Erschienen in:
01.12.2008 | Letter to the Editor
Human leukocyte antigen-DR negative de novo acute myeloid leukemia with Philadelphia chromosome
verfasst von:
Tohru Inaba, Hiroshi Nishimura, Junko Saito, Yoko Yamane, Takuya Nakatani, Mio Yamamoto, Hitoji Uchiyama, Naohisa Fujita
Erschienen in:
International Journal of Hematology
|
Ausgabe 5/2008
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Excerpt
It is well known that human leukocyte antigen (HLA)-DR is present in the majority of acute myeloid leukemia (AML) [
1,
2]. However, acute promyelocytic leukemia (APL) with t(15;17)(q22;q12) usually lacks the HLA-DR expression as well as CD34 expression [
2,
3]. Recently, such HLA-DR
−/CD34
− phenotype has also been described in a subset of AML with cuplike nuclear invaginations (AML-cuplike) [
4]. Cytogenetically or molecular genetically, AML-cuplike is characterized with normal karyotype and high frequency of FMS-like tyrosine kinase 3 (
FLT3) gene internal tandem duplication (ITD) as well as nucleophosmin (
NPM1) gene mutation [
4,
5]. In this paper, we reported an extremely rare case of HLA-DR
−/CD34
− AML, which was not categorized into either APL or AML-cuplike and showed Philadelphia chromosome (Ph) at diagnosis. …