nach oben

Journal of Cancer Research and Clinical Oncology

Erschienen in:

24.06.2019 | Review – Cancer Research

Human papillomavirus and lung cancer: an overview and a meta-analysis

verfasst von: M. M. Tsyganov, A. M. Pevzner, M. K. Ibragimova, I. V. Deryusheva, N. V. Litviakov

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 8/2019

Einloggen, um Zugang zu erhalten

Abstract

Purpose

This review is devoted to assessing the prevalence of human papillomavirus (HPV) in lung cancer (LC) in the world. HPV is recognized as the etiological factor of cervical cancer, however, there is widespread evidence that this virus is detected not only in gynecological carcinomas, but also in tumors of other organs, in particular the upper respiratory tract and digestive tract.

Materials and methods

A search was conducted to a depth of 29 years in the PubMed, Web of Science, Scopus, databases. The review includes 95 articles.

Results

Of all the analyzed studies (9195 patients), 12 works showed a complete absence of HPV in the biological material in patients with LC. The absence of a virus among lung cancer patients has been established for Canada, the Netherlands and Singapore. The highest average percent of occurrence of this virus is shown for such countries as: Brazil, Korea, Greece and Taiwan (more than 40%). But the highest percentage of HPV occurrence by region is observed in Latin America (33.5%), followed by the Asian countries (31%), in European countries the frequency is 18%. Interestingly, the highest occurrence of high oncogenic types (16 and 18) is observed in Asia (40.3%), then in Latin America (33.6%), Europe (25.6%) and North America (15.4%). Low-oncogenic types (6 and 11) are also predominantly observed in Asia (39.9%), while in Europe and North America 30% and 12.8%, respectively. A meta-analysis of the prevalence of HPV was conducted using Comprehensive Meta-Analysis 3.0. Program, which included 26 studies, the results of which revealed: the prevalence of HPV infection in tumor lung tissue was compared with normal lung tissue OR (95% CI) = 5.38 (3.21–9.00) p < 0.0001, significance was also found for Chinese studies OR = 6.3, 95% CI 3.42–11.53, p < 0.0001, I2 = 71.8% and for nine studies in Europe OR = 6.3, 95% CI 1.8–22.18, p = 0.004, I2 = 51.0%. However, given the fact that the frequency of occurrence of HPV in lung tumor tissue varies greatly, a question may arise about the real role of HPV in LC carcinogenesis, which makes further research relevant and promising.

Aguayo F et al (2007) Human papillomavirus-16 is integrated in lung carcinomas: a study in Chile. Br J Cancer 97:85CrossRefPubMedPubMedCentral

Aguayo F et al (2011) Human papillomavirus and Epstein–Barr virus infections in breast cancer from chile. Infect Agent Cancer 6:7CrossRefPubMedPubMedCentral

Al-Ghamdi A, Sanders C, Keefe M, Coggon D, Maitland N (1995) Human papillomavirus DNA and TP53 mutations in lung cancers from butchers. Br J Cancer 72:293CrossRefPubMedPubMedCentral

Anantharaman D et al (2014) No causal association identified for human papillomavirus infections in lung cancer. Cancer Res 74:3525–3534CrossRefPubMed

Baba M et al (2010) Human papillomavirus is frequently detected in gefitinib-responsive lung adenocarcinomas. Oncol Rep 23:1085–1092PubMed

Bejui-Thivolet F, Chardonnet Y, Patricot L (1990) Human papillomavirus type 11DNA in papillary squamous cell lung carcinoma. Virchows Archiv A 417:457–461CrossRef

Bernard H-U, Burk RD, Chen Z, van Doorslaer K, zur Hausen H, de Villiers E-M (2010) Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments. Virology 401:70–79CrossRefPubMed

Bohlmeyer T, Le TN, Shroyer AL, Markham N, Shroyer KR (1998) Detection of human papillomavirus in squamous cell carcinomas of the lung by polymerase chain reaction. Am J Respir Cell Mol Biol 18:265–269CrossRefPubMed

Brouchet L, Valmary S, Dahan M, Didier A, Galateau-Salle F, Brousset P, Degano B (2005) Detection of oncogenic virus genomes and gene products in lung carcinoma. Br J Cancer 92:743CrossRefPubMedPubMedCentral

Buyru N, Altinisik J, Isin M, Dalay N (2008) p53 codon 72 polymorphism and HPV status in lung cancer. Med Sci Monit 14(CR493):CR497

Bychkov V, Nikitina E, Ibragimova M, Kaigorodova E, Choinzonov E, Litviakov N (2016) Comprehensive meta-analytical summary on human papillomavirus association with head and neck cancer. Exp Oncol 38:68–72CrossRefPubMed

Carpagnano GE et al (2011) HPV in exhaled breath condensate of lung cancer patients. Br J Cancer 105:1183CrossRefPubMedPubMedCentral

Castillo A et al (2006) Human papillomavirus in lung carcinomas among three Latin American countries. Oncol Rep 15:883–888PubMed

Cheng Y-W et al (2001) The association of human papillomavirus 16/18 infection with lung cancer among nonsmoking. Taiwan Women Cancer Res 61:2799–2803PubMed

Cheng Y-W et al (2004) Gender difference in human papillomavirus infection for non-small cell lung cancer in Taiwan. Lung Cancer 46:165–170CrossRefPubMed

Chiou HL, Wu MF, Liaw YC, Cheng YW, Wong RH, Chen CY, Lee H (2003) The presence of human papillomavirus type 16/18 DNA in blood circulation may act as a risk marker of lung cancer in Taiwan. Cancer Interdiscip Int J Am Cancer Soc 97:1558–1563

Ciotti M et al (2006) Detection and expression of human papillomavirus oncogenes in non-small cell lung cancer. Oncol Rep 16:183–189PubMed

Clavel CE et al (2000) Detection of human papillomavirus DNA in bronchopulmonary carcinomas by hybrid capture II: a study of 185 tumors. Cancer 88:1347–1352CrossRefPubMed

Coissard CJ, Besson G, Polette MC, Monteau M, Birembaut PL, Clavel CE (2005) Prevalence of human papillomaviruses in lung carcinomas: a study of 218 cases. Mod Pathol 18:1606CrossRefPubMed

Colombara DV et al (2015) Prior human polyomavirus and papillomavirus infection and incident lung cancer: a nested case–control study. Cancer Causes Control 26:1835–1844CrossRefPubMedPubMedCentral

Colombara DV et al (2016) Absence of an association of human polyomavirus and papillomavirus infection with lung cancer in China: a nested case–control study. BMC Cancer 16:342CrossRefPubMedPubMedCentral

Da J, Chen L, Hu Y (1996) Human papillomavirus infection and p53 gene mutation in primary lung cancer. Zhonghua zhong liu za zhi Chin J Oncol 18:27–29

Dahlstrom KR et al (2014) Sexual transmission of oral human papillomavirus infection among men. Cancer Epidemiol Prev Biomark 23:2959–2964CrossRef

de Freitas AC, Gurgel AP, de Lima EG, São Marcos BDF, do Amaral CMM (2016) Human papillomavirus and lung carcinogenesis: an overview. J Cancer Res Clin Oncol 142:2415–2427CrossRefPubMed

de Oliveira THA et al (2018) Presence and activity of HPV in primary lung cancer. J Cancer Res Clin Oncol 144:1–10CrossRef

Fakhry C et al (2008) Improved survival of patients with human papillomavirus–positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst 100:261–269CrossRefPubMed

Falcone MG, Cuello M, Garcia A, Recondo G, Avagnina M, Denninghoff V (2017) P1. 02-035 human papillomavirus infection in lung squamous cell carcinoma and correlation to p16 INK4a expression from an Argentine population. J Thorac Oncol 12:S1937–S1938CrossRef

Fan R, Hou W-J, Zhao Y-J, Liu S-L, Qiu X-S, Wang E-H, Wu G-P (2016) Overexpression of HPV16 E6/E7 mediated HIF-1α upregulation of GLUT1 expression in lung cancer cells. Tumor Biol 37:4655–4663CrossRef

Fei Y et al (2006) Different human papillomavirus 16/18 infection in Chinese non-small cell lung cancer patients living in Wuhan, China. Jpn J Clin Oncol 36:274–279CrossRefPubMed

Ferlay J et al (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136:E359–E386CrossRefPubMed

Fong KM, Schonrock J, Frazer IM, Zimmerman PL, Smith PJ (1995) Human papillomavirus not found in squamous and large cell lung carcinomas by polymerase chain reaction. Cancer 75:2400–2401CrossRefPubMed

Galvan A, Noci S, Taverna F, Lombardo C, Franceschi S, Pastorino U, Dragani TA (2012) Testing of human papillomavirus in lung cancer and non-tumor lung tissue. BMC Cancer 12:512CrossRefPubMedPubMedCentral

Gatta LB et al (2012) Human papillomavirus DNA and p16 gene in squamous cell lung carcinoma. Anticancer Res 32:3085–3089PubMed

Giuliani L et al (2007) Detection of oncogenic viruses (SV40, BKV, JCV, HCMV, HPV) and p53 codon 72 polymorphism in lung carcinoma. Lung Cancer 57:273–281CrossRefPubMed

Gorgoulis VG et al (1999) Human papilloma virus (HPV) is possibly involved in laryngeal but not in lung carcinogenesis. Hum Pathol 30:274–283CrossRefPubMed

Goto A et al (2011) Human papillomavirus infection in lung and esophageal cancers: analysis of 485 Asian cases. J Med Virol 83:1383–1390CrossRefPubMed

Guan P, Yin Z, Li X, Wu W, Zhou B (2012) Meta-analysis of human lung cancer microRNA expression profiling studies comparing cancer tissues with normal tissues. J Exp Clin Cancer Res 31:54CrossRefPubMedPubMedCentral

Gupta P, Haldar D, Naru J, Dey P, Aggarwal AN, Minz RW, Aggarwal R (2016) Prevalence of human papillomavirus, Epstein-Barr virus, and cytomegalovirus in fine needle aspirates from lung carcinoma: a case–control study with review of literature. Diagn Cytopathol 44:987–993CrossRefPubMed

Hasegawa Y et al (2014) Human papilloma virus in non-small cell lung cancer in never smokers: a systematic review of the literature. Lung Cancer 83:8–13CrossRefPubMed

Hennig E, Di AL, Venuti A, Holm R, Marcante M, Nesland J (1999a) HPV 16 in multiple neoplastic lesions in women with CIN III. J Exp Clin Cancer Res CR 18:369–377PubMed

Hennig E, Suo Z, Karlsen F, Holm R, Thoresen S, Nesland J (1999b) HPV positive bronchopulmonary carcinomas in women with previous high-grade cervical intraepithelial neoplasia (CIN III). Acta Oncol (Stockh, Swed) 38:639–647CrossRef

Herceg Z, Vaissière T (2011) Epigenetic mechanisms and cancer: an interface between the environment and the genome. Epigenetics 6:804–819CrossRefPubMed

Hirayasu T, Iwamasa T, Kamada Y, Koyanagi Y, Usuda H, Genka K (1996) Human papillomavirus DNA in squamous cell carcinoma of the lung. J Clin Pathol 49:810–817CrossRefPubMedPubMedCentral

Hiroshima K, Toyozaki T, Iyoda A, Ohwada H, Kado S, Shirasawa H, Fujisawa T (1999) Ultrastructural study of intranuclear inclusion bodies of pulmonary adenocarcinoma. Ultrastruct Pathol 23:383–389CrossRefPubMed

Hung RJ et al (2008) A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature 452:633–637CrossRefPubMed

Ibragimova MK et al (2016) Integrative and episomal forms of genotype 16 virus human papilloma during cervical intraepithelial neoplasia and cancer of the matt neck. Probl Virol 61:270–274

Ibragimova M, Tsyganov M, Shpileva O, Churuksaeva O, Bychkov V, Kolomiets L, Litviakov N (2018a) HPV status and its genomic integration affect survival of patients with cervical cancer. Neoplasma 65:441–448CrossRefPubMed

Ibragimova MK, Tsyganov MM, Litviakov NV (2018b) Human papillomavirus and colorectal cancer. Med Oncol 35:140CrossRefPubMed

Ibragimova MK et al (2018c) The clinical observation of human papillomavirus positive breast tumor. Bull Sib Med 17:232–238CrossRef

Iwakawa R, Kohno T, Enari M, Kiyono T, Yokota J (2010) Prevalence of human papillomavirus 16/18/33 infection and p53 mutation in lung adenocarcinoma. Cancer Sci 101:1891–1896CrossRefPubMed

Iwamasa T, Miyagi J, Tsuhako K, Kinjo T, Kamada Y, Hirayasu T, Genka K (2000) Prognostic implication of human papillomavirus infection in squamous cell carcinoma of the lung. Pathol-Res Pract 196:209–218CrossRefPubMed

Jain N et al (2005) Infection of human papillomavirus type 18 and p53 codon 72 polymorphism in lung cancer patients from India. Chest 128:3999–4007CrossRefPubMed

Joh J, Jenson AB, Moore GD, Rezazedeh A, Slone SP, Ghim S-j, Kloecker GH (2010) Human papillomavirus (HPV) and Merkel cell polyomavirus (MCPyV) in non small cell lung cancer. Exp Mol Pathol 89:222–226CrossRefPubMed

Johnson AM et al (2012) Epidemiology of, and behavioural risk factors for, sexually transmitted human papillomavirus infection in men and women in Britain. Sex Transm Infect 88:212–217CrossRefPubMed

Kato T et al (2012) EGFR mutations and human papillomavirus in lung cancer. Lung Cancer 78:144–147CrossRefPubMed

Kaya H, Kotiloglu E, Inanli S, Ekicioglu G, Bozkurt S, Tutkun A, Kullu S (2001) Prevalence of human papillomavirus (HPV) DNA in larynx and lung carcinomas. Pathologica 93:531–534PubMed

Kinoshita I et al (1995) Human papillomavirus type 18 DNA and E6-E7 mRNA are detected in squamous cell carcinoma and adenocarcinoma of the lung. Br J Cancer 71:344CrossRefPubMedPubMedCentral

Klein F, Kotb WFA, Petersen I (2009) Incidence of human papilloma virus in lung cancer. Lung Cancer 65:13–18CrossRefPubMed

Koshiol J et al (2011) Assessment of human papillomavirus in lung tumor tissue. J Natl Cancer Inst 103:501–507CrossRefPubMedPubMedCentral

Kozopas KM, Yang T, Buchan HL, Zhou P, Craig RW (1993) MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc Natl Acad Sci 90:3516–3520CrossRefPubMedPubMedCentral

Krikelis D, Tzimagiorgis G, Georgiou E, Destouni C, Agorastos T, Haitoglou C, Kouidou S (2010) Frequent presence of incomplete HPV16 E7 ORFs in lung carcinomas: memories of viral infection. J Clin Virol 49:169–174CrossRefPubMed

Kulski JK, Demeter T, Mutavdzic S, Sterrett GF, Mitchell KM, Pixley EC (1990) Survey of histologic specimens of human cancer for human papillomavirus types 6/11/16/18 by filter in situ hybridization. Am J Clin Pathol 94:566–570CrossRefPubMed

Langevin SM, Kratzke RA, Kelsey KT (2015) Epigenetics of lung cancer. Transl Res 165:74–90CrossRefPubMed

Li Q, Hu K, Pan X, Cao Z, Yang J, Hu S (1995) Detection of human papillomavirus types 16, 18 DNA related sequences in bronchogenic carcinoma by polymerase chain reaction. Chin Med J 108:610–614PubMed

Lim W-T, Chuah KL, Leong SS, Tan EH, Toh CK (2009) Assessment of human papillomavirus and Epstein-Barr virus in lung adenocarcinoma. Oncol Rep 21:971–975CrossRefPubMed

Lin T-S et al (2005) An association of DNMT3b protein expression with P16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection. Cancer Lett 226:77–84CrossRefPubMed

Liu H, Xing L, Si J (1994) A study of human papillary virus infection by in situ hybridization and histopathology in squamous cell carcinoma of the lung. Zhonghua bing li xue za zhi = Chin J Pathol 23:299–301

Liu F et al (2016a) ERK signaling pathway is involved in HPV-16 E6 but not E7 oncoprotein-induced HIF-1α protein accumulation in NSCLC cells. Oncol Res Featur Preclin Clin Cancer Ther 23:109–118

Liu Y, Lu Z, Xu R, Ke Y (2016b) Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology. Oncotarget 7:5852PubMed

Lu Y, Yu L-Q, Zhu L, Zhao N, Zhou X-J, Lu X (2016) Expression of HIF-1α and P-gp in non-small cell lung cancer and the relationship with HPV infection. Oncol Lett 12:1455–1459CrossRefPubMedPubMedCentral

Mehra R, Egleston B, Yang D, Scott W, Borghaei H, Ragin C (2013) A pilot study of the association and prevalence of the human papillomavirus (HPV) in non-small cell lung cancer (NSCLC). AACR, Washington, DC

Miasko A, Niklińska W, Nikliński J, Chyczewska E, Naumnik W, Chyczewski L (2001) Detection of human papillomavirus in non-small cell lung carcinoma by polymerase chain reaction. Folia Histochem Cytobiol 39:127–128PubMed

Miyagi J, Tsuhako K, Kinjo T, Iwamasa T, Hirayasu T (2000) Recent striking changes in histological differentiation and rate of human papillomavirus infection in squamous cell carcinoma of the lung in Okinawa, a subtropical island in southern Japan. J Clin Pathol 53:676–684CrossRefPubMedPubMedCentral

Miyagi J, Kinjo T, Tsuhako K, Higa M, Iwamasa T, Kamada Y, Hirayasu T (2001) Extremely high Langerhans cell infiltration contributes to the favourable prognosis of HPV-infected squamous cell carcinoma and adenocarcinoma of the lung. Histopathology 38:355–367CrossRefPubMed

Mukeria AF, Zaridze DG (2010) Lung cancer epidemiology and prevention Vestnik RONC im. N. N. Blohina RAMN 21:3–13

Nadji SA et al (2007) Relationship between lung cancer and human papillomavirus in north of Iran, Mazandaran province. Cancer Lett 248:41–46CrossRefPubMed

Niyaz H, Zhao C, Li Y (2000) Detection and significance of HPV16, 18 infection, P53 overexpression and telomerase activity in patients with lung cancer. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chin J Tuberc Respir Dis 23:679–682

Nuorva K, Soini Y, Kamel D, Pöllänen R, Bloigu R, Vähäkangas K, Pääkkö P (1995) p53 protein accumulation and the presence of human papillomavirus dna in bronchiolo-alveolar carcinoma correlate with poor prognosis. Int J Cancer 64:424–429CrossRefPubMed

Ogura H, Watanabe S, Fukushima K, Masuda Y, Fujiwara T, Yabe Y (1993) Human papillomavirus DNA in squamous cell carcinomas of the respiratory and upper digestive tracts. Jpn J Clin Oncol 23:221–225PubMed

Papadopoulou K, Labropoulou V, Davaris P, Mavromara P, Tsimara-Papastamatiou H (1998) Detection of human papillomaviruses in squamous cell carcinomas of the lung. Virchows Arch 433:49–54CrossRefPubMed

Park MS et al (2007) The prevalence of human papillomavirus infection in Korean non-small cell lung cancer patients. Yonsei Med J 48:69–77CrossRefPubMedPubMedCentral

Pillai RN et al (2013) Human papillomavirus (HPV)-associated early stage non-small cell lung cancer (NSCLC). Am Soc Clin Oncol 15:7560–7560

Pira E et al (2005) Cancer mortality in a cohort of asbestos textile workers. Br J Cancer 92:580–586CrossRefPubMedPubMedCentral

Psyrri A, Boutati E, Karageorgopoulou S (2011) Human papillomavirus in head and neck cancers: biology, prognosis, hope of treatment, and vaccines. Anti-cancer Drugs 22:586–590CrossRefPubMed

Ragin C et al (2014) HPV-associated lung cancers: an international pooled analysis. Carcinogenesis 35:1267–1275CrossRefPubMedPubMedCentral

Robinson LA et al (2016) Molecular evidence of viral DNA in non-small cell lung cancer and non-neoplastic lung. Br J Cancer 115:497CrossRefPubMedPubMedCentral

Sagawa M et al (1995) Detection of human papillomavirus type 16, 18 and 33 DNA in stage I (pT1N0M0) squamous cell carcinoma of the lung by polymerase chain reaction Kyobu geka. Jpn J Thorac Surg 48:360–362

Sagerup CM, Nymoen DA, Halvorsen AR, Lund-Iversen M, Helland Å, Brustugun OT (2014) Human papilloma virus detection and typing in 334 lung cancer patients. Acta Oncol 53:952–957CrossRefPubMed

Sarchianaki E et al (2014) Detection and genotype analysis of human papillomavirus in non-small cell lung cancer patients. Tumor Biol 35:3203–3209CrossRef

Shamanin V, Delius H, de Villiers E-M (1994) Development of a broad spectrum PCR assay for papillomaviruses and its application in screening lung cancer biopsies. J Gen Virol 75:1149–1156CrossRefPubMed

Shimizu E et al (1994) RB protein status and clinical correlation from 171 cell lines representing lung cancer, extrapulmonary small cell carcinoma, and mesothelioma. Oncogene 9:2441–2448PubMed

Simen-Kapeu A, Surcel H-M, Koskela P, Pukkala E, Lehtinen M (2010) Lack of association between human papillomavirus type 16 and 18 infections and female lung cancer. Cancer Epidemiol Prev Biomark 19:1879–1881CrossRef

Soini Y, Nuorva K, Kamel D, Pöllänen R, Vähäkangas K, Lehto V-p, Pääkkö P (1996) Presence of human papillomavirus DNA and abnormal p53 protein accumulation in lung carcinoma. Thorax 51:887–893CrossRefPubMedPubMedCentral

Stanley M (2010) Pathology and epidemiology of HPV infection in females. Gynecol Oncol 117:S5–S10CrossRefPubMed

Stremlau A, Gissmann L, Ikenberg H, Stark M, Bannasch P, Hausen HZ (1985) Human papillomavirus type 16 related DNA in an anaplastic carcinoma of the lung. Cancer 55:1737–1740CrossRefPubMed

Syrjänen KJ (1979) Condylomatous changes in neoplastic bronchial epithelium. Respiration 38:299–304CrossRefPubMed

Syrjänen K, Syrjänen S, Kellokoski J, Kärjä J, Mäntyjärvi R (1989) Human papillomavirus (HPV) type 6 and 16 DNA sequences in bronchial squamous cell carcinomas demonstrated by in situ DNA hybridization. Lung 167:33–42CrossRefPubMed

Syrjänen K, Silvoniemi M, Salminen E, Vasankari T, Syrjänen S (2012) Detection of human papillomavirus genotypes in bronchial cancer using sensitive multimetrix assay. Anticancer Res 32:625–631PubMed

Szabó I, Sepp R, Nakamoto K, Maeda M, Sakamoto H, Uda H (1994) Human papillomavirus not found in squamous and large cell lung carcinomas by polymerase chain reaction. Cancer 73:2740–2744CrossRefPubMed

Thomas P, De XL, Garbe L, Douagui H, Kleisbauer J (1995) Detection of human papillomavirus DNA in primary lung carcinoma by nested polymerase chain reaction. Cell Mol Biol (Noisy-le-Grand, Fr) 41:1093–1097

Thomas P, De XL, Garbe L, Castelnau O, Kleisbauer J (1996) Detection of human papillomavirus by polymerase chain reaction in primary lung carcinoma. Bull Cancer 83:842–846PubMed

Toyooka S et al (2011) Molecular oncology of lung cancer. Gen Thorac Cardiovasc Surg 59:527–537CrossRefPubMed

Tsuhako K, Nakazato I, Hirayasu T, Sunakawa H, Iwamasa T (1998) Human papillomavirus DNA in adenosquamous carcinoma of the lung. J Clin Pathol 51:741–749CrossRefPubMedPubMedCentral

van Boerdonk RA et al (2013) High-risk human papillomavirus–positive lung cancer: molecular evidence for a pattern of pulmonary metastasis. J Thorac Oncol 8:711–718CrossRefPubMed

Vosa U, Vooder T, Kolde R, Vilo J, Metspalu A, Annilo T (2013) Meta-analysis of microRNA expression in lung cancer. Int J Cancer 132:2884–2893CrossRefPubMed

Vrabec Branica B, Smojver-Ježek S, Juroš Z, Grgić S, Srpak N, Mitrečić D, Gajović S (2010) Detection of human papillomaviruses type 16, 18 and 33 in bronchial aspirates of lung carcinoma patients by polymerase chain reaction: a study of 84 cases in Croatia. Coll Antropol 34:159–162

Wang J, Cheng Y-W, Wu D-W, Chen J-T, Chen C-Y, Chou M-C, Lee H (2006) Frequent FHIT gene loss of heterozygosity in human papillomavirus-infected non-smoking female lung cancer in Taiwan. Cancer Lett 235:18–25CrossRefPubMed

Wang Y, Wang A, Jiang R, Pan H, Huang B, Lu Y, Wu C (2008) Human papillomavirus type 16 and 18 infection is associated with lung cancer patients from the central part of China. Oncol Rep 20:333–339PubMed

Wang Y-H, Chen D-J, Yi T-N, Liu X-H (2010) The relationship among human papilloma virus infection, survivin, and p53 gene in lung squamous carcinoma tissue. Saudi Med J 31:1331–1336PubMed

Wang JL, Fang CL, Wang M, Yu MC, Bai KJ, Lu PC, Liu HE (2014) Human papillomavirus infections as a marker to predict overall survival in lung adenocarcinoma. Int J Cancer 134:65–71CrossRefPubMed

Welt A, Hummel M, Niedobitek G, Stein H (1997) Human papillomavirus infection is not associated with bronchial carcinoma: evaluation by in situ hybridisation and the polymerase chain reaction. J Pathol J Pathol Soc Gt Br Irel 181:276–280

Wistuba II et al (1998) Comparison of molecular changes in lung cancers in HIV-positive and HIV-indeterminate subjects. Jama 279:1554–1559CrossRefPubMed

Wu MF et al (2005) Frequent p16INK4a promoter hypermethylation in human papillomavirus-infected female lung cancer in Taiwan. Int J Cancer 113:440–445CrossRefPubMed

Wu D, Lee M, Wang J, Chen C, Cheng Y, Lee H (2014) DDX3 loss by p53 inactivation promotes tumor malignancy via the MDM2/Slug/E-cadherin pathway and poor patient outcome in non-small-cell lung cancer. Oncogene 33:1515CrossRefPubMed

Xing L, Liu H, Si J (1993) Detection of human papillomavirus DNA in squamous cell carcinomas of the lung by multiple polymerase chain reaction. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chin J Tuberc Respir Dis 16:275–277 (319)

Xing L, Liu H, Si J (1994) Analysis of the characteristics of human papilloma virus infection in 85 neoplasms of the respiratory system in adult patients. Chin J Oncol 16:424–427

Xiong W et al (2016) Association between human papillomavirus infection and lung cancer. Chin J Oncol 37:1658–1661

Xu Y, Cheng B, Pan H, Wu A, Zhang L (2009) The relationship between the status of human papillomavirus 16/18 infection and the expression of Bcl-2 and Bax in squamous cell carcinomas of the lung. Chin J Lung Cancer 12:849–852

Yanagawa N et al (2013) Human papilloma virus genome is rare in North American non-small cell lung carcinoma patients. Lung Cancer 79:215–220CrossRefPubMed

Yang Y, Dong D, Peng L, Ling J, Xiao Y, Zhuang H (1998) A study on the relationship between HPV infection and the oncogenesis of primary squamous carcinoma of the lung. Zhongguo fei ai za zhi = Chin J Lung Cancer 1:35–36

Yang JJ et al (2013) The role of inherited TPMT and COMT genetic variation in cisplatin-induced ototoxicity in children with cancer. Clin Pharmacol Ther 94:252–259CrossRefPubMed

Yousem SA, Paul Ohori N, Sonmez-Alpan E (1992) Occurrence of human papillomavirus DNA in primary lung neoplasms. Cancer 69:693–697CrossRefPubMed

Yu Y, Yang A, Hu S, Yan H (2009) Correlation of HPV-16/18 infection of human papillomavirus with lung squamous cell carcinomas in Western China. Oncol Rep 21:1627–1632PubMed

Yu Y, Yang A, Hu S, Zhang J, Yan H (2013) Significance of human papillomavirus 16/18 infection in association with p53 mutation in lung carcinomas. Clin Respir J 7:27–33CrossRefPubMed

Yu Y, Liu X, Yang Y, Zhao X, Xue J, Zhang W, Yang A (2015) Effect of FHIT loss and p53 mutation on HPV-infected lung carcinoma development. Oncol Lett 10:392–398CrossRefPubMedPubMedCentral

Zafer E, Ergun MA, Alver G, Sahin FI, Yavuzer S, Ekmekci A (2004) Detection and typing of human papillomavirus in non-small cell lung cancer. Respiration 71:88–90CrossRefPubMed

Zhai K, Ding J, Shi H-Z (2015) HPV and lung cancer risk: a meta-analysis. J Clin Virol 63:84–90CrossRefPubMed

Zhang X, Zhu Y, Li L (1995) Point mutation of p53 and detection of human papillomavirus DNA in bronchogenic carcinoma. Zhonghua Nei Ke Za Zhi 34:673–675PubMed

Zur Hausen H (2002) Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2:342CrossRefPubMed

zur Hausen H (2008) Novel human polyomaviruses—re-emergence of a well known virus family as possible human carcinogens. Int J Cancer 123:247–250CrossRefPubMed

Titel: Human papillomavirus and lung cancer: an overview and a meta-analysis
verfasst von: M. M. Tsyganov
A. M. Pevzner
M. K. Ibragimova
I. V. Deryusheva
N. V. Litviakov
Publikationsdatum: 24.06.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 8/2019
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-019-02960-w

Neu im Fachgebiet Onkologie

18.04.2024 | Wirbelsäulenmetastase | Nachrichten

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Human papillomavirus and lung cancer: an overview and a meta-analysis

Abstract

Purpose

Materials and methods

Results

Neu im Fachgebiet Onkologie

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Adjuvante Brustkrebstherapie: Doppelt hält besser

Manche Gestagene können das Risiko für Meningeome erhöhen

Einladung zum PSA-Screening senkt die Krebssterblichkeit

Update Onkologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Materials and methods

Results

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 8/2019

Ginger extract has anti-leukemia and anti-drug resistant effects on malignant cells

Prognostic impact of PIK3CA protein expression in triple negative breast cancer and its subtypes

Cancer patients and music: (prospective) results from a survey to evaluate potential complementary treatment approaches

Association of glutathione-S-transferase p1 gene promoter methylation and the incidence of prostate cancer: a systematic review and meta-analysis

Effect of age on the effectiveness of the first-line standard of care treatment in patients with metastatic colorectal cancer: systematic review of observational studies

Prognosis of carcinoma in situ according to the presence of papillary bladder tumors after bacillus Calmette–Guérin immunotherapy

Neu im Fachgebiet Onkologie

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Adjuvante Brustkrebstherapie: Doppelt hält besser

Manche Gestagene können das Risiko für Meningeome erhöhen

Einladung zum PSA-Screening senkt die Krebssterblichkeit

Update Onkologie