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03.05.2019 | Original Article

Human endogenous retrovirus, HERV-P and HERV-R in pediatric leukemia patients

verfasst von: Massimiliano Bergallo, Katia Mareschi, Paola Montanari, Cristina Calvi, Massimo Berger, Ilaria Bini, Valentina Daprà, Ilaria Galliano, Franca Fagioli

Erschienen in: Journal of Hematopathology | Ausgabe 2/2019

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Abstract

The “HERVs” (human endogenous retroviruses) are a family of endogenous retroviruses integrated into the germ cell DNA of primate over than 30 million years ago. HERV expression seems impaired in several diseases, ranging from autoimmune to neoplastic disorders. The purpose of this study was to evaluate the overall endogenous retroviral transcription profile in bone marrow (BM) samples. A total of 30 pediatric lymphoid and myeloid malignancies patients were tested. Our findings show that HERV-R expression results significantly higher in leukemia patients than donors. This overexpression might be related to lymphatic leukemogenesis and it warrants further investigations.

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Titel: Human endogenous retrovirus, HERV-P and HERV-R in pediatric leukemia patients
verfasst von: Massimiliano Bergallo
Katia Mareschi
Paola Montanari
Cristina Calvi
Massimo Berger
Ilaria Bini
Valentina Daprà
Ilaria Galliano
Franca Fagioli
Publikationsdatum: 03.05.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Hematopathology / Ausgabe 2/2019
Print ISSN: 1868-9256
Elektronische ISSN: 1865-5785
DOI: https://doi.org/10.1007/s12308-019-00352-0

Neu im Fachgebiet Pathologie

01.04.2024 | Forensische Traumatologie | CME

Springer Medizin

Human endogenous retrovirus, HERV-P and HERV-R in pediatric leukemia patients

Abstract

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Theoretische Grundlagen von Explosionen und Explosionsverletzungen

Auswirkungen vorgeschalteter Laborprozesse auf die Digitalisierung histologischer Schnittpräparate

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Herausforderungen der Automation bei der quantitativen Auswertung von Leberbiopsien

Springer Medizin

Abstract

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