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Breast Cancer Research

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01.06.2003 | Review

Host microenvironment in breast cancer development: Extracellular matrix–stromal cell contribution to neoplastic phenotype of epithelial cells in the breast

verfasst von: Malathy PV Shekhar, Robert Pauley, Gloria Heppner

Erschienen in: Breast Cancer Research | Ausgabe 3/2003

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Abstract

Epithelial–mesenchymal interactions play an important role both in normal mammary gland development and during neoplastic transformation. Perturbations in the production, deposition and degradation of the extracellular matrix occurring during neoplastic transformation and progression have been implicated to arise from alterations in the stromal response. These changes in the stroma exhibit a dominant regulatory role, via microenvironmental epigenetic effectors, to contribute to the development of the tumorigenic epithelial phenotype. The role of stromally derived microenvironmental epigenetic effectors in modulating epithelial growth, hormonal response, morphogenesis and epithelial plasticity is discussed.

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Titel: Host microenvironment in breast cancer development: Extracellular matrix–stromal cell contribution to neoplastic phenotype of epithelial cells in the breast
verfasst von: Malathy PV Shekhar
Robert Pauley
Gloria Heppner
Publikationsdatum: 01.06.2003
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe 3/2003
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr580

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