Background
Methods
Compliance
Subjects
Safety assessments
Radiotracer production
Radiotracer administration
Image acquisition protocol
Blood sampling and processing
Radiometabolite analysis
Image analysis and dosimetry calculations
Results
Participant characteristics and radiotracer injection
Participant | Sex | Age range (years) | Race/ethnicity | Weight kg (lb) | Height cm (in) | BMI |
---|---|---|---|---|---|---|
P1 | Female | 40–45 | Caucasian | 79.4 (175) | 155 (61) | 33 |
P2 | Male | 40–45 | More than one race | 73.5 (162) | 175 (69) | 24 |
P3 | Male | 55–60 | Caucasian | 61.2 (135) | 170 (67) | 21.2 |
P4 | Female | 20–25 | Caucasian | 61.2 (135) | 163 (64) | 23 |
Participant | Injected activity MBq (mCi) | Injected mass (microgram) | Effective dose mSv |
---|---|---|---|
P1 | 378.14 (10.22) | 0.216 | 4.20 |
P2 | 381.84 (10.32) | 0.092 | 4.89 |
P3 | 342.25 (9.25) | 0.201 | 3.29 |
P4 | 380.73 (10.29) | 0.091 | 5.60 |
Biodistribution and dosimetry
Target organ | Residence time (h) | Organ dose (μGy/MBq) | Contribution to ED (μSv/MBq) |
---|---|---|---|
Adrenals | 0.0007 ± 0.0002 | 14.6 ± 3.6 | 0.073 ± 0.018 |
Brain | 0.031 ± 0.004 | 6.7 ± 0.6 | 0.034 ± 0.003 |
Breasts | 0.004 ± 0.002 | 4.4 ± 1.1 | 0.221 ± 0.055 |
Gallbladder | 0.0008 ± 0.0004 | 8.3 ± 1.0 | 0 |
Lower large intestine | 0.0058 ± 0.0007 | 8.9 ± 1.6 | 1.064 ± 0.196 |
Small intestine | 0.017 ± 0.011 | 8.3 ± 2.9 | 0.042 ± 0.015 |
Stomach | 0.024 ± 0.009 | 14.6 ± 3.6 | 1.750 ± 0.429 |
Upper large intestine | 0.0052 ± 0.0017 | 7.2 ± 1.8 | 0.036 ± 0.009 |
Heart | 0.0106 ± 0.0015 | 54.6 ± 4.0 | 0 |
Kidneys | 0.039 ± 0.014 | 28.6 ± 9.3 | 0.143 ± 0.046 |
Liver | 0.106 ± 0.018 | 18.4 ± 1.7 | 0.922 ± 0.086 |
Lungs | 0.015 ± 0.003 | 8.4 ± 0.2 | 1.003 ± 0.027 |
Muscle | 0.52 ± 0.30 | 7.0 ± 2.3 | 0.035 ± 0.012 |
Ovaries | 0.0007 ± 0.0005 | 14.9 ± 4.5 | 2.965 ± 0.898 |
Pancreas | 0.0044 ± 0.0006 | 15.5 ± 2.3 | 0.077 ± 0.011 |
Red marrow | 0.052 ± 0.020 | 8.6 ± 2.1 | 1.034 ± 0.248 |
Trabecular bone | 0.015 ± 0.004 | 13.2 ± 1.6 | 0.132 ± 0.016 |
Cortical bone | 0.086 ± 0.024 | 2.6 ± 0.6 | 0.026 ± 0.006 |
Spleen | 0.009 ± 0.002 | 15.0 ± 3.4 | 0.075 ± 0.017 |
Testes | 0.0015 ± 0.004 | 9.8 ± 2.2 | 1.950 ± 0.438 |
Thymus | 0.0006 ± 0.0001 | 11.7 ± 1.6 | 0.059 ± 0.008 |
Thyroid | 0.0003 ± 0.0003 | 5.4 ± 2.2 | 0.271 ± 0.110 |
Urinary bladder | 0.0833 ± 0.0426 | 51.4 ± 30.3 | 2.568 ± 1.512 |
Uterus | 0.0015 ± 0.0015 | 9.4 ± 6.9 | 0.047 ± 0.034 |
Total effective dose | 12.1 ± 2.2 μSv/MBq |