Background
Methods
Cohort description
HLA typing
Data analysis
Results
HLA allele groups in the general population
A*alleles | 2 N = 114 | B*allele | 2 N = 104 | C*allele | 2 N = 114 | DRB1*allele | 2 N = 186 | DQB1*allele | 2 N = 136 |
---|---|---|---|---|---|---|---|---|---|
Frequency (%) | Frequency (%) | Frequency (%) | Frequency (%) | Frequency (%) | |||||
A*01 | 14.04 | B*07 | 13.46 | C*01 | 6.14 | DRB1*01 | 2.69 | DQB1*02 | 22.06 |
A*02 | 18.42 | B*08 | 7.69 | C*02 | 35.09 | DRB1*03 | 24.73 | DQB1*03 | 36.03 |
A*03 | 3.51 | B*14 | 0.69 | C*03 | 6.14 | DRB1*04 | 4.30 | DQB1*04 | 7.35 |
A*11 | 0.88 | B*15 | 8.65 | C*04 | 0.88 | DRB1*07 | 8.06 | DQB1*05 | 18.38 |
A*23 | 14.04 | B*18 | 3.85 | C*05 | 2.63 | DRB1*08 | 4.84 | DQB1*06 | 16.18 |
A*24 | 2.63 | B*27 | 7.69 | C*06 | 13.16 | DRB1*09 | 0.54 | ||
A*26 | 2.63 | B*35 | 8.65 | C*07 | 20.18 | DRB1*10 | 6.45 | ||
A*29 | 12.28 | B*37 | 3.85 | C*08 | 3.51 | DRB1*11 | 13.98 | ||
A*30 | 13.16 | B*39 | 1.92 | C*14 | 1.75 | DRB1*12 | 0.54 | ||
A*32 | 2.63 | B*40 | 2.88 | C*15 | 0.88 | DRB1*13 | 27.42 | ||
A*33 | 3.51 | B*41 | 0.69 | C*16 | 5.26 | DRB1*14 | 2.69 | ||
A*34 | 1.75 | B*42 | 3.85 | C*17 | 3.51 | DRB1*15 | 4.00 | ||
A*36 | 0.88 | B*44 | 6.73 | C*18 | 0.88 | ||||
A*66 | 1.75 | B*45 | 4.81 | ||||||
A*69 | 0.88 | B*49 | 1.92 | ||||||
A*74 | 5.26 | B*50 | 5.77 | ||||||
A*80 | 1.75 | B*51 | 6.73 | ||||||
B*52 | 1.92 | ||||||||
B*53 | 0.69 | ||||||||
B*56 | 0.69 | ||||||||
B*57 | 0.69 | ||||||||
B*58 | 2.88 | ||||||||
B*78 | 0.69 | ||||||||
B*82 | 0.69 |
Ethnic distribution of HLA alleles
HLA-A | HLA-B | HLA-C | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Alleles | WM 2 N = 38 Frequency (%) | BM 2 N = 42 Frequency (%) | BA 2 N = 34 Frequency (%) | Alleles | WM 2 N = 36 Frequency (%) | BM 2 N = 36 Frequency (%) | BA 2 N = 32 Frequency (%) | Alleles | WM 2 N = 38 Frequency (%) | BM 2 N = 42 Frequency (%) | BA 2 N = 34 Frequency (%) |
A*01 | 10.53 | 11.9 | 20.59 | B*07 | 16.67 | 11.11 | 12.5 | C*01 | 4.76 | 14.71 | |
A*02 | 18.42 | 21.43 | 14.71 | B*08 | 11.11 | 8.33 | 3.13 | C*02 | 42.11 | 33.33 | 29.41 |
A*03 | 7.89 | 2.38 | B*14 | 2.78 | C*03 | 5.26 | 7.14 | 5.88 | |||
A*11 | 2.63 | B*15 | 2.78 | 16.67 | 6.25 | C*04 | 2.38 | ||||
A*23 | 15.79 | 14.29 | 11.76 | B*18 | 2.78 | 5.56 | 3.13 | C*05 | 2.63 | 4.76 | |
A*24 | 5.26 | 2.38 | B*27 | 5.56 | 5.56 | 12.5 | C*06 | 13.16 | 9.52 | 17.65 | |
A*26 | 4.76 | 2.94 | B*35 | 8.33 | 2.78 | 15.63 | C*07 | 28.95 | 21.43 | 8.82 | |
A*29 | 2.63 | 19.05 | 14.71 | B*37 | 2.78 | 9.38 | C*08 | 5.26 | 5.88 | ||
A*30 | 18.42 | 9.52 | 11.76 | B*39 | 5.56 | C*14 | 2.38 | 2.94 | |||
A*32 | 2.63 | 4.76 | B*40 | 5.56 | 2.78 | C*15 | 2.94 | ||||
A*33 | 2.63 | 8.82 | B*41 | 2.78 | C*16 | 9.52 | 5.88 | ||||
A*34 | 2.63 | 2.38 | B*42 | 2.78 | 2.78 | 6.25 | C*17 | 2.63 | 2.38 | 5.88 | |
A*36 | 2.63 | B*44 | 11.11 | 5.56 | 3.13 | C*18 | 2.38 | ||||
A*66 | 2.63 | 2.38 | B*45 | 5.56 | 5.56 | 3.13 | |||||
A*69 | 2.94 | B*49 | 6.25 | ||||||||
A*74 | 5.26 | 2.38 | 8.82 | B*50 | 8.33 | 8.33 | |||||
A*80 | 2.38 | 2.94 | B*51 | 5.56 | 11.11 | 3.13 | |||||
B*52 | 2.78 | 3.13 | |||||||||
B*53 | 3.13 | ||||||||||
B*56 | 3.13 | ||||||||||
B*57 | 2.78 | ||||||||||
B*58 | 5.56 | 2.78 | |||||||||
B*78 | 3.13 | ||||||||||
B*82 | 3.13 |
HLA-DRB1 | HLA-DQB1 | ||||||
---|---|---|---|---|---|---|---|
Alleles | WM 2 N = 60 Frequency (%) | BM 2 N = 68 Frequency (%) | BA 2 N = 58 Frequency (%) | Alleles | WM 2 N = 52 Frequency (%) | BM 2 N = 42 Frequency (%) | BA 2 N = 42 Frequency (%) |
DRB1*01 | 1.67 | 4.41 | 1.72 | DQB1*02 | 25 | 16.67 | 23.81 |
DRB1*03 | 26.67 | 23.53 | 24.14 | DQB1*03 | 26.92 | 42.86 | 40.48 |
DRB1*04 | 5 | 2.94 | 5.17 | DQB1*04 | 7.69 | 7.14 | 7.14 |
DRB1*07 | 6.67 | 8.82 | 8.62 | DQB1*05 | 17.31 | 19.05 | 19.05 |
DRB1*08 | 6.67 | 2.94 | 5.17 | DQB1*06 | 23.08 | 14.29 | 9.52 |
DRB1*09 | 1.67 | ||||||
DRB1*10 | 5 | 2.94 | 12.07 | ||||
DRB1*11 | 13.33 | 16.18 | 12.07 | ||||
DRB1*12 | 1.47 | ||||||
DRB1*13 | 25 | 30.88 | 25.86 | ||||
DRB1*14 | 3.33 | 4.41 | |||||
DRB1*15 | 5 | 1.47 | 5.17 |
Most frequent HLA Haplotypes
Haplotypes | HF (%) | LDx100 | RLD | Haplotypes | HF (%) | LDx100 | RLD |
---|---|---|---|---|---|---|---|
A-B | A-C | ||||||
A*02B*07 | 4.44 | 1.26 | 0.12 | A*02C*02 | 10.00 | 3.18 | 0.27 |
A*01B*07 | 3.33 | 2.03 | 0.17 | A*23C*02 | 8.88 | 2.09 | 0.23 |
A*02B*15 | 3.33 | 1.22 | 0.17 | A*01C*02 | 4.44 | 1.21 | 0.13 |
A*23B*07 | 3.33 | 0.94 | 0.08 | A*01C*06 | 4.44 | 1.66 | 0.15 |
A*23B*08 | 3.33 | 1.78 | 0.27 | A*02C*06 | 4.44 | 1.08 | 0.1 |
A*30B*50 | 3.33 | 1.14 | 0.23 | A*23C*07 | 3.33 | 1.55 | 0.14 |
A*01B*37 | 2.22 | 1.41 | 0.42 | A*30C*02 | 3.33 | −1.11 | −0.24 |
A*02B*35 | 2.22 | 0.26 | 0.04 | A*30C*07 | 3.33 | 0.85 | 0.08 |
A*02B*39 | 2.22 | 1.55 | 1 | A*02C*07 | 2.22 | −1.08 | −0.29 |
A*02B*42 | 2.22 | 1.18 | 0.38 | A*03C*07 | 2.22 | 1.04 | 0.37 |
A*23B*15 | 2.22 | 0.68 | 0.09 | A*29C*02 | 2.22 | −2.55 | −0.59 |
A*23B*27 | 2.22 | 0.81 | 0.12 | A*29C*07 | 2.22 | 0.15 | 0.02 |
A*30B*15 | 2.22 | 0.75 | 0.1 | ||||
A*30B*27 | 2.22 | 0.88 | 0.13 | DRB1-DQB1 | |||
DRB1*13DQB1*06 | 11.94 | 7.04 | 0.61 | ||||
B-C | DRB1*03DQB1*02 | 11.19 | 5.7 | 0.35 | |||
B*07C*02 | 8.88 | 3.86 | 0.44 | DRB1*03DQB1*03 | 10.45 | 1.36 | 0.08 |
B*15C*02 | 8.88 | 4.61 | 0.83 | DRB1*13DQB1*03 | 8.21 | −2.49 | −0.23 |
B*27C*02 | 5.55 | 3.03 | 0.61 | DRB1*13DQB1*05 | 6.72 | 1.15 | 0.09 |
B*35C*02 | 4.44 | 0.76 | 0.14 | DRB1*11DQB1*03 | 5.22 | 0.9 | 0.01 |
B*44C*07 | 4.44 | 2.49 | 0.46 | DRB1*07DQB1*02 | 4.48 | 3.02 | 0.57 |
B*08C*02 | 3.33 | 0.15 | 0.03 | DRB1*10DQB1*05 | 4.48 | 3.36 | 0.69 |
B*37C*06 | 3.33 | 2.33 | 0.71 | DRB1*11DQB1*02 | 3.73 | 0.18 | 0.01 |
B*40C*07 | 3.33 | 2.3 | 1 | DRB1*11DQB1*04 | 2.99 | 1.76 | 0.28 |
B*07C*06 | 2.22 | −0.09 | −0.01 | DRB1*11DQB1*05 | 2.99 | −0.08 | −0.03 |
B*07C*07 | 2.22 | 0.75 | 0.16 | DRB1*08DQB1*03 | 2.24 | 1.17 | 0.61 |
B*08C*03 | 2.22 | 0.15 | 0.23 | DRB1*13DQB1*04 | 2.24 | 0.01 | 0.01 |
B*08C*07 | 2.22 | 1.33 | 0.22 | DRB1*01DQB1*03 | 1.49 | 0.69 | 0.48 |
B*35C*01 | 2.22 | 2.37 | 0.56 | DRB1*03DQB1*05 | 1.49 | −3.25 | −0.68 |
DRB1*03DQB1*06 | 1.49 | −3.67 | −0.64 | ||||
A-DRB1 | DRB1*04DQB1*03 | 1.49 | 0.42 | 0.22 | |||
A*02DRB1*03 | 11.9 | 4.3 | 0.32 | ||||
A*01DRB1*07 | 5.95 | 3.35 | 0.48 | A-DQB1 | |||
A*23DRB1*03 | 5.95 | 1.62 | 0.15 | A*30DQB1*03 | 8.33 | 2.68 | 0.33 |
A*74DRB1*13 | 5.95 | 2.81 | 0.75 | A*02DQB1*02 | 7.14 | 3.85 | 0.26 |
A*23DRB1*13 | 4.76 | −0.99 | −0.21 | A*02DQB1*03 | 7.14 | −0.44 | −0.06 |
A*30DRB1*13 | 4.76 | 1.41 | 0.16 | A*01DQB1*02 | 5.95 | 3.06 | 0.27 |
A*02DRB1*13 | 3.57 | −2.15 | −0.37 | A*23DQB1*02 | 5.95 | 1.27 | 0.11 |
A*29DRB1*03 | 3.57 | 1.19 | 0.12 | A*23DQB1*03 | 4.76 | 1.15 | 0.12 |
A*30DRB1*11 | 3.57 | −0.03 | −0.01 | A*01DQB1*03 | 3.57 | −0.64 | −0.13 |
A*01DRB1*03 | 2.38 | −1.11 | −0.28 | A*01DQB1*05 | 3.57 | 0.25 | 0.02 |
A*01DRB1*11 | 2.38 | −0.29 | −0.14 | A*02DQB1*05 | 3.57 | −0.5 | −0.15 |
A*03DRB1*13 | 2.38 | 0.66 | 0.26 | A*29DQB1*06 | 3.57 | 1.34 | 0.13 |
A*23DRB1*15 | 2.38 | 2.19 | 0.71 | A*74DQB1*03 | 3.57 | 0.76 | 0.22 |
A*29DRB1*11 | 2.38 | 0.87 | 0.08 | A*23DQB1*05 | 2.38 | −0.63 | −0.26 |
A*30DRB1*03 | 2.38 | −1.53 | −0.45 | A*23DQB1*06 | 2.38 | −0.76 | −0.3 |
A*30DRB1*10 | 2.38 | 1.24 | 0.31 | A*29DQB1*04 | 2.38 | 1.78 | 0.28 |
A*34DRB1*13 | 2.38 | 0.33 | 0.26 | A*30DQB1*04 | 2.38 | 0.89 | 0.14 |
A*66DRB1*13 | 2.38 | 1.24 | 1 | A*30DQB1*05 | 2.38 | −0.33 | −0.15 |
C-DRB1 | |||||||
B-DRB1 | C*02DRB1*03 | 16.67 | 4.29 | 0.25 | |||
B*07DRB1*03 | 5.95 | 1.51 | 0.18 | C*07DRB1*13 | 9.52 | 1.81 | 0.13 |
B*15DRB1*03 | 5.95 | 2.86 | 0.49 | C*02DRB1*11 | 4.76 | −0.61 | −0.12 |
B*50DRB1*13 | 4.76 | 2.08 | 0.5 | C*02DRB1*13 | 4.76 | −4.92 | −0.43 |
B*08DRB1*03 | 3.57 | 1.84 | 0.31 | C*03DRB1*13 | 4.76 | 1.61 | 0.37 |
B*27DRB1*13 | 3.57 | 1.44 | 0.26 | C*02DRB1*08 | 3.57 | 1.76 | 1 |
B*37DRB1*07 | 3.57 | 2.64 | 0.72 | C*06DRB1*03 | 3.57 | −0.63 | −0.19 |
B*40DRB1*13 | 3.57 | 2.04 | 1 | C*06DRB1*07 | 3.57 | 1.69 | 0.24 |
B*44DRB1*13 | 3.57 | 2.08 | 0.5 | C*06DRB1*13 | 3.57 | 0.5 | 0.06 |
B*50DRB1*13 | 3.57 | 2.08 | 0.51 | C*07DRB1*11 | 3.57 | −0.61 | −0.12 |
B*07DRB1*08 | 2.38 | 1.61 | 0.61 | C*08DRB1*13 | 3.57 | 2.48 | 1 |
B*08DRB1*11 | 2.38 | 0.88 | 0.12 | C*02DRB1*10 | 2.38 | 0.2 | 0.07 |
B*08DRB1*13 | 2.38 | −0.56 | −0.21 | C*05DRB1*07 | 2.38 | 1.59 | 0.63 |
B*18DRB1*03 | 2.38 | 0.92 | 0.31 | C*06DRB1*11 | 2.38 | −0.94 | −0.5 |
B*35DRB1*03 | 2.38 | −0.09 | −0.03 | C*07DRB1*03 | 2.38 | −2.54 | −0.48 |
Haplotypes | Frequency (%) | Haplotypes | Frequency (%) |
---|---|---|---|
A- B -C | A- B -DRB1 | ||
A*02B*07C*02 | 3.33 | A*02B*07DRB1*03 | 4.76 |
A*02B*15C*02 | 3.33 | A*01B*37DRB1*07 | 2.38 |
A*23B*08C*02 | 3.33 | A*02B*39DRB1*03 | 2.38 |
A*01B*07C*02 | 2.22 | A- B- C-DRB1 | |
A*01B*37C*06 | 2.22 | A*02B*07C*02DRB1*03 | 3.57 |
A*02B*35C*02 | 2.22 | A*01B*37C*06DRB1*07 | 2.38 |
A*02B*39C*06 | 2.22 | A*02B*39C*06DRB1*03 | 2.38 |
A*23B*15C*02 | 2.22 | A*23B*08C*02DRB1*03 | 2.38 |
A*23B*27C*02 | 2.22 | A*23B*08DRB1*03 | 2.38 |
A*30B*15DRB1*03 | 2.38 | ||
A*30B*50DRB1*13 | 2.38 | ||
A B C DQB1 | |||
A*02B*07C*02DQB1*02 | 2.38% | ||
A*02B*15C*02DQB1*03 | 2.38% | ||
A*23B*08C*02DQB1*02 | 2.38% 2.38% | ||
A*23B*15C*02DQB1*0 | |||
A B C DRB1 DQB1 | |||
A*02B*07C*02DRB1*03DQB1*02 | 2.38% | ||
A*23B*08C*02DRB1*03DQB1*02 | 2.38% | ||
A*01B*07C*02DRB1*01DQB1*05 | 1.19% | ||
A*01B*07C*02DRB1*08DQB1*03 | 1.19% |