Introduction
Methods
Systematic literature research
Author | Year | Orign | Plants investigated | |
---|---|---|---|---|
Ghorbani et al. (2018) | 2018 | Iran | Camellia sinensis KUNTZE | |
Moriyama et al. (2018) | 2018 | Japan | Glycyrrhiza glabra L. Rheum L. Zingiber officinale ROSCOE | |
Nishikawa et al. (2018) | 2018 | Japan | Zingiber officinale ROSCOE | |
Kato et al. (2017) | 2017 | Japan | Zingiber officinale ROSCOE Matricaria recutita L. | |
Dos Reis et al. (2016) | 2016 | Brazil | Matricaria recutita L. | |
Nasry et al. (2016) | 2016 | Egypt | Glycyrrhiza glabra L. Acacia nilotica. J.H. Hurter & Mabb | |
Tavakoli Ardakani et al. (2016) | 2016 | Iran | Matricaria recutita L. Mentha × piperita L. | |
Mutluay Yayla et al. (2016) | 2016 | Turkey | Salvia officinalis L. Mentha × piperita L. Thymus serpyllum | |
Braga et al. (2015) | 2015 | Brazil | Matricaria recutita L. | |
Haghpanah et al. (2015) | 2015 | Iran | Zingiber officinale ROSCOE | |
Matsuda et al. (2015) | 2015 | Japan | Zingiber officinale ROSCOE | |
Hatakeyama et al. (2015) | 2015 | Japan | Zingiber officinale ROSCOE | |
Miranzadeh et al. (2015) | 2015 | Iran | Achillea millefolium L. | |
Andishe Tadbir et al. (2015) | 2015 | Iran | Matricaria recutita L. | |
Yamashita et al. (2015) | 2015 | Japan | Zingiber officinale ROSCOE | |
Seyyedi et al. (2014) | 2014 | Iran | Matricaria recutita L. | |
Gavanji et al. (2014) | 2014 | Iran | Punica granatum L | |
Aoyama et al. (2014) | 2014 | Japan | Zingiber officinale ROSCOE | |
Ahmed (2013) | 2013 | Iraq | Olea europaea L. | |
Ahmed et al. (2013) | 2013 | Iraq | Olea europaea L. | |
Ghalayani et al. (2013) | 2013 | Iran | Punica granatum L. | |
Abdollahzadeh et al. (2011) | 2011 | Iran | Punica granatum L. | |
Das et al. (2011) | 2011 | India | Glycyrrhiza glabra L. | |
Babaee et al. (2010) | 2010 | Iran | Myrtus communis L. | |
Kono et al. (2010) | 2010 | Japan | Zingiber officinale ROSCOE | |
Puataweepong et al. (2009) | 2010 | Thailand | Aloe vera L. | |
Shabanloei et al. (2009) | 2009 | Iran | Matricaria recutita L. | |
Martin et al. (2008) | 2008 | USA | Glycyrrhiza glabra L. | |
Tiemann et al. (2007) | 2007 | Europe | Matricaria recutita L. Commiphora myrrha (NEES) ENGL Krameria lappacea (DOMBEY) BURDET & B.B. SIMPSON | |
(Hubbert et al. (2006) | 2006 | Europe | Salvia officinalis L. | |
(Shrivastava and John (2006) | 2006 | Europe | Alchemilla vulgaris L. | |
(Su et al. (2004) | 2004 | USA | Aloe vera L. | |
(Fidler et al. (1996) | 1996 | USA | Matricaria recutita L |
References | |
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Achmüller, Arnold. 2012. Teufelskraut, Bauchwehblüml, Wurmtod: das Kräuterwissen Südtirols : Mythologie, Volksmedizin und wissenschaftliche Erkenntnisse. Bozen: Edition Raetia | PS |
Adler, Martin. 2010. Lehrbuch Naturheilverfahren: 106 Tabellen. Stuttgart: Georg Thieme Verlag | SL |
Hensel, Wolfgang. 2014. Welche Heilpflanze ist das? : [über 350 Heilpflanzenarten aus ganz Europa kennenlernen und sicher bestimmen]. Stuttgart: Kosmos | PI |
Jänicke, Christof, Jörg Grünwald, and Thomas Brendler. 2003. Handbuch Phytotherapie: Indikationen, Anwendungen, Wirksamkeit, Präparate. Stuttgart: WVG, Wissenschaftliche Verlagsgesellschaft | SL |
Landespflege, Bayerischer Landesverband f Gartenbau u, Eleonore Hohenberger, and Willi Votteler. 2017. Gewürzkräuter und Heilpflanzen. 7th ed. München: Obst- und Gartenbauverlag des Bayerischen Landesverbandes für Gartenbau und Landespflege e.V | PI |
Mayer, Johannes Gottfried, Bernhard Uehleke, and Kilian Saum. 2013. “Das” große Buch der Klosterheilkunde: neues Wissen über die Wirkung der Heilpflanzen ; vorbeugen, behandeln und heilen. Zabert Sandmann | PS |
Niederegger, Oswald, and Christoph Mayr. 2005. Hausbuch der Südtiroler Heilkraeuter Gesundheit aus der Natur. Bozen: Athesia | PS |
Pahlow, Mannfried. 2004. Das große Buch der Heilpflanzen: Gesund durch die Heilkräfte der Natur. Hamburg: Nikol Verlagsges.mbH | PS |
Prentner, Angelika. 2017. Heilpflanzen der Traditionellen Europäischen Medizin: Wirkung und Anwendung nach häufigen Indikationen. Berlin: Springer-Verlag | PI |
Rätsch, Christian. 2014. Heilpflanzen der Antike: Mythologie, Heilkunst und Anwendung. Aarau: AT Verlag | PS |
Schönfelder, Ingrid, and Peter Schönfelder. 2001. Der Kosmos Heilpflanzenführer. Stuttgart: Kosmos | PI |
Seitz, Paul. n.d. Heil- Und Gewürzpflanzen Aus Dem Eigenen Garten. 13. Auflage. Bonn: aid Infodienst Ernähung, Landwirtschaft, Verbraucherschutz | PI |
Steigerwald, Petra-Angela. 2015. Phytotherapie pocket. Grünwald: Boerm Bruckmeier | SL |
Wichtl, Max, and Franz-Christian Czygan. 2002. Teedrogen und Phytopharmaka: ein Handbuch für die Praxis auf wissenschaftlicher Grundlage. Stuttgart: Wissenschaftliche Verlagsgesellschaft | SL |
Latin designation | N (mentioned) | Latin designation | N (mentioned) |
---|---|---|---|
Matricaria recutita L. | 13 | Tilia cordata MILL. et platyphyllos SCOP | 2 |
Salvia officinalis et sclarea L. | 12 | Ulmus minor MILL | 2 |
Althaea officinalis L. | 11 | Violar tricolor L. et Viola arvensis Murray | 2 |
Malva sylvestris L. et Malva neglecta WALLER | 11 | Achillea millefolium L. | 1 |
Calendula officinalis L. | 10 | Ajuga reptans L. | 1 |
Plantago lanceolata L. | 10 | Alnus glutinosa L | 1 |
Potentilla erecta L. | 10 | Aloe barbadensis L. (BURM. F.) | 1 |
Cetraria islandica L. | 9 | Angelica archangelica L. | 1 |
Arnica montana L. | 8 | Anthyllis vulneraria L | 1 |
Polygonum aviculare L. | 8 | Betonicum officinalis L | 1 |
Agrimonia eupatoria L. | 7 | Carum carvi L. | 1 |
Potentilla anserina L. | 7 | Centaurium erythraea RAFN | 1 |
Quercus robur L. | 7 | Fragaria vesca L. | 1 |
Rubus sect. Rubus | 7 | Gentiana lutea L | 1 |
Thymus vulgaris L. | 7 | Geum rivale L. | 1 |
Tussilago farfara L. | 7 | Gnaphalium uliginosum L. | 1 |
Prunus spinosa L. | 6 | Hieracium pilosella L. | 1 |
Vaccinum myrtillus | 6 | Menyanthis trifoliata L. | 1 |
Alchemilla vulgaris L. | 5 | Mespilus germanica L. | 1 |
Commiphora myrrha (NEES) ENGL | 5 | Myrtus communis L. | 1 |
Geum urbanum L. | 5 | Nasturtium officinale R. BR. IN AIT | 1 |
Rubus ideaus L. | 5 | Orchis morio L. | 1 |
Verbena officinalis L. | 5 | Origanum dictamnus L. | 1 |
Chamaemelum nobie L. | 4 | Origanum majorana L. | 1 |
Lamium album L. | 4 | Paeonia officinalis L. | 1 |
Mentha arvensis L. et Mentha × piperita L. | 4 | Polygonum bistorta L. | 1 |
Pimpinella saxifraga L. | 4 | Prunella vulgaris L. | 1 |
Ribes nigrum L. | 4 | Pulmonaria officinalis L. | 1 |
Syzygium aromaticum L. | 4 | Punica granatum L. | 1 |
Juglans regia L. | 3 | Sambucus nigra L. | 1 |
Rosa gallica L. et Rosa centifolia L. | 3 | Sanguisorba officinalis L. | 1 |
Allium cepa L. | 2 | Sanicula europaea L. | 1 |
Geranium robertianum L. | 2 | Sempervivum tectorum L. | 1 |
Glechoma hederacea L. | 2 | Tamarix spp. L. | 1 |
Glycyrrhiza glabra L. | 2 | Teurcrium scorodonia L. | 1 |
Hyssopus officinalis L. | 2 | Trifolium arvense L. | 1 |
Ocimum basilicum L. | 2 | Usnea sp. DILL. ex ADANS | 1 |
Origanum vulgare L. | 2 | Veroninca officinalis L. | 1 |
Rheum palmatum L. | 2 | Zingiber officinale ROSCOE | 1 |
Authors | Year | N (pts) | Trial type (Jadad) | Level of evidence | Plants investigated | Plant compared to | Result |
---|---|---|---|---|---|---|---|
(Cabrera-Jaime et al. 2018) | 2018 | 50 | RCT* (4) | IB | Plantago major L. | Plant vs. control (chlorhexidine/bicarbonate wash) | No difference |
(Charalambous et al. 2017) | 2018 | 72 | RCT (3) | IB | Thymus vulgaris L. | Plant vs. c control (saline wash) | Pos. plant |
(Kato et al. 2017) | 2017 | 14 | CT (2) | IIIB | Matricaria recutita L., Zingiber officinalis ROSCOE (Hangeshashinto) | Plant | – |
(Marucci et al. 2017) | 2017 | 104 | PCT* (5) | IB | Matricaria recutita L., Calendula officinalis L., Aloe vera L., | Plant vs. placebo | No difference |
(Azad et al. 2016) | 2016 | 46 | RCT (3) | IB | Cymbopogon flexuosus NEES EX STEUD., Thymus zygis L., Rosmarinus officinalis L | Plant vs. control (standard care) | Pos. plant |
(Bardellini et al. 2016) | 2016 | 87 | RCT (3) | IB | Matricaria recutita L., Calendula officinalis L., Aloe vera L | Plant vs. control (hyaluronic acid) | Pos. plant |
(Dos Reis et al. 2016) | 2016 | 38 | RCT (3) | IB | Matricaria recutita L. | Plant vs. control (ice cube) | No difference |
(Goes et al. 2016) | 2016 | 30 | PCT* (5) | IB | Matricaria recutita L. | Plant vs. placebo | Pos. Plant |
(Mutluay Yayla et al. 2016) | 2016 | 60 | RCT (3) | IB | Salvia officinalis L., Mentha × piperita L., Thymus vulgaris L. | Plant vs. basal oral care | Pos. plant |
(Andishe Tadbir et al. 2015) | 2015 | 43 | PCT* (5) | IB | Matricaria recutita L. | Plant vs. placebo | Pos. plant |
(Mahyari et al. 2016) | 2015 | 60 | PCT* (5) | IB | Zingiber officinalis ROSCOE, Rosmarinus officinalis L., Thymus vulgaris L. | Plant vs. placebo | Pos. plant |
(Tavakoli Ardakani et al. 2016) | 2015 | 60 | PCT* (5) | IB | Matricaria recutita L., Mentha × piperita L. | Plants vs. placebo | Pos. plant |
(Widén et al. 2015) | 2015 | 32 | PCT (4) | IIB | Vaccinium myrtillus L. | Plant vs. placebo (starch) | Pos. plant |
(Braga et al. 2015) | 2014 | 40 | RCT (3) | IB | Matricaria recutita L. | Plant different concentrations vs. control (standard care) | Pos. plant |
(Seyyedi et al. 2014) | 2014 | 36 | PCT* (5) | IB | Matricaria recutita L. | Plant vs placebo | Pos. plant |
(Steinmann et al. 2012) | 2012 | 20 | CT (2) | IIB | Salvia officinalis L | Plant vs. Traumeel S ® | No difference |
(George et al. 2009) | 2009 | 30 | RCT* (4) | IIB | Matricaria recutita L., Salvia officinalis L., Commiphora myrrha NEES ENGL., Eucalyptus L ‘HER | Plant vs. control (conventional dentifrice) | Pos. plant |
(Schapowal et al. 2009) | 2009 | 133 | RCT* (4) | IB | Salvia officinalis L., Ecchinacea L. | Plant vs. control (chlorhexidine/ lidocaine) | No difference |
(Shabanloei et al. 2009) | 2009 | 83 | PCT* (5) | IB | Matricaria recutita L. | Plant vs. placebo | Pos. plant |
(Hubbert et al. 2006) | 2006 | 286 | PCT* (5) | IB | Salvia officinalis L. | Plant (different concentrations) vs. placebo | Pos. plant |
(Tiemann et al. 2007) | 2006 | 32 | CT (2) | IIB | Matricaria recutita L., Commiphora myrrha NEES ENGL., Krameria lappacea (DOMBEY) BURDET & B. B. SIMPSON | Plant, baseline vs. termination time point | – |
(González Begné et al. 2001) | 2001 | 60 | CT (2) | IIB | Polygonum aviculare L. | Plant (baseline vs. improvement over time) | Pos. plant |
(Saller et al. 2001) | 2001 | 145 | RCT* (4) | IB | Salvia officinalis L., Rheum L | Plant/plant combination vs. control (acyclovir) | No difference |
(Fidler et al. 1996) | 1996 | 164 | PCT* (5) | IB | Matricaria recutita L | Plant vs. placebo | No difference |
Qualitative analysis
Assessment of the effect of medical plants on symptoms of oral mucositis
Score (based on the p value) | Interpretation |
---|---|
0 | No difference |
1 | Positive for plant (p < 0.05) |
2 | Strongly positive for plant (p < 0.01) |
Figures and illustrations
Results
Few studies investigate medical plants recommended for treating oral mucositis by TEM
Search results and characteristics of included studies
Results of semi-quantitative analysis on the overall impact of medical plants on treating oral mucositis
Results of semi-quantitative analysis of the impact of medical plants on treating oral mucositis and stomatitis
Results of semi-quantitative analysis on the impact of medical plants on treating pharyngitis
Results of semi-quantitative analysis on the impact of medical plants on treating gingivitis and periodontitis
Results of sub-group analyses for the evidence of single plants for treating oral mucositis
Matricaria recutita L. | Salvia officinalis L. | Calendula officinallis L. | Thymus spp. L | ||||
---|---|---|---|---|---|---|---|
Studies investigating herbs for treating oral mucositis (scored) | |||||||
Bardellini* | 2016 | Mutluay Yayla* | 2016 | Marucci* | 2017 | Charalambous | 2018 |
Dos Reis | 2016 | Steinmann | 2012 | Bardellini* | 2016 | Azad* | 2016 |
Goes | 2016 | George* | 2009 | Mahyari* | 2015 | Yayla* | 2016 |
Tavakoli Ardakani* | 2015 | Schapowal* | 2009 | ||||
Marucci* | 2015 | Hubbert | 2006 | ||||
Anidshe Tadbir | 2015 | Saller* | 2002 | ||||
Braga | 2014 | ||||||
Seyyedi | 2014 | ||||||
George* | 2009 | ||||||
Shabanloei | 2009 | ||||||
Fidler | 1996 |
Aloe vera L. | Mentha × piperita L. | Rosmarinus officinalis L. | Cymbopogon flexuosus SPRENG | ||||
---|---|---|---|---|---|---|---|
Further studies of medical plants (not scored) | |||||||
Marucci* | 2017 | Yayla* | 2016 | Azad* | 2016 | Azad* | 2016 |
Bardellini* | 2016 | Ardakani* | 2015 | Mahyari* | 2015 |
Ecchinacea L. | Eucalyptus L’HER | Commiphora myrrha (NEES) ENGL | Plantago major L. | ||||
---|---|---|---|---|---|---|---|
Further studies of medical plants (not scored) | |||||||
Schapowal* | 2009 | George* | 2009 | George* | 2009 | Cabrera-Jaime | 2018 |
Polygonum aviculare L. | Rheum L. | Vaccinum myrtillius L. | Zingiber officinalis ROSCOE | ||||
---|---|---|---|---|---|---|---|
Further studies of medical plants (not scored) | |||||||
González Begné | 2001 | Saller* | 2002 | Widén | 2015 | Mahyari* | 2015 |