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Erschienen in: Indian Journal of Pediatrics 4/2019

12.01.2019 | Original Article

How Different is AMAN from AIDP in Childhood GBS? A Prospective Study from North India

verfasst von: Pradeep Kumar Gupta, Pratibha Singhi, Sunit Singhi, Ananthanarayanan Kasinathan, Naveen Sankhyan

Erschienen in: Indian Journal of Pediatrics | Ausgabe 4/2019

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Abstract

Objectives

To compare the clinical profile and short-term outcome of children with axonal and demyelinating subtypes of childhood Guillain Barré syndrome (GBS).

Methods

This is a prospective observational study conducted in a tertiary care teaching hospital in North India. Consecutive children with Guillain Barré syndrome were recruited to compare the clinical profile and short term outcome among the subtypes.

Results

Among 9847 children admitted to the emergency, 95 had acute flaccid paralysis; 57 of whom had GBS. Electrophysiological studies were completed in 57; of whom 20 had acute inflammatory demyelinating polyneuropathy (AIDP); 19 had acute motor axonal neuropathy (AMAN); 12 had non-reactive nerves; five were unclassifiable; 1 had acute motor sensory axonal neuropathy (AMSAN). More children in AMAN group had preceding gastroenteritis (4 vs. 2), while AIDP group had upper respiratory infections (12 vs. 7). Ataxia was only seen in AIDP subtype while wrist drop, foot drop and hyperreflexia were seen only with AMAN subtype. Respiratory muscle involvement (6 vs. 3) and artificial ventilation (5 vs. 2) was more in AMAN. At discharge, children with AIDP were less likely to be non-ambulant (12 vs. 6, p = 0.036). Mean disability scores at hospital discharge (4.9 ± 1.2 vs. 4 ± 0.9, p = 0.015) and at last follow-up (0.7 ± 1.01 vs. 0.05 ± 0.2, p = 0.016) were higher in AMAN. Children with AIDP were more likely to achieve normalcy on follow-up (19 vs. 12, p = 0.023).

Conclusions

Children with AMAN appear to have a more severe clinical course; higher short-term morbidity; and slower recovery than those with AIDP.
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Metadaten
Titel
How Different is AMAN from AIDP in Childhood GBS? A Prospective Study from North India
verfasst von
Pradeep Kumar Gupta
Pratibha Singhi
Sunit Singhi
Ananthanarayanan Kasinathan
Naveen Sankhyan
Publikationsdatum
12.01.2019
Verlag
Springer India
Erschienen in
Indian Journal of Pediatrics / Ausgabe 4/2019
Print ISSN: 0019-5456
Elektronische ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-018-2835-5

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