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Hormones and Cancer

Hormones and Cancer OnlineFirst articles

10.02.2020 | Original Paper

Estradiol-Induced MMP-9 Expression via PELP1-Mediated Membrane-Initiated Signaling in ERα-Positive Breast Cancer Cells

Proline-, glutamic acid–, leucine-rich protein 1 (PELP1) is a novel estrogen receptor (ER) coregulator, demonstrated distinctive characters from other ERα coregulators, and has been suggested to be involved in metastasis of several cancers. In …


Progesterone and Breast Cancer: an NCI Workshop Report

PR isoforms have different binding sites in chromatin, and the coregulators associated with PR isoforms are different ( 1 ); more recent studies have expanded the repertoire of isoform-specific PR binding partners as measured by Rapid …

01.02.2020 | Original Paper

Cytoplasmic ERα and NFκB Promote Cell Survival in Mouse Mammary Cancer Cell Lines

There is a desperate need in the field for mouse mammary tumors and cell lines that faithfully mimic estrogen receptor (ER) expression and activity found in human breast cancers. We found that several mouse mammary cancer cell lines express ER but …

30.01.2020 | Original Paper

Molecular and Electrophysiological Analyses of ATP2B4 Gene Variants in Bilateral Adrenal Hyperaldosteronism

Primary aldosteronism (PA) is the most common cause of secondary hypertension with a high prevalence among patients with resistant hypertension. Despite the recent discovery of somatic variants in aldosterone-producing adenoma (APA)-associated PA …

16.01.2020 | Original Paper

Progesterone Receptor Gene Variants in Metastatic Estrogen Receptor Positive Breast Cancer

Tumor mutations in the gene encoding estrogen receptor alpha (ESR1) have been identified in metastatic breast cancer patients with endocrine therapy resistance. However, relatively little is known about the occurrence of mutations in the …

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Über diese Zeitschrift

Major areas of interest in cancer biology include:

-Cancer causation, metabolism, and hormone-dependence

-Disease progression, prevention, treatment, and resistance

-Translational studies dealing with novel therapeutic agents

-Hormone receptors and their co-regulatory molecules

-Hormonally infl uenced signaling pathways

-Nuclear and Steroid Hormone Receptors

-Adrenal, pituitary, and thyroid hormones

-Vitamin D

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