Wolff-Parkinson-White syndrome (WPWS) is a disease, described for the first time in 1930, characterized by a short PR interval associated with ventricular preexcitation manifested by a delta wave. This disease can generate symptomatic or asymptomatic arrhythmias and, in the most unfortunate cases, sudden death. Cardiac electrical activity starts in the sinus node, physiologically, located in the right atrium, propagates through the atrioventricular node and through the bundle of His into the ventricles. The atrioventricular node functions as a gate, limiting the electrical activity that reaches the ventricles. Patients with WPWS have an accessory pathway that connects the atria and ventricles, in addition to the atrioventricular node. This accessory pathway is the bundle of Kent. This accessory bundle can conduct electrical impulses much faster than atrioventricular node. This event itself is unfavorable: heart rates as fast as they occur in this disease, may develop hemodynamic problems and cardiovascular shock [
1‐
3]. The diagnosis is made by electrocardiogram (ECG) in subjects without symptoms. Typical signs of the disease are: supraventricular tachycardia (38 percent), palpitations (22 percent), chest pain (5 percent), syncope (4 percent), atrial fibrillation (0.4 percent), sudden death (0.2 percent), and incidental findings (26 percent); data were unavailable in 4 percent. Subjects can also develop lightheadedness and/or dizziness [
4,
5]. The treatments of the pathology are drug therapy, radiofrequency ablation, and surgical ablation. The patients who suffer from atrial fibrillation and rapid ventricular response are treated with amiodarone or procainamide to monitor always their heart rate [
6]. AV node blockers should be avoided in atrial fibrillation and atrial flutter with WPW or history of it; this includes adenosine, diltiazem, verapamil, other calcium channel blockers and beta-blockers may aggravate the syndrome by blocking the normal electrical pathway of the heart. The definitive treatment of WPW is a destruction of the abnormal electrical pathway catheter ablation radiofrequence [
7]. It is very important to maintain the best oral health in these patients. There is no documented evidence in the literature. Patients with this type of pathology must be kept under control and must undergo specialized controls consistently. In addition, these patients should be able to maintain a good level of oral health. Dental procedures must be kept under antibiotic cover only when it is necessary and the use of equipment that bestow pulses of electrical stimulation (transcutaneous electrical nervous stimulation (TENS), radiofrequency scalpel, piezosurgery) is banned because it may interfere with heart rhythm [
8]. Regarding procedures, such as dental calculus removal, pursued by mechanical equipment, clinicians are encouraged to ask for specialist advice from the cardiologist. The aim of this manuscript is to show how to behave in the case of WPWS in a child, in order to adopt best practices without interfering with the pathology.