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01.12.2012 | Research | Ausgabe 1/2012 Open Access

World Journal of Surgical Oncology 1/2012

HtrA1 expression associated with the occurrence and development of esophageal cancer

Zeitschrift:
World Journal of Surgical Oncology > Ausgabe 1/2012
Autoren:
Youtao Yu, Wenlong Shao, Yi Hu, Jingyan Zhang, Hao Song, Zhi-hua Zhu
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1477-7819-10-179) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare no competing interest.

Authors’ contributions

YY: Design, acquisition of data, analysis and interpretation of data, drafting of manuscript, critical revision, final approval. WS: Design, drafting of manuscript, critical revision, final approval. YH: Design, acquisition of data, critical revision, final approval. JZ: Design, acquisition of data, critical revision, final approval. HS: Design, acquisition of data, analysis and interpretation of data, drafting of manuscript, critical revision, final approval. ZZ: Design, acquisition of data, analysis and interpretation of data, drafting of manuscript, critical revision, final approval. All authors read and approved the final manuscript.

Abstract

Background

The purposes of this study were to measure both the mRNA and protein expression levels of high-temperature requirement serine peptidase 1 (HtrA1) in human esophageal cancer tissues and their adjacent, comparatively normal esophageal tissues.

Methods

The expression levels of HtrA1 mRNA and protein in both tissue types were measured by semi-quantitative RT-PCR (reverse transcription-polymerase chain reaction) and Western blotting. The clinical and pathological correlation between HtrA1 expression levels and the occurrence and development of esophageal cancer was analyzed.

Results

The expression levels of HtrA1 mRNA and protein in esophageal carcinoma were significantly lower than the levels expressed in their adjacent normal esophageal tissue (p < 0.05). The more highly undifferentiated esophageal tumor cells expressed lower HtrA1 mRNA and protein expression levels (p < 0.05). Patients with tumors in early pathological stages (I-II) had significantly higher HtrA1 mRNA and protein expression levels than did patients with tumors in mid-to-late pathological stages (III-IV) (p < 0.05). Patients with positive lymph node metastasis had significantly lower HtrA1 mRNA and protein expression levels than did patients with lymph node-negative disease (p < 0.05).

Conclusions

HtrA1 expression is associated with the occurrence and development of esophageal cancer.
Zusatzmaterial
Authors’ original file for figure 1
12957_2012_1132_MOESM1_ESM.tiff
Authors’ original file for figure 2
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Authors’ original file for figure 3
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Authors’ original file for figure 4
12957_2012_1132_MOESM4_ESM.tiff
Literatur
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