2010) Natural killer cells in human autoimmune diseases. Immunology 131:451–458. doi:10.1111/j.1365-2567.2010.03360.x CrossRefPubMedPubMedCentral

Valiathan R, Deeb K, Diamante M, Ashman M, Sachdeva N, Asthana D (2014) Reference ranges of lymphocyte subsets in healthy adults and adolescents with special mention of T cell maturation subsets in adults of South Florida. Immunobiology 219:487–496. doi:10.1016/j.imbio.2014.02.010 CrossRefPubMed

Vendrely A, Bienvenu B, Gasnault J, Thiebault JB, Salmon D, Gray F (2005) Fulminant inflammatory leukoencephalopathy associated with HAART-induced immune restoration in AIDS-related progressive multifocal leukoencephalopathy. Acta Neuropathol 109:449–455CrossRefPubMed

Zandman-Goddard G, Shoenfeld Y (2002) HIV and autoimmunity. Autoimmun Rev 1:329–337. doi:10.1016/S1568-9972(02)00086-1 CrossRefPubMed

Titel: HIV and decreased risk of multiple sclerosis: role of low CD4+ lymphocyte count and male prevalence
verfasst von: Tatiana Koudriavtseva
Domenico Plantone
Chiara Mandoj
Diana Giannarelli
Alessandra Latini
Manuela Colafigli
Elisabetta Trento
Paola Cordiali-Fei
Fulvia Pimpinelli
Publikationsdatum: 18.07.2016
Verlag: Springer International Publishing
Erschienen in: Journal of NeuroVirology / Ausgabe 1/2017
Print ISSN: 1355-0284
Elektronische ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-016-0471-2

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

18.04.2024 | Arterielle Hypertonie | Nachrichten

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

HIV and decreased risk of multiple sclerosis: role of low CD4+ lymphocyte count and male prevalence

Abstract

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

Manche Gestagene können das Risiko für Meningeome erhöhen

Parkinson: Größere Studie bestätigt Genauigkeit von Hauttest

Update Neurologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2017

Adult-onset opsoclonus-myoclonus syndrome due to West Nile Virus treated with intravenous immunoglobulin

Evaluation of practice effect on neuropsychological measures among persons with and without HIV infection in northern India

Immortalization of primary microglia: a new platform to study HIV regulation in the central nervous system

Human cytomegalovirus downregulates SLITRK6 expression through IE2

Review of functional MRI in HIV: effects of aging and medication

Evaluating the accuracy of self-report for the diagnosis of HIV-associated neurocognitive disorder (HAND): defining “symptomatic” versus “asymptomatic” HAND

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

Manche Gestagene können das Risiko für Meningeome erhöhen

Parkinson: Größere Studie bestätigt Genauigkeit von Hauttest

Update Neurologie